{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:38:45Z","timestamp":1771720725105,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2016,10,23]],"date-time":"2016-10-23T00:00:00Z","timestamp":1477180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"n\/a"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Reduced dietary protein intake in malnourished patients with chronic kidney disease (CKD) may be associated with adverse clinical outcomes, which may mask any efficacy of a low-protein diet. The study included 126 patients with CKD who attended a dedicated dietary counseling clinic in 2005\u20132009 and were systematically followed until January 2015. Of these patients, 20 (15.9%) had moderate or severe nutrition-related risk of geriatric nutritional risk index (GNRI) &lt; 92; these patients were more likely to be older, have a greater proteinuria, and have lower body mass index and serum albumin concentration. Dietary protein intake was significantly lower in older patients (r = \u22120.33, p &lt; 0.001) and those with lower glomerular filtration rate (r = 0.47, p &lt; 0.001). The non-protein to nitrogen calorie ratio was independently associated with GNRI. Reduced GNRI was significantly associated with mortality (hazard ratio (HR) = 4.94; 95% confidence interval (CI) = 1.61\u201315.42, p = 0.012) and cardiovascular events (HR = 9.37; 95% CI = 2.49\u201337.34, p = 0.006), but not with adverse renal outcomes. Restricting protein intake may be harmful to patients with any nutrition-related risk, suggesting that improvement of nutritional status should be a high priority.<\/jats:p>","DOI":"10.3390\/nu8100662","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T10:46:39Z","timestamp":1477305999000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Association between Low Dietary Protein Intake and Geriatric Nutrition Risk Index in Patients with Chronic Kidney Disease: A Retrospective Single-Center Cohort Study"],"prefix":"10.3390","volume":"8","author":[{"given":"Aki","family":"Kiuchi","sequence":"first","affiliation":[{"name":"Department of Nephrology, Omori Medical Center, School of Medicine, Toho University, Tokyo 143-8541, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-9498","authenticated-orcid":false,"given":"Yasushi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sakura Medical Center, School of Medicine, Toho University, 564-1, Shimoshizu, Sakura, Chiba 285-8741, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reibin","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Omori Medical Center, School of Medicine, Toho University, Tokyo 143-8541, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Omori Medical Center, School of Medicine, Toho University, Tokyo 143-8541, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonoo","family":"Mizuiri","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Ichiyokai Harada Hospital, Hiroshima 731-5134, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoko","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Omori Medical Center, Toho University, Tokyo 143-8541, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-3801","authenticated-orcid":false,"given":"Atsushi","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Omori Medical Center, School of Medicine, Toho University, Tokyo 143-8541, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-8377","authenticated-orcid":false,"given":"Ken","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Omori Medical Center, School of Medicine, Toho University, Tokyo 143-8541, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2013). 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