{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:42:24Z","timestamp":1785822144681,"version":"3.56.0"},"reference-count":42,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070797"],"award-info":[{"award-number":["81070797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and Aims: This study was designed to investigate a relatively optimum dose of partial enteral nutrition (PEN) which effectively attenuates intestinal barrier dysfunction initiated by ischemia\/reperfusion injury (IRI). Methods: In experiment 1, 60 male Sprague-Dawley (SD) rats were subjected to intestinal IRI and assigned to six groups according to the different proportion of EN administrations: namely total parenteral nutrition (TPN or 0%EN), 10%EN, 20%EN, 40%EN, 60%EN, and total enteral nutrition (TEN or 100%) groups, the deficits of intraluminal calorie were supplemented by PN. In experiment 2, 50 male SD rats were subjected to intestinal IRI and divided into five groups based on the results of experiment 1: TPN, TEN, 20%EN, TPN plus pretreatment with NF-\u03baB antagonist 30 min before IRI (TPN+PDTC), and TPN plus pretreatment with HIF-1\u03b1 antagonist 30 min before IRI (TPN+YC-1) groups. Results: In experiment 1, previous IRI combined with subsequent EN shortage disrupted the structure of intestinal epithelial cell and tight junctions (TJs). While 20% dose of EN had an obviously protective effect on these detrimental consequences. In experiment 2, compared with TPN only, 20%EN exerted a significant protection of barrier function of intestinal epithelium. Analogous results were observed when TPN combined with specific NF-\u03baB\/HIF-1\u03b1 inhibitors (PDTC and YC-1). Meanwhile, the expression of NF-\u03baB\/HIF-1\u03b1 had a similar trend among the groups. Conclusions: Our findings indicate that 20%EN is the minimally effective dosage of EN which promotes the recovery of intestinal barrier function after IRI in a rat model. Furthermore, we discreetly speculate that this benefit is, at least partly, related to NF-\u03baB\/HIF-1\u03b1 pathway expression.<\/jats:p>","DOI":"10.3390\/nu8080502","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T10:23:21Z","timestamp":1471429401000},"page":"502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Partial Enteral Nutrition Mitigated Ischemia\/Reperfusion-Induced Damage of Rat Small Intestinal Barrier"],"prefix":"10.3390","volume":"8","author":[{"given":"Chao","family":"Wu","sequence":"first","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"},{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojun","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University and Model Animal Research Center, National Resource Center for Mutant Mice, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejin","family":"Gao","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieshou","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.amjsurg.2006.02.001","article-title":"Evaluation of intestinal mucosal permeability function in patients with acute pancreatitis","volume":"192","author":"Nagpal","year":"2006","journal-title":"Am. 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