{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:02:09Z","timestamp":1790550129980,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cobalamin deficiency is common in patients with Crohn\u2019s disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency and in long-term maintenance in patients with Crohn\u2019s disease. We performed a multicenter retrospective cohort study that included 94 patients with Crohn\u2019s disease and cobalamin deficiency. Seventy-six patients had B12 deficiency and 94.7% of them normalized their cobalamin levels with oral treatment. The most used dose was 1 mg\/day, but there were no significant differences in treatment effectiveness depending on the dose used (\u22651 mg\/24 h vs. &lt;1 mg\/24 h). Eighty-two patients had previous documented B12 deficiency and were treated with oral B12 to maintain their correct cobalamin levels. After a mean follow-up of 3 years, the oral route was effective as maintenance treatment in 81.7% of patients. A lack of treatment adherence was admitted by 46.6% of patients in who the oral route failed. In conclusion, our study shows that oral cyanocobalamin provides effective acute and maintenance treatment for vitamin B12 deficiency caused by CD with or without ileum resection.<\/jats:p>","DOI":"10.3390\/nu9030308","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T11:39:09Z","timestamp":1490009949000},"page":"308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Oral Cyanocobalamin is Effective in the Treatment of Vitamin B12 Deficiency in Crohn\u2019s Disease"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-3529","authenticated-orcid":false,"given":"Fernando","family":"Gomoll\u00f3n","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico Universitario \u201cLozano Blesa\u201d, Avenue San Juan Bosco, 15, Zaragoza 50009, Arag\u00f3n, Spain"},{"name":"Arag\u00f3n Health Research Institute (IIS Arag\u00f3n), Zaragoza 50009, Arag\u00f3n, Spain"},{"name":"University of Zaragoza, Zaragoza 50009, Arag\u00f3n, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red, Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Madrid 28029, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Gargallo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario \u201cLozano Blesa\u201d, Avenue San Juan Bosco, 15, Zaragoza 50009, Arag\u00f3n, Spain"},{"name":"Arag\u00f3n Health Research Institute (IIS Arag\u00f3n), Zaragoza 50009, Arag\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Salamanca, Salamanca 37007, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Vicente","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, Zaragoza 50009, Arag\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-6038","authenticated-orcid":false,"given":"Alberto","family":"Lue","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario \u201cLozano Blesa\u201d, Avenue San Juan Bosco, 15, Zaragoza 50009, Arag\u00f3n, Spain"},{"name":"Arag\u00f3n Health Research Institute (IIS Arag\u00f3n), Zaragoza 50009, Arag\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mir","sequence":"additional","affiliation":[{"name":"Hospital Ernest Lluch Martin, Calatayud, Zaragoza 50299, Arag\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garc\u00eda-Alvarado","sequence":"additional","affiliation":[{"name":"Hospital Virgen de la Concha, Zamora 49022, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gracia","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, Zaragoza 50009, Arag\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Garc\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Miguel Servet, Zaragoza 50009, Arag\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1056\/NEJMcp1113996","article-title":"Vitamin B12 deficiency","volume":"368","author":"Stabler","year":"2013","journal-title":"N. 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