{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:10:38Z","timestamp":1768687838693,"version":"3.49.0"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Projects of National Natural Science Foundation of China","award":["81437052"],"award-info":[{"award-number":["81437052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The association between elevated body mass index (BMI) and risk of death has been reported in many studies. However, the association between BMI and all-cause mortality for hypertensive Chinese adults remains unclear. We conducted a post-hoc analysis using data from the China Stroke Primary Prevention Trial (CSPPT). Cox regression analysis was performed to determine the significance of the association of BMI with all-cause mortality. During a mean follow-up duration of 4.5 years, 622 deaths (3.0%) occurred among the 20,694 participants aged 45\u201375 years. A reversed J-shaped relationship was observed between BMI and all-cause mortality. The hazard ratios (HRs) for underweight (&lt;18.5 kg\/m2), overweight (24.0\u201327.9 kg\/m2), and obesity (\u226528.0 kg\/m2) were calculated relative to normal weight (18.5\u201323.9 kg\/m2). The summary HRs were 1.56 (95% CI, 1.11\u20132.18) for underweight, 0.78 (95% CI 0.64\u20130.95) for overweight and 0.64 (95% CI, 0.48\u20130.85) for obesity. In sex-age-specific analyses, participants over 60 years of age had optimal BMI in the obesity classification and the results were consistent in both males and females. Relative to normal weight, underweight was associated with significantly higher mortality. Excessive weight was not associated with increased risk of mortality. Chinese hypertensive adults had the lowest mortality in grade 1 obesity.<\/jats:p>","DOI":"10.3390\/nu8060384","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T18:29:50Z","timestamp":1466706590000},"page":"384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association between Body Mass Index and All-Cause Mortality in Hypertensive Adults: Results from the China Stroke Primary Prevention Trial (CSPPT)"],"prefix":"10.3390","volume":"8","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin-Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Hui","family":"Qin","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hou-Xun","family":"Xing","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen-Fu","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Feng","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1475-6773.2007.00801.x","article-title":"The Financial Burden of Overweight and Obesity among Elderly Americans: The Dynamics of Weight, Longevity, and Health Care Cost","volume":"43","author":"Yang","year":"2008","journal-title":"Health Serv. Res."},{"key":"ref_2","unstructured":"World Health Organization WHO Global Infobase, 2014. Available online: http:\/\/www.who.int\/gho\/ncd\/risk_factors\/overweight_text\/en\/."},{"key":"ref_3","unstructured":"World Health Organization (1995). Physical Status: The Use and Interpretation of Anthropometry, World Health Organization. Report of a WHO Expert Committee."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1001\/jama.293.15.1861","article-title":"Excess deaths associated with underweight, overweight, and obesity","volume":"293","author":"Flegal","year":"2005","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.2012.113905","article-title":"Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-analysis","volume":"309","author":"Flegal","year":"2013","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1056\/NEJMoa042135","article-title":"Adiposity as Compared with Physical Activity in Predicting Mortality among Women","volume":"351","author":"Hu","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3945\/ajcn.113.068122","article-title":"BMI and all-cause mortality in older adults: A meta-analysis","volume":"99","author":"Winter","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1056\/NEJMoa1010679","article-title":"Association between body-mass index and risk of death in more than 1 million Asians","volume":"364","author":"Zheng","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam","year":"2005","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"WHO Expert Consultation (2004). Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet, 363, 157\u2013163.","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"ref_11","first-page":"1","article-title":"The guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"17","author":"Chen","year":"2004","journal-title":"Biomed. Environ. Sci."},{"key":"ref_12","first-page":"579","article-title":"2010 Chinese guidelines for the management of hypertension","volume":"39","author":"Liu","year":"2011","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China","volume":"313","author":"Huo","year":"2015","journal-title":"JAMA"},{"key":"ref_14","unstructured":"EmpowerStats. Available online: http:\/\/www.empowerstats.com."},{"key":"ref_15","unstructured":"R Software, Verson 3.2.1. Available online: http:\/\/www.R-project.org\/."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1467-789X.2006.00248.x","article-title":"Elevated body mass index and mortality risk in the elderly","volume":"8","author":"Janssen","year":"2007","journal-title":"Obes. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1532-5415.2001.49150.x","article-title":"Longitudinal changes in body mass index and body composition over 3 years and relationship to health outcomes in Hong Kong Chinese age 70 and older","volume":"49","author":"Woo","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1017\/S136898001400281X","article-title":"BMI and all-cause mortality among middle-aged and older adults in Taiwan: A population-based cohort study","volume":"18","author":"Chung","year":"2015","journal-title":"Public Health. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1111\/j.1532-5415.2010.03148.x","article-title":"Larger Body Mass Index and Waist Circumference Are Associated with Lower Mortality in Chinese Long-Term Care Facility Residents","volume":"58","author":"Lin","year":"2010","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jamda.2013.12.081","article-title":"Obesity Can Benefit Survival\u2014A 9-Year Prospective Study in 1614 Chinese Nursing Home Residents","volume":"15","author":"Lee","year":"2014","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0140-6736(06)69251-9","article-title":"Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies","volume":"368","author":"Montori","year":"2006","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1001\/jama.2010.339","article-title":"Quality of care among obese patients","volume":"303","author":"Chang","year":"2010","journal-title":"JAMA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1001\/archinte.166.14.1498","article-title":"Obesity, physical activity, and mortality in a prospective Chinese elderly cohort","volume":"166","author":"Schooling","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/ije\/dyv138","article-title":"Sex-age-specific association of body mass index with all-cause mortality among 12.8 million Korean adults: A prospective cohort study","volume":"44","author":"Yi","year":"2015","journal-title":"Int. J. Epidemiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/6\/384\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:24:27Z","timestamp":1760210667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/6\/384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6]]}},"alternative-id":["nu8060384"],"URL":"https:\/\/doi.org\/10.3390\/nu8060384","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,22]]}}}