{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:22:30Z","timestamp":1792815750803,"version":"4.5.0"},"reference-count":66,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Several in vitro and in vivo studies have reported the anti-inflammatory, anti-diabetic and anti-obesity effects of the flavonoid apigenin. However, the long-term supplementary effects of low-dose apigenin on obesity are unclear. Therefore, we investigated the protective effects of apigenin against obesity and related metabolic disturbances by exploring the metabolic and transcriptional responses in high-fat diet (HFD)-induced obese mice. C57BL\/6J mice were fed an HFD or apigenin (0.005%, w\/w)-supplemented HFD for 16 weeks. In HFD-fed mice, apigenin lowered plasma levels of free fatty acid, total cholesterol, apolipoprotein B and hepatic dysfunction markers and ameliorated hepatic steatosis and hepatomegaly, without altering food intake and adiposity. These effects were partly attributed to upregulated expression of genes regulating fatty acid oxidation, tricarboxylic acid cycle, oxidative phosphorylation, electron transport chain and cholesterol homeostasis, downregulated expression of lipolytic and lipogenic genes and decreased activities of enzymes responsible for triglyceride and cholesterol ester synthesis in the liver. Moreover, apigenin lowered plasma levels of pro-inflammatory mediators and fasting blood glucose. The anti-hyperglycemic effect of apigenin appeared to be related to decreased insulin resistance, hyperinsulinemia and hepatic gluconeogenic enzymes activities. Thus, apigenin can ameliorate HFD-induced comorbidities via metabolic and transcriptional modulations in the liver.<\/jats:p>","DOI":"10.3390\/nu8050305","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T20:43:57Z","timestamp":1463690637000},"page":"305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":137,"title":["Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice"],"prefix":"10.3390","volume":"8","author":[{"given":"Un","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Biotech Research Center, AMICOGEN INC., 64, Dongbu-ro 1259 beon-gil, Jinseong-myeon, Jinju-si, Gyeongsangnamdo 660-852, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Sook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Kyungpook National University, 1370 Sankyuk Dong Puk-ku, Daegu 702-701, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18C","DOI":"10.1016\/S0828-282X(10)71077-1","article-title":"Prevention of cardiovascular disease: Obesity, diabetes and the metabolic syndrome","volume":"26","author":"Padwal","year":"2010","journal-title":"Can. J. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.3390\/ijms15046184","article-title":"Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease","volume":"15","author":"Jung","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0140-6736(99)01046-6","article-title":"Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): A cohort study","volume":"353","author":"Schmidt","year":"1999","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000212742","article-title":"Inflammatory components of adipose tissue as target for treatment of metabolic syndrome","volume":"61","author":"Yu","year":"2009","journal-title":"Forum Nutr."},{"key":"ref_5","first-page":"489","article-title":"Non-alcoholic fatty liver disease severity, central fat mass and adinopectin: A close relationship","volume":"88","author":"Abenavoli","year":"2015","journal-title":"Clujul Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.nutres.2013.09.002","article-title":"Aortic cholesterol accumulation correlates with systemic inflammation but not hepatic and gonadal adipose tissue inflammation in low-density lipoprotein receptor null mice","volume":"33","author":"Wang","year":"2013","journal-title":"Nutr. Res."},{"key":"ref_7","first-page":"195","article-title":"Phytotherapy and NAFLD\u2014From goals and challenges to clinical practice","volume":"9","author":"Abenavoli","year":"2014","journal-title":"Rev. Recent Clin. Trials"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11095-010-0089-7","article-title":"Apigenin: A promising molecule for cancer prevention","volume":"27","author":"Shukla","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13346","DOI":"10.1021\/jf203490a","article-title":"Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells","volume":"59","author":"Ono","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2014.02.012","article-title":"Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion","volume":"101","author":"Kim","year":"2014","journal-title":"Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db12-1139","article-title":"Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome","volume":"62","author":"Escande","year":"2013","journal-title":"Diabetes"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s12272-010-1105-5","article-title":"Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL\/6J mice","volume":"33","author":"Myoung","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/mnfr.200700184","article-title":"Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db\/db mice","volume":"52","author":"Seo","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1017\/S0007114512000347","article-title":"Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice","volume":"108","author":"Cho","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1002\/mnfr.201100064","article-title":"Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL\/6J mice","volume":"55","author":"Do","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","article-title":"Use and abuse of HOMA modeling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4239\/wjd.v1.i2.36","article-title":"Surrogate markers of insulin resistance: A review","volume":"1","author":"Singh","year":"2010","journal-title":"World J. Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.00253.2003","article-title":"Novel concepts in insulin regulation of hepatic gluconeogenesis","volume":"285","author":"Barthel","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2337\/diabetes.49.8.1367","article-title":"Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: A quantitative study","volume":"49","author":"Gastaldelli","year":"2000","journal-title":"Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bumke-Vogt, C., Osterhoff, M.A., Borchert, A., Guzman-Perez, V., Sarem, Z., Birkenfeld, A.L., B\u00e4hr, V., and Pfeiffer, A.F. (2014). The flavones apigenin and luteolin induce FOXO1 translocation but inhibit gluconeogenic and lipogenic gene expression in human cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104321"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3844\/ajptsp.2014.39.52","article-title":"Apigenin causes biochemical modulation, GLUT4 and CD38 alterations to improve diabetes and to protect damages of some vital organs in experimental diabetes","volume":"9","author":"Hossain","year":"2014","journal-title":"Am. J. Pharmacol. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Polyzos, S.A., Kountouras, J., and Mantzoros, C.S. (2015). Adipokines in nonalcoholic fatty liver disease. Metabolism.","DOI":"10.1016\/j.metabol.2014.10.012"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2174\/1574887109666141216102458","article-title":"Role of adipokines and cytokines in non-alcoholic fatty liver disease","volume":"9","author":"Abenavoli","year":"2014","journal-title":"Rev. Recent Clin. Trials"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.2337\/diabetes.51.12.3391","article-title":"Interleukin-6 induces cellular insulin resistance in hepatocytes","volume":"51","author":"Senn","year":"2002","journal-title":"Diabetes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2337\/diacare.27.7.1699","article-title":"Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women","volume":"27","author":"Ryan","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1758-5996-6-47","article-title":"Synergistic anti-inflammatory effect: Simvastatin and pioglitazone reduce inflammatory markers of plasma and epicardial adipose tissue of coronary patients with metabolic syndrome","volume":"6","author":"Grosso","year":"2014","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/CIRCRESAHA.108.177105","article-title":"Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity","volume":"103","author":"Rocha","year":"2008","journal-title":"Circ. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.metabol.2012.01.018","article-title":"Systemic inflammation and insulin sensitivity in obese IFN-\u03b3 knockout mice","volume":"61","author":"White","year":"2012","journal-title":"Metabolism"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.4049\/jimmunol.179.10.7121","article-title":"Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-\u03baB through the suppression of p65 phosphorylation","volume":"179","author":"Nicholas","year":"2007","journal-title":"J. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"35361","DOI":"10.1074\/jbc.M504611200","article-title":"JNK and TNF-\u03b1 mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes","volume":"280","author":"Nguyen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3748\/wjg.v18.i8.727","article-title":"Role of cytokines and chemokines in non-alcoholic fatty liver disease","volume":"18","author":"Braunersreuther","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1476-511X-9-42","article-title":"The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"9","author":"Liu","year":"2010","journal-title":"Lipids Health Dis."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Li, H., Yokoyama, N., Yoshida, S., Tsutsumi, K., Hatakeyama, S., Sato, T., Ishihara, K., and Akiba, S. (2009). Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0008089"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cmet.2009.01.007","article-title":"TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1","volume":"9","author":"Ryu","year":"2009","journal-title":"Cell Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"26747","DOI":"10.1074\/jbc.273.41.26747","article-title":"Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates","volume":"273","author":"Anderson","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ejphar.2010.04.050","article-title":"Coenzyme A: Diacylglycerol acyltransferase 1 inhibitor ameliorates obesity, liver steatosis, and lipid metabolism abnormality in KKAy mice fed high-fat or high-carbohydrate diets","volume":"640","author":"Yamamoto","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14267","DOI":"10.1074\/jbc.M110.118422","article-title":"Inhibition of acyl-coenzyme A: Cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization","volume":"285","author":"Alger","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/hep.510300230","article-title":"Acyl-coenzyme A: Cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat","volume":"30","author":"Post","year":"1999","journal-title":"Hepatolohy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/01.ATV.14.9.1498","article-title":"Inhibition of hepatic ACAT decreases ApoB secretion in miniature pigs fed a cholesterol-free diet","volume":"14","author":"Huff","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cmet.2014.07.011","article-title":"Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization","volume":"20","author":"Jin","year":"2014","journal-title":"Cell Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.2337\/db05-1421","article-title":"Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha","volume":"55","author":"Dahlman","year":"2006","journal-title":"Diabetes"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.bbamcr.2011.01.015","article-title":"Targeting fatty acid and carbohydrate oxidation\u2014A novel therapeutic intervention in the ischemic and failing heart","volume":"1813","author":"Jaswal","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/oby.2009.49","article-title":"Hepatic gene expression in morbidly obese women: Implications for disease susceptibility","volume":"17","author":"Elam","year":"2009","journal-title":"Obesity"},{"key":"ref_44","first-page":"1285","article-title":"Quantitative proteomics study on the protective mechanism of phlorizin on hepatic damage in diabetic db\/db mice","volume":"5","author":"Lu","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1388-1981(00)00077-9","article-title":"Metabolism of highly unsaturated n-3 and n-6 fatty acids","volume":"1486","author":"Sprecher","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00394-014-0770-4","article-title":"The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis","volume":"54","author":"Santaella","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.ygeno.2007.08.004","article-title":"Gene expression profiling in livers of mice after acute inhibition of beta-oxidation","volume":"90","author":"Bloks","year":"2007","journal-title":"Genomics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3748\/wjg.15.1677","article-title":"Bile-acid-induced cell injury and protection","volume":"15","author":"Perez","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_49","first-page":"3322","article-title":"Diagnosis in bile acid-CoA: Amino acid N-acyltransferase deficiency","volume":"18","author":"Bull","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"27703","DOI":"10.1074\/jbc.M302128200","article-title":"Farnesoid X receptor regulates bile acid-amino acid conjugation","volume":"278","author":"Pircher","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1053\/j.gastro.2011.01.050","article-title":"NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5\/G8-mediated cholesterol transport","volume":"140","author":"Yamanashi","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"19316","DOI":"10.1073\/pnas.0910916106","article-title":"Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells","volume":"106","author":"Infante","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1210\/jc.2009-0931","article-title":"Independent confirmation of association between metabolic phenotypes of polycystic ovary syndrome and variation in the type 6 17beta-hydroxysteroid dehydrogenase gene","volume":"94","author":"Jones","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1038\/emboj.2011.320","article-title":"Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+\/\u2212 mice","volume":"30","author":"Morita","year":"2011","journal-title":"EMBO J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.3748\/wjg.v12.i40.6473","article-title":"Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis","volume":"12","author":"Takahara","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.2337\/diabetes.50.11.2591","article-title":"Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats","volume":"50","author":"Bandsma","year":"2001","journal-title":"Diabetes"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.bbalip.2010.02.009","article-title":"Systematic construction of a conceptual minimal model of plasma cholesterol levels based on knockout mouse phenotypes","volume":"1801","author":"Soffers","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1161\/01.ATV.0000252827.51626.89","article-title":"Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase","volume":"27","author":"Shimamura","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"19751","DOI":"10.1073\/pnas.1217552109","article-title":"Atypical angiopoietin-like protein that regulates ANGPTL3","volume":"109","author":"Quagliarini","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s11695-008-9739-9","article-title":"Increased expression and activity of hepatic lipase in the liver of morbidly obese adult patients in relation to lipid content","volume":"19","author":"Pardina","year":"2008","journal-title":"Obes. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1073\/pnas.121164498","article-title":"Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance","volume":"98","author":"Kim","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2007.05.005","article-title":"Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver","volume":"6","author":"Monetti","year":"2007","journal-title":"Cell Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1096\/fj.10-173716","article-title":"Role for PPAR\u03b3 in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts","volume":"25","author":"Titos","year":"2011","journal-title":"FASEB J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/hep.25611","article-title":"Cidea promotes hepatic steatosis by sensing dietary fatty acids","volume":"56","author":"Zhou","year":"2012","journal-title":"Hepatology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cmet.2007.10.014","article-title":"Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis","volume":"6","author":"Miyazaki","year":"2007","journal-title":"Cell Metab."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/5\/305\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:24:10Z","timestamp":1760210650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/5\/305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,19]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5]]}},"alternative-id":["nu8050305"],"URL":"https:\/\/doi.org\/10.3390\/nu8050305","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,19]]}}}