{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:02:48Z","timestamp":1775559768519,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Kamprad family foundation for entrepreneurship, research and charity"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Controversy pervades the definition of adequate and optimal vitamin D status. The Institutes of Medicine have recommended serum 25(OH)D levels above 50 nmol\/L based upon evidence related to bone health, but some experts, including the Endocrine Society and International Osteoporosis Foundation, suggest a minimum serum 25(OH)D level of 75 nmol\/L to reduce the risk of falls and fractures in older adults. In a cross-sectional study, we compared vitamin D status in people \u226575 years selected from four groups with a frailty phenotype, combined with a control group free from serious illness, and who considered themselves completely healthy. Only 13% of the 169 controls were vitamin D deficient (S-25(OH)D) &lt; 50 nmol\/L), in contrast with 49% of orthopedic patients with hip fractures (n = 133), 31% of stroke patients (n = 122), 39% of patients visiting the hospital\u2019s emergency department \u22654 times a year (n = 81), and 75% of homebound adult residents in long-term care nursing homes (n = 51). The mean vitamin D concentration of the healthy control group (74 nmol\/L) was similar to a suggested optimal level based on physiological data and mortality studies, and much higher than that of many officially recommended cut-off levels for vitamin D deficiency (&lt;50 nmol\/L). The present study provides a basis for planning and implementing public guidelines for the screening of vitamin D deficiency and vitamin D treatment for frail elderly patients.<\/jats:p>","DOI":"10.3390\/nu8110717","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T10:05:56Z","timestamp":1478858756000},"page":"717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Older Swedish Adults with High Self-Perceived Health Show Optimal 25-Hydroxyvitamin D Levels Whereas Vitamin D Status Is Low in Patients with High Disease Burden"],"prefix":"10.3390","volume":"8","author":[{"given":"Martin","family":"Carlsson","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, County Hospital of Kalmar, 391 85 Kalmar, Sweden"},{"name":"Department of Medicine and Optometry, Linnaeus University, 392 34 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Wanby","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Internal Medicine, County Hospital of Kalmar, 391 85 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Brudin","sequence":"additional","affiliation":[{"name":"Department Medical and Health Sciences, University of Linkoping, 581 83 Link\u00f6ping, Sweden"},{"name":"Department of Clinical Physiology, County Hospital, 391 85 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Lexne","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, County Hospital of Kalmar, 391 85 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Mathold","sequence":"additional","affiliation":[{"name":"Department Geriatric Medicine, County Hospital of Kalmar, 391 85 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Nobin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, County Hospital of Kalmar, 391 85 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Ericson","sequence":"additional","affiliation":[{"name":"Department of Medicine and Optometry, Linnaeus University, 392 34 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Nordqvist","sequence":"additional","affiliation":[{"name":"The Pharmaceutical Department, Kalmar County Council, 392 44 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Medicine and Optometry, Linnaeus University, 392 34 Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/edrv.22.4.0437","article-title":"Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications","volume":"22","author":"Lips","year":"2001","journal-title":"Endocr. 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