{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:02:48Z","timestamp":1791921768533,"version":"4.3.4"},"reference-count":63,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T00:00:00Z","timestamp":1463184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Restricted diets and inadequate nutrient intake of children with autism spectrum disorder (ASD) have been reported. This study examined the nutritional statuses of children with ASD and the relationships between their behaviors and nutritional intake. A total of 154 children with ASD (age = 5.21 \u00b1 1.83 years) and 73 typically-developing (TD) children (age = 4.83 \u00b1 0.84 years) from Chongqing, China, were enrolled. The severity of ASD was evaluated using the Childhood Autism Rating Scale (CARS). The serum ferritin, folate, vitamin B12, 25(OH) vitamin D, and vitamin A concentrations in the children with ASD were determined. All participants underwent anthropometric examinations, dietary assessments, and questionnaire assessments about their feeding behaviors, and gastrointestinal symptoms. The ZHA, ZWA, and ZBMIA were found to be significantly lower in the children with ASD compared with those without ASD. In addition, the percentages of children exhibiting severe picky eating and severe resistance to new foods, as well as those with a reported general impression of severe eating problems and constipation, were higher among the children with ASD. These children consumed significantly fewer macronutrients compared with the children without ASD. In addition, the children with ASD had the highest rate of vitamin A deficiency, followed by iron deficiency. After adjusting for sex, the vitamin A concentration was found to be negatively correlated with the CARS score (rs = \u22120.222, p = 0.021). No correlation between the ferritin, folate, vitamin D, or vitamin B12 concentration and the CARS score was found. These results suggest that reduced macronutrient intakes, severe feeding behavior issues, constipation, and vitamin A deficiency are quite common among children with ASD. Further, a low serum vitamin A level may be a risk factor for symptoms of ASD. However, the underlying mechanism should be further studied.<\/jats:p>","DOI":"10.3390\/nu8050294","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T10:20:11Z","timestamp":1463480411000},"page":"294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Correlation between Nutrition and Symptoms: Nutritional Survey of Children with Autism Spectrum Disorder in Chongqing, China"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1645-2701","authenticated-orcid":false,"given":"Xiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Child Health Care, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Children\u2019s Nutrition Research Center, Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Children\u2019s Nutrition Research Center, Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Pediatric Department of Clinical Medicine of Dazhou Vocational and Technical College, Dazhou 635001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"Children\u2019s Nutrition Research Center, Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nali","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Children\u2019s Nutrition Research Center, Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Liang","sequence":"additional","affiliation":[{"name":"Children\u2019s Nutrition Research Center, Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Children\u2019s Nutrition Research Center, Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Children\u2019s Nutrition Research Center, Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Children\u2019s 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Acad. Nutr. Diet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.rasd.2011.06.014","article-title":"Dietary patterns and body mass index in children with autism and typically developing children","volume":"6","author":"Evans","year":"2012","journal-title":"Res. Autism Spectr. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1007\/s10803-015-2490-x","article-title":"Food selectivity, mealtime behavior problems, spousal stress, and family food choices in children with and without autism spectrum disorder","volume":"45","author":"Curtin","year":"2015","journal-title":"J. Autism Dev. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/B:JADD.0000037419.78531.86","article-title":"A comparison of eating behaviors between children with and without autism","volume":"34","author":"Schreck","year":"2004","journal-title":"J. Autism Dev. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.biopsych.2007.04.019","article-title":"Olfaction and taste processing in autism","volume":"62","author":"Bennetto","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/1362361303007002004","article-title":"Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders","volume":"7","author":"Molloy","year":"2003","journal-title":"Autism"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1542\/peds.2008-2933","article-title":"Incidence of gastrointestinal symptoms in children with autism: A population-based study","volume":"124","author":"Ibrahim","year":"2009","journal-title":"Pediatrics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/1362361313485164","article-title":"The association between emotional and behavioral problems and gastrointestinal symptoms among children with high-functioning autism","volume":"18","author":"Mazefsky","year":"2014","journal-title":"Autism"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1542\/peds.2012-0900M","article-title":"Iron status in children with autism spectrum disorder","volume":"130","author":"Reynolds","year":"2012","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s10803-008-0606-2","article-title":"Does nutritional intake differ between children with autism spectrum disorders and children with typical development?","volume":"39","author":"Herndon","year":"2009","journal-title":"J. Autism Dev. Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10803-011-1268-z","article-title":"Food variety as a predictor of nutritional status among children with autism","volume":"42","author":"Zimmer","year":"2012","journal-title":"J. Autism Dev. Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00431-010-1203-x","article-title":"A preliminary study on nutritional status and intake in Chinese children with autism","volume":"169","author":"Xia","year":"2010","journal-title":"Eur. J. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/13668250601006924","article-title":"Dietary status and impact of risperidone on nutritional balance in children withautism: A pilot study","volume":"31","author":"Lindsay","year":"2006","journal-title":"J. Intellect. Dev. Disabil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.nut.2012.09.014","article-title":"Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism","volume":"29","author":"Waly","year":"2013","journal-title":"Nutrition"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2431-10-11","article-title":"The prevalence of obesity in children with autism: A secondary data analysis using nationally representative data from the National survey of children\u2019s health","volume":"10","author":"Curtin","year":"2010","journal-title":"BMC Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/chi.2012.0028","article-title":"Obesity in young children with autism spectrum disorders: Prevalence and associated factors","volume":"9","author":"Egan","year":"2013","journal-title":"Child. Obes."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1089\/acm.2009.0349","article-title":"Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism","volume":"16","author":"Meguid","year":"2010","journal-title":"J. Altern. Complement. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/NMD.0b013e3182a2168a","article-title":"Diagnostic and statistical manual of mental disorders, 5th edition, and clinical utility","volume":"201","author":"First","year":"2013","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF01046324","article-title":"Comparison of DSM-III-R and childhood autism rating scale diagnoses of autism","volume":"22","author":"Marcus","year":"1992","journal-title":"J. Autism Dev. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/WNR.0000000000000251","article-title":"Serum copper and zinc levels in individuals with autism spectrum disorders","volume":"25","author":"Li","year":"2014","journal-title":"Neuroreport"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijdevneu.2014.11.007","article-title":"Thioredoxin: A novel, independent diagnosis marker in children with autism","volume":"40","author":"Zhang","year":"2015","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijdevneu.2015.02.002","article-title":"High plasma neopterin levels in Chinese children with autism spectrum disorders","volume":"41","author":"Zhao","year":"2015","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/WNR.0000000000000350","article-title":"Decreased plasma Levels of lipoxin A4 in children with autism spectrum disorders","volume":"26","author":"Yan","year":"2015","journal-title":"Neuroreport"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1177\/15648265040251S105","article-title":"Measurement and standardization protocols for anthropometry used in the construction of a new international growth reference","volume":"25","author":"Onyango","year":"2004","journal-title":"Food Nutr. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/dbp.0b013e31802d410b","article-title":"\u201cCare for Development\u201d intervention in rural China: A prospective follow-up study","volume":"28","author":"Jin","year":"2007","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1651-2227.2005.tb01999.x","article-title":"Outcome of low birthweight in China: A 16-year longitudinal study","volume":"94","author":"Peng","year":"2005","journal-title":"Acta Paediatr."},{"key":"ref_27","unstructured":"Society, CN. (2001). Chinese Dietary Reference Intakes, DRIs, Chinese light industry press."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0003-2697(85)90321-5","article-title":"An isocratic high-performance liquid chromatography method for the simultaneous analysis of plasma retinol, alpha-tocopherol, and various carotenoids","volume":"145","author":"Miller","year":"1985","journal-title":"Anal. Biochem."},{"key":"ref_29","unstructured":"World Health Organization (1997). Iron Deficiency: Indicators for Assessment and Strategies for Prevention, World Health Organization."},{"key":"ref_30","unstructured":"World Health Organization (1996). Indicators for Assessing Vitamin A Deficiency and Their Application in Monitoring and Evaluating Intervention Programmes, World Health Organization."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10803-014-2205-8","article-title":"Nutritional status of children with autism spectrum disorders (ASDs): A case-control study","volume":"45","year":"2015","journal-title":"J. Autism Dev. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1542\/peds.2012-0900L","article-title":"Nutrient intake from food in children with autism","volume":"130","author":"Hyman","year":"2012","journal-title":"Pediatrics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1017\/jns.2013.9","article-title":"Nutritional status survey of children with autism and typically developing children aged 4\u20136 years in Heilongjiang Province, China","volume":"2","author":"Sun","year":"2013","journal-title":"J. Nutr. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.acap.2015.03.008","article-title":"Overweight and obesity in a sample of children with autism spectrum disorder","volume":"15","author":"Shui","year":"2015","journal-title":"Acad. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/DBP.0000000000000198","article-title":"Prevalence and health correlates of overweight and obesity in children with autism spectrum disorder","volume":"36","author":"Borner","year":"2015","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1007\/s10803-008-0583-5","article-title":"Feeding and eating behaviors in children with autism and typically developing children","volume":"38","author":"Martins","year":"2008","journal-title":"J. Autism Dev. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/01942631003757669","article-title":"Mealtime behaviors of preschool children: comparison of children with autism spectrum disorder and children with typical development","volume":"30","author":"Provost","year":"2010","journal-title":"Phys. Occup. Ther. Pediatr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jada.2009.10.032","article-title":"Food selectivity and sensory sensitivity in children with autism spectrum disorders","volume":"110","author":"Cermak","year":"2010","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jpeds.2010.02.013","article-title":"Food selectivity in children with autism Spectrum disorders and typically developing children","volume":"157","author":"Bandini","year":"2010","journal-title":"J. Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jada.2008.05.003","article-title":"Dietary intake and parents\u2019 perception of mealtime behaviors in preschool-Age children with autism spectrum disorder and in typically developing children","volume":"108","author":"Lockner","year":"2008","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1016\/j.ridd.2013.07.026","article-title":"Food selectivity in children with and without an autism spectrum disorder: Investigation of diagnosis and age","volume":"34","author":"Beighley","year":"2013","journal-title":"Res. Dev. Disabil."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.appet.2015.05.016","article-title":"Clinical differences in children with autism spectrum disorder with and without food selectivity","volume":"92","author":"Postorino","year":"2015","journal-title":"Appetite"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ridd.2005.03.005","article-title":"Food preferences and factors influencing food selectivity for children with autism spectrum disorders","volume":"27","author":"Schreck","year":"2006","journal-title":"Res. Dev. Disabil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.biopsych.2006.07.013","article-title":"Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders","volume":"61","author":"Levy","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/DBP.0b013e31821bd06a","article-title":"The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members","volume":"32","author":"Wang","year":"2011","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s10803-013-1973-x","article-title":"Gastrointestinal problems in children with autism, developmental delays or typical development","volume":"44","author":"Chaidez","year":"2014","journal-title":"J. Autism Dev. Disord."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0140-6736(10)62304-5","article-title":"Anaemia in low-income and middle-income countries","volume":"378","author":"Balarajan","year":"2011","journal-title":"Lancet"},{"key":"ref_48","first-page":"11","article-title":"Hematologic disorders: Anemia","volume":"433","author":"Baltierra","year":"2015","journal-title":"FP Essent."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jpc.12483","article-title":"Iron deficiency in children with global developmental delay and autism spectrum disorder","volume":"50","author":"Sidrak","year":"2014","journal-title":"J. Paediatr. Child. Health"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-244X-13-161","article-title":"Association between psychiatric disorders and iron deficiency anemia among children and adolescents: A nationwide population-based study","volume":"13","author":"Chen","year":"2013","journal-title":"BMC Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12519-009-0052-z","article-title":"Co-assessment of iron, vitamin A and growth status to investigate anemia in preschool children in suburb Chongqing, China","volume":"5","author":"Chen","year":"2009","journal-title":"World J. Pediatr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1742-2094-9-201","article-title":"Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity","volume":"9","author":"Mostafa","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4103\/1817-1745.147574","article-title":"Is high prevalence of vitamin D deficiency evidence for autism disorder?: In a highly endogamous population","volume":"9","author":"Bener","year":"2014","journal-title":"J. Pediatr. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.mehy.2013.05.004","article-title":"Autism, will vitamin D treat core symptoms?","volume":"81","author":"Cannell","year":"2013","journal-title":"Med. Hypotheses"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1542\/peds.2014-2121","article-title":"Core symptoms of autism improved after vitamin D supplementation","volume":"135","author":"Jia","year":"2015","journal-title":"Pediatrics"},{"key":"ref_56","first-page":"366","article-title":"Efect of dietary vitamin A intake on plasma vitamin A concentration in preschool children of Banan District, Chongqing, China","volume":"46","author":"Peng","year":"2014","journal-title":"Beijing Da Xue Xue Bao"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1177\/0883073809333541","article-title":"Permanent visual loss due to dietary vitamin A deficiency in an autistic adolescent","volume":"24","author":"McAbee","year":"2009","journal-title":"J. Child Neurol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/0148607111436280","article-title":"Fried-potato diet causes vitamin A deficiency in an autistic child","volume":"36","author":"Tanoue","year":"2012","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1054\/mehy.1999.0999","article-title":"Is autism a G-alpha protein defect reversible with natural vitamin A?","volume":"54","author":"Megson","year":"2000","journal-title":"Med. Hypotheses"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1471-213X-7-138","article-title":"Retinoic Acid is a potential dorsalising signal in the late embryonic chick hindbrain","volume":"7","author":"Wilson","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"ref_61","first-page":"15","article-title":"Effects of early intervention on learning and memory in young rats of marginal vitamin A deficiency and it\u2019s mechanism","volume":"44","author":"Mao","year":"2006","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1017\/S1368980010000820","article-title":"Effect of biscuits fortified with different doses of vitamin A on indices of vitamin A status, haemoglobin and physical growth Levels of pre-school children in Chongqing","volume":"13","author":"Zhang","year":"2010","journal-title":"Public Health Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.earlhumdev.2009.02.001","article-title":"Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life","volume":"85","author":"Chen","year":"2009","journal-title":"Early Hum. Dev."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/5\/294\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:23:54Z","timestamp":1760210634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/5\/294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,14]]},"references-count":63,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5]]}},"alternative-id":["nu8050294"],"URL":"https:\/\/doi.org\/10.3390\/nu8050294","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,14]]}}}