{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:51:00Z","timestamp":1776430260209,"version":"3.51.2"},"reference-count":84,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R42DK097976"],"award-info":[{"award-number":["R42DK097976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01DK083929"],"award-info":[{"award-number":["R01DK083929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01DA042524"],"award-info":[{"award-number":["R01DA042524"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["OD011104-54"],"award-info":[{"award-number":["OD011104-54"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The composition of the gut microbiome reflects the overall health status of the host. In this study, stool samples representing the gut microbiomes from 6 gluten-sensitive (GS) captive juvenile rhesus macaques were compared with those from 6 healthy, age- and diet-matched peers. A total of 48 samples representing both groups were studied using V4 16S rRNA gene DNA analysis. Samples from GS macaques were further characterized based on type of diet administered: conventional monkey chow, i.e., wheat gluten-containing diet (GD), gluten-free diet (GFD), barley gluten-derived diet (BOMI) and reduced gluten barley-derived diet (RGB). It was hypothesized that the GD diet would lower the gut microbial diversity in GS macaques. This is the first report illustrating the reduction of gut microbial alpha-diversity (p &lt; 0.05) following the consumption of dietary gluten in GS macaques. Selected bacterial families (e.g., Streptococcaceae and Lactobacillaceae) were enriched in GS macaques while Coriobacteriaceae was enriched in healthy animals. Within several weeks after the replacement of the GD by the GFD diet, the composition (beta-diversity) of gut microbiome in GS macaques started to change (p = 0.011) towards that of a normal macaque. Significance for alpha-diversity however, was not reached by the day 70 when the feeding experiment ended. Several inflammation-associated microRNAs (miR-203, -204, -23a, -23b and -29b) were upregulated (p &lt; 0.05) in jejunum of 4 biopsied GS macaques fed GD with predicted binding sites on 16S ribosomal RNA of Lactobacillus reuteri (accession number: NR_025911), Prevotella stercorea (NR_041364) and Streptococcus luteciae (AJ297218) that were overrepresented in feces. Additionally, claudin-1, a validated tight junction protein target of miR-29b was significantly downregulated in jejunal epithelium of GS macaques. Taken together, we predict that with the introduction of effective treatments in future studies the diversity of gut microbiomes in GS macaques will approach those of healthy individuals. Further studies are needed to elucidate the regulatory pathways of inflammatory miRNAs in intestinal mucosa of GS macaques and to correlate their expression with gut dysbiosis.<\/jats:p>","DOI":"10.3390\/nu8110684","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T10:14:04Z","timestamp":1477649644000},"page":"684","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Dietary Gluten-Induced Gut Dysbiosis Is Accompanied by Selective Upregulation of microRNAs with Intestinal Tight Junction and Bacteria-Binding Motifs in Rhesus Macaque Model of Celiac Disease"],"prefix":"10.3390","volume":"8","author":[{"given":"Mahesh","family":"Mohan","sequence":"first","affiliation":[{"name":"Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl-Emiliane","family":"Chow","sequence":"additional","affiliation":[{"name":"Second Genome Inc., San Francisco, CA 94080, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Ryan","sequence":"additional","affiliation":[{"name":"Second Genome Inc., San Francisco, CA 94080, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Chan","sequence":"additional","affiliation":[{"name":"Second Genome Inc., San Francisco, CA 94080, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Dufour","sequence":"additional","affiliation":[{"name":"Division of Veterinary Resources, Tulane National Primate Research Center, Covington, LA 70433, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pyone","family":"Aye","sequence":"additional","affiliation":[{"name":"Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA"},{"name":"Division of Veterinary Resources, Tulane National Primate Research Center, Covington, LA 70433, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Division of Veterinary Resources, Tulane National Primate Research Center, Covington, LA 70433, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0714-2445","authenticated-orcid":false,"given":"Charles","family":"Moehs","sequence":"additional","affiliation":[{"name":"Arcadia Biosciences Inc., Seattle, WA 98119, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-2719","authenticated-orcid":false,"given":"Karol","family":"Sestak","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA"},{"name":"PreCliniTria LLC, Mandeville, LA 70471, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.coi.2011.11.002","article-title":"Microbiota in autoimmunity and tolerance","volume":"23","author":"Atarashi","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/00365521.2014.898326","article-title":"Surface area of the digestive tract-revisited","volume":"49","author":"Helander","year":"2014","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1126\/science.288.5464.287","article-title":"Infectious history","volume":"288","author":"Lederberg","year":"2000","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project: Exploring the microbial part of ourselves in a changing world","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1073\/pnas.0712038105","article-title":"Symbiotic gut microbes modulate human metabolic phenotypes","volume":"105","author":"Li","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature06245","article-title":"An ecological and evolutionary perspective on human-microbe mutualism and disease","volume":"449","author":"Dethlefsen","year":"2007","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.1155725","article-title":"Evolution of mammals and their gut microbes","volume":"320","author":"Ley","year":"2008","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1136\/gut.2007.133603","article-title":"High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota","volume":"57","author":"Zoetendal","year":"2008","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tyakht, A.V., Kostryukova, E.S., Popenko, A.S., Belenikin, M.S., Pavlenko, A.V., Larin, A.K., Karpova, I.Y., Selezneva, O.V., Semashko, T.A., and Ospanova, E.A. (2013). Human gut microbiota community structures in urban and rural populations in Russia. Nat. Commun.","DOI":"10.1038\/ncomms3469"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1128\/AEM.00342-14","article-title":"Establishment of intestinal microbiota during early life: A longitudinal, explorative study of a large cohort of Danish infants","volume":"80","author":"Skov","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ma, J., Prince, A.L., Bader, D., Hu, M., Ganu, R., Baquero, K., Blundell, P., Harris, R.A., Frias, A.E., and Grove, K.L. (2014). High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model. Nat. Commun., 5.","DOI":"10.1038\/ncomms4889"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1038\/ncomms4654","article-title":"Gut microbiome of the Hadza hunter-gatherers","volume":"5","author":"Schnorr","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1186\/gb-2014-15-7-r89","article-title":"Host lifestyle affects human microbiota on daily timescales","volume":"15","author":"David","year":"2014","journal-title":"Genome Biol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Martin, M.E., Bhatnagar, S., George, M.D., Paster, B.J., Canfield, D.R., Eisen, J.A., and Solnick, J.V. (2013). The impact of Helicobacter pylori infection on the gastric microbiota of the rhesus macaque. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076375"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"McKenna, P., Hoffmann, C., Minkah, N., Aye, P.P., Lackner, A., Liu, Z., Lozupone, C.A., Hamady, M., Knight, R., and Bushman, F.D. (2008). The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.0040020"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14691","DOI":"10.1073\/pnas.1005963107","article-title":"Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa","volume":"107","author":"Cavalieri","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3945\/ajcn.112.056689","article-title":"Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans","volume":"98","author":"Ou","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"252ra120","DOI":"10.1126\/scitranslmed.3008791","article-title":"Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems","volume":"6","author":"Ardeshir","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Broadhurst, M.J., Ardeshir, A., Kanwar, B., Mirpuri, J., Gundra, U.M., Leung, J.M., Wiens, K.E., Vujkovic-Cvijin, I., Kim, C.C., and Yarovinsky, F. (2012). Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1003000"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1513\/AnnalsATS.201306-208MG","article-title":"Inulin treatment leads to changes in intestinal microbiota and resolution of idiopathic chronic diarrhea in rhesus macaques","volume":"11","author":"Ardeshir","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.chom.2007.06.010","article-title":"Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae","volume":"2","author":"Lupp","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/MOG.0b013e328339536b","article-title":"The intestinal microbiota in inflammatory bowel diseases: Time to connect with the host","volume":"26","author":"Sokol","year":"2010","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1186\/gb-2012-13-9-r79","article-title":"Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment","volume":"13","author":"Morgan","year":"2012","journal-title":"Genome Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tong, M., Li, X., Parfrey, L.W., Roth, B., Ippoliti, A., Wei, B., Borneman, J., McGovern, D.P., Frank, D.N., and Li, E. (2013). A modular organization of the human intestinal mucosal microbiota and its association with Inflammatory Bowel Disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0080702"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1757-4749-6-22","article-title":"Characterization of bacterial community shift in human Ulcerative Colitis patients revealed by Illumina based 16S rRNA gene amplicon sequencing","volume":"6","author":"Walujkar","year":"2014","journal-title":"Gut Path."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1099\/jmm.0.46198-0","article-title":"Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis","volume":"55","author":"Lucke","year":"2006","journal-title":"J. Med. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1017\/S0007114509371767","article-title":"Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects","volume":"102","author":"Nadal","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"De Palma, G., Capilla, A., Nova, E., Castillejo, G., Varea, V., Pozo, T., Garrote, J.A., Polanco, I., L\u00f3pez, A., and Ribes-Koninckx, C. (2012). Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: The PROFICEL study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030791"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sellitto, M., Bai, G., Serena, G., Fricke, W.F., Sturgeon, C., Gajer, P., White, J.R., Koenig, S.S., Sakamoto, J., and Boothe, D. (2012). Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033387"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cheng, J., Kalliom\u00e4ki, M., Heilig, H.G., Palva, A., L\u00e4hteenoja, H., de Vos, W.M., Saloj\u00e4rvi, J., and Satokari, R. (2013). Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease. BMC Gastroenterol., 13.","DOI":"10.1186\/1471-230X-13-113"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.1128\/AEM.00869-13","article-title":"Duodenal-mucosal bacteria associated with celiac disease in children","volume":"79","author":"Donat","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1651-2227.2000.tb01210.x","article-title":"Epidemic of coeliac disease in Swedish children","volume":"89","author":"Ivarsson","year":"2000","journal-title":"Acta Paediatr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1038\/ajg.2009.524","article-title":"Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease","volume":"104","author":"Ou","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sj\u00f6berg, V., Sandstr\u00f6m, O., Hedberg, M., Hammarstr\u00f6m, S., Hernell, O., and Hammarstr\u00f6m, M.L. (2013). Intestinal T-cell responses in celiac disease\u2014Impact of celiac disease associated bacteria. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053414"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/1574-6941.12295","article-title":"Diversity of the cultivable human gut microbiome involved in gluten metabolism: Isolation of microorganisms with potential interest for coeliac disease","volume":"88","author":"Caminero","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ajg.2016.95","article-title":"Metagenomics reveals dysbiosis and a potentially pathogenic N. flavescens strain in duodenum of adult celiac patients","volume":"111","author":"Casaburi","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.clim.2013.02.012","article-title":"Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease","volume":"147","author":"Xu","year":"2013","journal-title":"Clin. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chom.2015.12.005","article-title":"The Host Shapes the Gut Microbiota via Fecal MicroRNA","volume":"19","author":"Liu","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.3390\/nu7031657","article-title":"The effects of reduced gluten barley diet on humoral and cell-mediated systemic immune responses of gluten-sensitive rhesus macaques","volume":"7","author":"Sestak","year":"2015","journal-title":"Nutrients"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1128\/IAI.71.7.4079-4086.2003","article-title":"Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques","volume":"71","author":"Sestak","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu8070401","article-title":"Supplementation of reduced gluten barley diet with oral prolyl endopeptidase effectively abrogates enteropathy-associated changes in gluten-sensitive macaques","volume":"8","author":"Sestak","year":"2016","journal-title":"Nutrients"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.1000080107","article-title":"Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample","volume":"108","author":"Caporaso","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea","volume":"6","author":"McDonald","year":"2012","journal-title":"ISME J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: Highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"DeSantis","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_50","first-page":"32","article-title":"A new method for non-parametric multivariate analysis of variance","volume":"26","author":"Anderson","year":"2001","journal-title":"Aust. Ecol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Love, M., Huber, W., and Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol., 15.","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"McMurdie, P.J., and Holmes, S. (2014). Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible. PLoS Comput. Biol., 10.","DOI":"10.1371\/journal.pcbi.1003531"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4049\/jimmunol.1401447","article-title":"Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques","volume":"194","author":"Mohan","year":"2015","journal-title":"J. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1128\/JVI.01754-14","article-title":"Chronic administration of \u03949-tetrahydrocannabinol induces intestinal anti-inflammatory microRNA expression during acute SIV infection of rhesus macaques","volume":"89","author":"Chandra","year":"2015","journal-title":"J. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.gastro.2014.09.037","article-title":"MicroRNA 29 targets nuclear factor-\u03baB-repressing factor and Claudin 1 to increase intestinal permeability","volume":"148","author":"Zhou","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.bbrc.2014.06.125","article-title":"MicroRNA-203 accelerates apoptosis in LPS-stimulated alveolar epithelial cells by targeting PIK3CA","volume":"450","author":"Ke","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1097\/MIB.0000000000000478","article-title":"MicroRNAs Classify Different Disease Behavior Phenotypes of Crohn\u2019s Disease and May Have Prognostic Utility","volume":"21","author":"Peck","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1167\/iovs.10-6708","article-title":"Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells","volume":"52","author":"Li","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.immuni.2016.01.007","article-title":"MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium","volume":"44","author":"Zhang","year":"2016","journal-title":"Immunity"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-\u03b1","volume":"18","author":"Zhu","year":"2012","journal-title":"Nat. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/1756283X14547360","article-title":"The emerging role of miRNAs in inflammatory bowel disease: A review","volume":"8","author":"Chapman","year":"2015","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible","volume":"34","author":"Rehmsmeier","year":"2006","journal-title":"Nucl. Acids Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e944446","DOI":"10.4161\/21688362.2014.944446","article-title":"MicroRNAs regulate tight junction proteins and modulate epithelial\/endothelial barrier functions","volume":"2","author":"Cichon","year":"2014","journal-title":"Tissue Barriers"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e28320","DOI":"10.4161\/tisb.28320","article-title":"Posttranscriptional Regulation of Intestinal Epithelial Tight Junction Barrier by RNA-binding Proteins and microRNAs","volume":"2","author":"Yang","year":"2014","journal-title":"Tissue Barriers"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1023\/A:1022673226324","article-title":"Biological control of maize seed pathogenic fungi by use of actinomycetes","volume":"48","author":"Bressan","year":"2003","journal-title":"BioControl"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Agarwal, V., Bell, G.W., Nam, J.W., and Bartel, D.P. (2015). Predicting effective microRNA target sites in mammalian mRNAs. eLife, 4.","DOI":"10.7554\/eLife.05005"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/MED.0000000000000043","article-title":"The nonhuman primate as a model for type 2 diabetes","volume":"21","author":"Pound","year":"2014","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/0471142735.im1214s102","article-title":"Nonhuman primate models for HIV\/AIDS vaccine development","volume":"102","author":"Sui","year":"2013","journal-title":"Curr. Protoc. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuropharm.2014.01.031","article-title":"Serotonergic pharmacology in animal models: From behavioral disorders to dyskinesia","volume":"81","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.chom.2015.01.015","article-title":"Biogeography of the intestinal mucosal and luminal microbiome in the rhesus macaque","volume":"17","author":"Yasuda","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1128\/JCM.43.2.641-649.2005","article-title":"Characterization of cytolethal distending toxin of Campylobacter species isolated from captive macaque monkeys","volume":"43","author":"Dassanayake","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/ar.22727","article-title":"Idiopathic microscopic colitis of rhesus macaques: Quantitative assessment of colonic mucosa","volume":"296","author":"Ardeshir","year":"2013","journal-title":"Anat. Rec."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/030098588201907s04","article-title":"Infection of the colon of the rhesus monkey by spiral-shaped organisms","volume":"7","author":"Zeller","year":"1982","journal-title":"Vet. Pathol. Suppl."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-020711-074937","article-title":"The microbiome in infectious disease and inflammation","volume":"30","author":"Honda","year":"2012","journal-title":"Ann. Rev. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1053\/j.gastro.2016.06.041","article-title":"Duodenal bacteria from patients with celiac disease and healthy subjects distinctly affect gluten breakdown and immunogenicity","volume":"151","author":"Caminero","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2741\/e373","article-title":"Antibacterial agents from actinomycetes\u2014A Review","volume":"4","author":"Mahajan","year":"2012","journal-title":"Front. Biosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10803-007-0480-3","article-title":"Autism and coeliac disease","volume":"38","author":"Barcia","year":"2008","journal-title":"J. Autism Dev. Disord."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.cell.2013.11.035","article-title":"Toward effective probiotics for Autism and other neurodevelopmental disorders","volume":"155","author":"Gilbert","year":"2013","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut microbiota are related to Parkinson\u2019s disease and clinical phenotype","volume":"30","author":"Scheperjans","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Kang, D.W., Park, J.G., Ilhan, Z.E., Wallstrom, G., LaBaer, J., Adams, J.B., and Krajmalnik-Brown, R. (2013). Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068322"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Sestak, K., Conroy, L., Aye, P.P., Mehra, S., Doxiadis, G.G., and Kaushal, D. (2011). Improved xenobiotic metabolism and reduced susceptibility to cancer in gluten-sensitive macaques upon introduction of a gluten-free diet. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018648"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/j.gastro.2011.07.005","article-title":"MicroRNA regulation of intestinal epithelial tight junction permeability","volume":"141","author":"Ye","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/ajg.2014.355","article-title":"Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet","volume":"109","author":"Wacklin","year":"2014","journal-title":"Am. J. Gastroenterol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/11\/684\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:34:14Z","timestamp":1760211254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/8\/11\/684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,28]]},"references-count":84,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11]]}},"alternative-id":["nu8110684"],"URL":"https:\/\/doi.org\/10.3390\/nu8110684","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,28]]}}}