{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:30:56Z","timestamp":1776101456890,"version":"3.50.1"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 356124-2013"],"award-info":[{"award-number":["RGPIN 356124-2013"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["222084"],"award-info":[{"award-number":["222084"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lawson Family Chair in Microbiome Nutrition Research","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Obesity is associated with systemic inflammation and impaired bone health. Vitamin D regulates bone metabolism, and has anti-inflammatory properties and epigenetic effects. We showed that exposure to high dietary vitamin D during pregnancy and lactation beneficially programs serum concentration of lipopolysaccharide (LPS) and bone structure in male offspring fed an obesogenic diet. Here we assessed if this effect is also apparent in females. C57BL\/6J dams were fed AIN93G diet with high (5000 IU\/kg diet) or low (25 IU\/kg diet) vitamin D during pregnancy and lactation. Post-weaning, female offspring remained on their respective vitamin D level or were switched and fed a high fat and sucrose diet (44.2% fat, 19.8% sucrose) until age seven months when glucose response, adiposity, serum LPS, and bone mineral, trabecular and cortical structure, and biomechanical strength properties of femur and vertebra were assessed. There was no evidence for a programming effect of vitamin D for any outcomes. However, females exposed to a high vitamin D diet post-weaning had higher bone mineral content (p = 0.037) and density (p = 0.015) of lumbar vertebra. This post-weaning benefit suggests that in females, bone mineral accrual but not bone structure is compromised with low vitamin D status in utero until weaning in an obesogenic context.<\/jats:p>","DOI":"10.3390\/nu8110675","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T05:47:55Z","timestamp":1477460875000},"page":"675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Maternal Dietary Vitamin D Does Not Program Systemic Inflammation and Bone Health in Adult Female Mice Fed an Obesogenic Diet"],"prefix":"10.3390","volume":"8","author":[{"given":"Christopher","family":"Villa","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijun","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-6842","authenticated-orcid":false,"given":"Sandra","family":"Sacco","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Taibi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9518-9608","authenticated-orcid":false,"given":"Wendy","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada"},{"name":"Department of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Comelli","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada"},{"name":"Centre for Child Nutrition and Health, Faculty of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization Obesity and Overweight: Fact Sheet. 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