{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:53:21Z","timestamp":1790502801727,"version":"4.1.0"},"reference-count":155,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy","award":["BFU2014-52299-P"],"award-info":[{"award-number":["BFU2014-52299-P"]}]},{"name":"ISCIII-TERCEL","award":["ISCIII-RD12\/0019-0022"],"award-info":[{"award-number":["ISCIII-RD12\/0019-0022"]}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P11-CTS-07564"],"award-info":[{"award-number":["P11-CTS-07564"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial\/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA\/RAR\u03b1 signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A\/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system.<\/jats:p>","DOI":"10.3390\/nu9020159","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T11:07:24Z","timestamp":1487588844000},"page":"159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Role of Vitamin A\/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis"],"prefix":"10.3390","volume":"9","author":[{"given":"Ana","family":"Ca\u00f1ete","sequence":"first","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Malaga, Campus de Teatinos s\/n Malaga 29071, Spain and Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Severo Ochoa 25, Campanillas 29590, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cano","sequence":"additional","affiliation":[{"name":"Max-Delbruck Center for Molecular Medicine, Robert Roessle-Strasse 10, 13125 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-6802","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Mu\u00f1oz-Ch\u00e1puli","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Malaga, Campus de Teatinos s\/n Malaga 29071, Spain and Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Severo Ochoa 25, Campanillas 29590, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Carmona","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Malaga, Campus de Teatinos s\/n Malaga 29071, Spain and Andalusian Center for Nanomedicine and Biotechnology (BIONAND), Severo Ochoa 25, Campanillas 29590, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"ref_1","first-page":"10","article-title":"The discovery of the vitamins","volume":"823","author":"Semba","year":"2012","journal-title":"Int. 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