{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:05:24Z","timestamp":1791943524623,"version":"4.3.4"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["HI15C3207"],"award-info":[{"award-number":["HI15C3207"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Protein-energy wasting (PEW) is associated with mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis. The correct diagnosis of PEW is extremely important in order to predict clinical outcomes. However, it is unclear which parameters should be used to diagnose PEW. Therefore, this retrospective observational study investigated the relationship between mortality and nutritional parameters in ESRD patients on maintenance hemodialysis. A total of 144 patients were enrolled. Nutritional parameters, including body mass index, serum albumin, dietary intake, normalized protein catabolic rate (nPCR), and malnutrition inflammation score (MIS), were measured at baseline. Fifty-three patients died during the study. Survivors had significantly higher nPCR (1.10 \u00b1 0.24 g\/kg\/day vs. 1.01 \u00b1 0.21 g\/kg\/day; p = 0.048), energy intake (26.7 \u00b1 5.8 kcal\/kg vs. 24.3 \u00b1 4.2 kcal\/kg; p = 0.009) and protein intake (0.91 \u00b1 0.21 g\/kg vs. 0.82 \u00b1 0.24 g\/kg; p = 0.020), and lower MIS (5.2 \u00b1 2.3 vs. 6.1 \u00b1 2.1, p = 0.039). In multivariable analysis, energy intake &lt;25 kcal\/kg (HR 1.860, 95% CI 1.018\u20133.399; p = 0.044) and MIS &gt; 5 (HR 2.146, 95% CI 1.173\u20133.928; p = 0.013) were independent variables associated with all-cause mortality. These results suggest that higher MIS and lower energy intake are harmful to ESRD patients on maintenance hemodialysis. Optimal energy intake could reduce mortality in these patients.<\/jats:p>","DOI":"10.3390\/nu9040399","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T11:22:04Z","timestamp":1492514524000},"page":"399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Nutritional Status Predicts 10-Year Mortality in Patients with End-Stage Renal Disease on Hemodialysis"],"prefix":"10.3390","volume":"9","author":[{"given":"Shin","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Dietetics and Nutrition Service, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5110-5716","authenticated-orcid":false,"given":"Yongsoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/ndt\/gfn167","article-title":"Excess mortality due to interaction between protein-energy wasting, inflammation and cardiovascular disease in chronic dialysis patients","volume":"23","author":"Grootendorst","year":"2008","journal-title":"Nephrol. 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