{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:33:01Z","timestamp":1782300781017,"version":"3.54.5"},"reference-count":42,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006626","name":"Wageningen UR","doi-asserted-by":"publisher","award":["IPOP Customized Nutrition"],"award-info":[{"award-number":["IPOP Customized Nutrition"]}],"id":[{"id":"10.13039\/501100006626","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Controlled studies on the effect of exercise on intestinal uptake of protein are scarce and underlying mechanisms largely unclear. We studied the uptake of the major allergen Ara h 6 following peanut consumption in an exercise model and compared this with changes in markers of intestinal permeability and integrity. Ten overnight-fasted healthy non-allergic men (n = 4) and women (n = 6) (23 \u00b1 4 years) ingested 100 g of peanuts together with a lactulose\/rhamnose (L\/R) solution, followed by rest or by 60 min cycling at 70% of their maximal workload. Significantly higher, though variable, levels of Ara h 6 in serum were found during exercise compared to rest (Peak p = 0.03; area under the curve p = 0.006), with individual fold changes ranging from no increase to an increase of over 150-fold in the uptake of Ara h 6. Similarly, uptake of lactulose (2\u201318 fold change, p = 0.0009) and L\/R ratios (0.4\u20137.9 fold change, p = 0.04) were significantly increased which indicates an increase in intestinal permeability. Intestinal permeability and uptake of Ara h 6 were strongly correlated (r = 0.77, p &lt; 0.0001 for lactulose and Ara h 6). Endurance exercise after consumption may lead to increased paracellular intestinal uptake of food proteins.<\/jats:p>","DOI":"10.3390\/nu9010084","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T10:40:33Z","timestamp":1485168033000},"page":"84","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-9776","authenticated-orcid":false,"given":"Lonneke","family":"JanssenDuijghuijsen","sequence":"first","affiliation":[{"name":"Wageningen Food and Biobased Research, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"},{"name":"Nutrition and Pharmacology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"},{"name":"Human and Animal Physiology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-9455","authenticated-orcid":false,"given":"Klaske","family":"Van Norren","sequence":"additional","affiliation":[{"name":"Nutrition and Pharmacology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"},{"name":"Nutricia Research, P.O. Box 80141, 3508 TC Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Grefte","sequence":"additional","affiliation":[{"name":"Human and Animal Physiology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stef","family":"Koppelman","sequence":"additional","affiliation":[{"name":"Food Allergy Research and Resource Program, Food Science and Technology, University of Nebraska-Lincoln, Rm 279 Food Innovation Center, P.O. Box 886207, Lincoln, NE 68588-6207, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaatje","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre, Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, P.O. Box 616, 6200 MD Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-7491","authenticated-orcid":false,"given":"Jaap","family":"Keijer","sequence":"additional","affiliation":[{"name":"Human and Animal Physiology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-8261","authenticated-orcid":false,"given":"Renger","family":"Witkamp","sequence":"additional","affiliation":[{"name":"Nutrition and Pharmacology, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Wichers","sequence":"additional","affiliation":[{"name":"Wageningen Food and Biobased Research, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,1,21]]},"reference":[{"key":"ref_1","unstructured":"Robinson, T., and Pozzi, F. Mapping Supply And Demand For Animal-Source Foods To 2030. 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