{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:31:08Z","timestamp":1771381868776,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Science, ICT &amp; Future Planning","award":["E0164503-01"],"award-info":[{"award-number":["E0164503-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Natural sleep aids are becoming more popular due to the widespread occurrence of sleep disorders. The objective of this study was to assess the sleep-promoting effects of rice bran\u2014a product that is considered as a functional ingredient. To evaluate the sleep-promoting effects of a standardized rice bran supplement (RBS), we employed a pentobarbital-induced sleep test and conducted analyses of sleep architecture. In addition, the effect of RBS on a caffeine-induced sleep disturbance was investigated. Oral administration of RBS (500 and 1000 mg\/kg) produced a significant decrease in sleep latency and increase in sleep duration in pentobarbital-induced sleep in mice. Moreover, both RBS (1000 mg\/kg) and doxepin hydrochloride (histamine H1 receptor antagonist, 30 mg\/kg) counteracted a caffeine-induced sleep disturbance in mice. In terms of sleep phases, RBS (500 mg\/kg) promoted non-rapid eye movement sleep for the first 3 h following its administration. Lastly, we unveiled a possible mechanism for RBS action as the hypnotic effect of RBS was blocked by a histamine H1 receptor agonist. The present study revealed sleep-promoting effects of RBS using various animal assays. Such effects seem to be mediated through the histaminergic system. Our findings suggest that RBS may be a promising natural aid for relieving sleep problems.<\/jats:p>","DOI":"10.3390\/nu9050512","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T01:47:33Z","timestamp":1495504053000},"page":"512","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sleep-Promoting Effects and Possible Mechanisms of Action Associated with a Standardized Rice Bran Supplement"],"prefix":"10.3390","volume":"9","author":[{"given":"Hyejin","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minseok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Um","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaekwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-6977","authenticated-orcid":false,"given":"Yun-Tai","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangoh","family":"Kwon","sequence":"additional","affiliation":[{"name":"S&amp;D Research and Development Institute, Osong 28156, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boknam","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of tourism Food Service Cuisine, Hallym Polytechinic University, Chuncheon 24210, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suengmok","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nrn2521","article-title":"Sleep as a fundamental property of neuronal assemblies","volume":"9","author":"Krueger","year":"2008","journal-title":"Nat. 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