{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:38:29Z","timestamp":1789720709242,"version":"4.0.1"},"reference-count":450,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa de Apoio ao Desenvolvimento Cient\u00edfico da Faculdade de Ci\u00eancias Farmac\u00eauticas da UNESP (PADC-FCF UNESP)"},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["2015\/19531-1; 2016\/08470-4; 2015\/21252-3; 2014\/14980-0; 2014\/02240-1 and 2014\/24811-0"],"award-info":[{"award-number":["2015\/19531-1; 2016\/08470-4; 2015\/21252-3; 2014\/14980-0; 2014\/02240-1 and 2014\/24811-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds. Molecular targets and cellular pathways will be described. Furthermore, we also discussed the ability of these natural products act as chemopreventive and its use in association with other anticancer drugs.<\/jats:p>","DOI":"10.3390\/nu8110628","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T10:51:39Z","timestamp":1478775099000},"page":"628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Unraveling the Anticancer Effect of Curcumin and Resveratrol"],"prefix":"10.3390","volume":"8","author":[{"given":"Aline","family":"Pavan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, UNESP\u2013Univ Estadual Paulista, Araraquara 14800903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-9856","authenticated-orcid":false,"given":"Gabriel","family":"Silva","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, UNESP\u2013Univ Estadual Paulista, Araraquara 14800903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Jornada","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, UNESP\u2013Univ Estadual Paulista, Araraquara 14800903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Chiba","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, UNESP\u2013Univ Estadual Paulista, Araraquara 14800903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-5466","authenticated-orcid":false,"given":"Guilherme","family":"Fernandes","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, UNESP\u2013Univ Estadual Paulista, Araraquara 14800903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung","family":"Man Chin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, UNESP\u2013Univ Estadual Paulista, Araraquara 14800903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, UNESP\u2013Univ Estadual Paulista, Araraquara 14800903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/632959","article-title":"Polyphenols: Key issues involved in chemoprevention of prostate cancer","volume":"2012","author":"Cimino","year":"2012","journal-title":"Oxid. 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