{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:35:13Z","timestamp":1778636113227,"version":"3.51.4"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study investigated the influence of intravenous arginine (Arg) administration on alteration of circulating proangiogenic cells and remote lung injury in a model of polymicrobial sepsis. Mice were assigned to one normal control group (NC) and two sepsis groups that were induced by cecal ligation and puncture (CLP). One of the sepsis groups was injected with saline (SS), whereas the other (SA) was administered with a single bolus of 300 mg Arg\/kg body weight via the tail vein 1 h after CLP. Septic mice were sacrificed at either 24 or 48 h after CLP, with their blood and lung tissues collected for analysis. Results showed that septic groups had higher proangiogenic cells releasing factors and proangiogenic cells percentage in blood. Also, concentration of inflammatory cytokines and expression of angiopoietin (Angpt)\/Tie-2 genes in lung tissues were upregulated. Arg administration promoted mobilization of circulating proangiogenic cells while it downregulated the production of inflammatory cytokines and expression of Angpt\/Tie-2 genes in the lung. The results of this investigation suggested that intravenous administration of Arg shortly after the onset of sepsis enhanced the mobilization of circulating proangiogenic cells, maintained the homeostasis of the Angpt\/Tie-2 axis, and attenuated remote organ injury in polymicrobial sepsis.<\/jats:p>","DOI":"10.3390\/nu9050507","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T11:13:17Z","timestamp":1495019597000},"page":"507","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intravenous Arginine Administration Promotes Proangiogenic Cells Mobilization and Attenuates Lung Injury in Mice with Polymicrobial Sepsis"],"prefix":"10.3390","volume":"9","author":[{"given":"Chiu-Li","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health Sciences, Chinese Culture University, Taipei 11114, Taiwan"},{"name":"School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-Hui","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Ming","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cathay General Hospital, Taipei 11073, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juey-Ming","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cathay General Hospital, Taipei 11073, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Ling","family":"Yeh","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MCC.0b013e328344b446","article-title":"Multiple organ failure in sepsis: Prognosis and role of systemic inflammatory response","volume":"17","author":"Gustot","year":"2011","journal-title":"Curr. 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