{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:23:58Z","timestamp":1765959838658,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Technology R&amp;D Program of China","award":["2012BAI02B03"],"award-info":[{"award-number":["2012BAI02B03"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172755"],"award-info":[{"award-number":["81172755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds for the Central Universities and Program for Zhejiang Leading Team of Science and Technology Innovation","award":["2010R50050"],"award-info":[{"award-number":["2010R50050"]}]},{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Few studies have described the characteristics of metabolically healthy individuals with excess fat in the Chinese population. This study aimed to prospectively investigate the natural course of metabolically healthy overweight\/obese (MH-OW\/OB) adults, and to assess the impact of weight change on developing metabolic abnormalities. During 2009\u20132010, 525 subjects without any metabolic abnormalities or other obesity-related diseases were evaluated and reevaluated after 5 years. The subjects were categorized into two groups of overweight\/obese and normal weight based on the criteria of BMI by 24.0 at baseline. At follow-up, the MH-OW\/OB subjects had a significantly increased risk of developing metabolically abnormalities compared with metabolically healthy normal-weight (MH-NW) individuals (risk ratio: 1.35, 95% confidence interval: 1.17\u20131.49, p value &lt; 0.001). In the groups of weight gain and weight maintenance, the MH-OW\/OB subjects was associated with a larger increase in fasting glucose, triglycerides, systolic blood pressure, diastolic blood pressure and decrease in high-density lipoprotein cholesterol comparing with MH-NW subjects. In the weight loss group, no significant difference of changes of metabolic parameters was observed between MH-OW\/OB and MH-NW adults. This study verifies that MH-OW\/OB are different from MH-NW subjects. Weight management is needed for all individuals since weight change has a significant effect on metabolic health without considering the impact of weight change according to weight status.<\/jats:p>","DOI":"10.3390\/nu8070430","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T11:08:05Z","timestamp":1468580885000},"page":"430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Natural Course of Metabolically Healthy Overweight\/Obese Subjects and the Impact of Weight Change"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-7597","authenticated-orcid":false,"given":"Ruizhi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Institute of Cardiovascular Diseases, Zhejiang Putuo Hospital, Zhoushan 316100, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongxiang Center for Disease Control and Prevention, Tongxiang 314500, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feixia","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310000, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/obr.12163","article-title":"Peripheral targets in obesity treatment: A comprehensive update","volume":"15","author":"Chatzigeorgiou","year":"2014","journal-title":"Obes. 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