{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:53:53Z","timestamp":1762955633660,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,10,29]],"date-time":"2016-10-29T00:00:00Z","timestamp":1477699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK072488","CA190710","U24DK100469","UL1TR000135"],"award-info":[{"award-number":["P30DK072488","CA190710","U24DK100469","UL1TR000135"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nutrient tranters (NT) facilitate nutrient absorption and contribute to the regulation of circulating nutrients. In this cross-sectional study, we determined the associations between the level of obesity; mRNA abundance for NTs; and serum concentrations of amino acids, short-chain fatty acids, and glucose in patients with morbid obesity undergoing a Roux-en-Y gastric bypass. Proximal jejunal samples were obtained at the time of surgery from 42 patients (90% female, age = 42.6 \u00b1 11.9 years, pre-operative body mass index (BMI) = 55.5 \u00b1 11.3 kg\/m2) undergoing a Roux-en-Y gastric bypass. RNA was extracted from the jejunal mucosa and quantitative real-time\u2013PCR was performed for the NTs studied. BMI negatively correlated with jejunal mRNA abundance of the amino acid NTs TauT (r = \u22120.625, p &lt; 0.0001), ASCT2 (r = \u22120.320, p = 0.039), LAT1 (r = \u22120.304, p = 0.05). BMI positively correlated with jejunal mRNA abundance of the lactate\/short-chain fatty acid NT SMCT1 (r = 0.543, p = 0.0002). Serum concentrations of the short-chain fatty acids, butyric, valeric, and isocaproic acid correlated positively with BMI (n = 30) (r = 0.45, r = 0.44, r = 0.36, p \u2264 0.05; respectively). Lower jejunal mRNA abundance for the amino acid NTs TauT, ASCT2, and LAT1 could protect against further obesity-related elevations in circulating amino acids. The positive correlation between BMI and the jejunal mRNA abundance of the high-affinity short-chain fatty acid\/monocarboxylate transporter SMCT1 is intriguing and requires further investigation.<\/jats:p>","DOI":"10.3390\/nu8110683","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T11:09:46Z","timestamp":1477912186000},"page":"683","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-9523","authenticated-orcid":false,"given":"Brian","family":"Irving","sequence":"first","affiliation":[{"name":"Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wood","sequence":"additional","affiliation":[{"name":"Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bennotti","sequence":"additional","affiliation":[{"name":"Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellappan","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Medicine Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Lent","sequence":"additional","affiliation":[{"name":"Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Petrick","sequence":"additional","affiliation":[{"name":"Surgery, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Gabrielsen","sequence":"additional","affiliation":[{"name":"Surgery, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Strodel","sequence":"additional","affiliation":[{"name":"Surgery, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Gerhard","sequence":"additional","affiliation":[{"name":"Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"},{"name":"Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine, Temple University, Medicine Education &amp; Research Building 3500 N. Broad St., Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Still","sequence":"additional","affiliation":[{"name":"Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadivel","family":"Ganapathy","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rolston","sequence":"additional","affiliation":[{"name":"Obesity Institute, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"},{"name":"Internal Medicine, Geisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.2337\/dc08-2075","article-title":"Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women","volume":"32","author":"Huffman","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Spanier, B., Lasch, K., Marsch, S., Benner, J., Liao, W., Hu, H., Kienberger, H., Eisenreich, W., and Daniel, H. 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