{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:01:35Z","timestamp":1785200495450,"version":"3.55.0"},"reference-count":59,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,3]],"date-time":"2017-06-03T00:00:00Z","timestamp":1496448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["PhD grant"],"award-info":[{"award-number":["PhD grant"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco (FACEPE)","award":["PRONEM 0741.106-14"],"award-info":[{"award-number":["PRONEM 0741.106-14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A particularly phenolic-rich fraction extracted from red wine from the S\u00e3o Francisco valley (Northeastern Brazil) was chemically characterized and its hypotensive and antioxidant effects on spontaneously hypertensive rats were studied both in vitro and in vivo. The liquid-liquid pH dependent fractionation scheme afforded a fraction with high content of bioactive phenolics such as flavonols, flavonol glycosides, phenolic acids and anthocyanins, whose identities were confirmed by liquid chromatography coupled to mass spectrometry analysis. Pretreatment of spontaneously hypertensive rats with this wine fraction at doses of 50 and 100 mg\/kg by gavage. for 15 days was able to decrease mean arterial pressure and heart rate as well as decrease serum lipid peroxidation. The fraction at concentrations of 0.01\u20131000 \u00b5g\/mL induced concentration-dependent relaxation of isolated rat superior mesenteric artery rings pre-contracted with phenylephrine and this effect was not attenuated by endothelium removal. Our results demonstrate it is possible for phenolic constituents of red wine that are orally bioavailable to exert in vivo hypotensive and antioxidant effects on intact endothelial function.<\/jats:p>","DOI":"10.3390\/nu9060574","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T10:53:09Z","timestamp":1496746389000},"page":"574","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Antioxidant and Antihypertensive Effects of a Chemically Defined Fraction of Syrah Red Wine on Spontaneously Hypertensive Rats"],"prefix":"10.3390","volume":"9","author":[{"given":"Eug\u00eania Abrantes de","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Centro de Biotecnologia, Programa de P\u00f3s Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Campus I, Jo\u00e3o Pessoa, PB 58051-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiane Ferraz Bandeira","family":"Alves","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia, Programa de P\u00f3s Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Campus I, Jo\u00e3o Pessoa, PB 58051-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-8053","authenticated-orcid":false,"given":"Matheus Morais de Oliveira","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia, Programa de P\u00f3s Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Campus I, Jo\u00e3o Pessoa, PB 58051-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clenia de Oliveira","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia, Programa de P\u00f3s Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Campus I, Jo\u00e3o Pessoa, PB 58051-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Maria Sarmento da","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Laborat\u00f3rio de Bioprospec\u00e7\u00e3o Fitoqu\u00edmica, Universidade Federal Rural de Pernambuco, Recife, PE 52171-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Telma Maria Guedes da","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Laborat\u00f3rio de Bioprospec\u00e7\u00e3o Fitoqu\u00edmica, Universidade Federal Rural de Pernambuco, Recife, PE 52171-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir de Andrade","family":"Braga","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia, Programa de P\u00f3s Gradua\u00e7\u00e3o em Produtos Naturais e Sint\u00e9ticos Bioativos, Campus I, Jo\u00e3o Pessoa, PB 58051-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo de Jesus","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia, Universidade Federal dos Vales do Jequitinhonha e Mucur\u00ed, Diamantina, MG, 39100-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223S","DOI":"10.1093\/ajcn\/81.1.223S","article-title":"Polyphenols in foods are more complex than often thought","volume":"81","author":"Cheynier","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2005.04.044","article-title":"Relationship between vasodilation capacity and phenolic content of Spanish wines","volume":"517","author":"Padilla","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.foodchem.2014.03.109","article-title":"Phenolic compounds, organic acids and antioxidant activity of grape juices produced from new Brazilian varieties planted in the northeast region of Brazil","volume":"161","author":"Lima","year":"2014","journal-title":"Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jfca.2009.08.004","article-title":"Antioxidant activity and phenolics content of selected Brazilian wines","volume":"23","author":"Lucena","year":"2010","journal-title":"J. Food Comp. Anal."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.autneu.2010.07.025","article-title":"Acute superoxide scavenging restores depressed baroreflex sensitivity in renovascular hypertensive rats","volume":"159","author":"Pina","year":"2011","journal-title":"Auton. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1590\/S0100-879X2011007500088","article-title":"Angiotensin-ii-induced reactive oxygen species along the sfo-pvn-rvlm pathway: Implications in neurogenic hypertension","volume":"44","author":"Braga","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/bph.13511","article-title":"Nitric oxide generation by the organic nitrate ndbp attenuates oxidative stress and angiotensin ii-mediated hypertension: Organic nitrate and hypertension","volume":"173","author":"Porpino","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/CIRCRESAHA.110.224873","article-title":"Inflammation and neurogenic hypertension: A new role for the circumventricular organs?","volume":"107","author":"Lazartigues","year":"2010","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.jhh.1001034","article-title":"Decreased endogenous antioxidant enzymatic status in essential hypertension","volume":"14","author":"Covas","year":"2000","journal-title":"J. Hum. Hypertens."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/01.HYP.34.4.943","article-title":"Role of angiotensin and oxidative stress in essential hypertension","volume":"34","author":"Romero","year":"1999","journal-title":"Hypertension"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/01.RES.0000135483.12297.e4","article-title":"Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system","volume":"95","author":"Zimmerman","year":"2004","journal-title":"Circ. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.2337\/dc08-s247","article-title":"Nadph oxidases, reactive oxygen species, and hypertension: Clinical implications and therapeutic possibilities","volume":"31","author":"Paravicini","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/B:MCBI.0000049146.89059.53","article-title":"Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension","volume":"266","author":"Dhawan","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"317S","DOI":"10.1093\/ajcn\/81.1.317S","article-title":"Polyphenols and disease risk in epidemiologic studies","volume":"81","author":"Arts","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/2040622311430006","article-title":"Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: An update for clinicians","volume":"3","author":"Habauzit","year":"2012","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Grosso, G., Stepaniak, U., Micek, A., Stefler, D., Bobak, M., and Pajak, A. (2016). Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the hapiee study. Eur. J. Nutr.","DOI":"10.1007\/s00394-016-1187-z"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.numecd.2009.10.019","article-title":"Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk","volume":"21","author":"Covas","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Miranda, A.M., Steluti, J., Fisberg, R.M., and Marchioni, D.M. (2016). Association between polyphenol intake and hypertension in adults and older adults: A population-based study in Brazil. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165791"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3945\/ajcn.110.006783","article-title":"Habitual intake of flavonoid subclasses and incident hypertension in adults","volume":"93","author":"Cassidy","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3945\/ajcn.115.109249","article-title":"Flavonoid intake and incident hypertension in women","volume":"103","author":"Lajous","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1161\/01.CIR.103.23.2792","article-title":"Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release","volume":"103","author":"Freedman","year":"2001","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1016\/j.clnesp.2015.08.001","article-title":"Cardiovascular risk and benefits from antioxidant dietary intervention with red wine in asymptomatic hypercholesterolemics","volume":"10","author":"Apostolidou","year":"2015","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/FJC.0b013e318217db1f","article-title":"Uncovering the vasorelaxant effect induced by vale do s\u00e3o francisco red wine: A role for nitric oxide","volume":"57","author":"Luciano","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1021\/jf970486b","article-title":"Antioxidant activity of different phenolic fractions separated from an Italian red wine","volume":"46","author":"Ghiselli","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","unstructured":"Wrolstad, R.E., Acree, T.E., Decker, E.A., Penner, M.H., Reid, D.S., Schwartz, S.J., Shoemaker, C.F., Smith, D., and Sporns, P. (2003). Determination of total phenolics. Current Protocols in Food Analytical Chemistry, John Wiley & Sons, Inc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S0100-40422009000200026","article-title":"Fenilpropan\u00f3ides e outros constituintes bioativos de nectandra megapotamica","volume":"32","author":"Garcez","year":"2009","journal-title":"Qu\u00edm. Nova"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved abts radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.autneu.2009.12.007","article-title":"Dietary salt enhances angiotensin-ii-induced superoxide formation in the rostral ventrolateral medulla","volume":"155","author":"Braga","year":"2010","journal-title":"Auton. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12997","DOI":"10.3390\/molecules171112997","article-title":"Quercetin improves baroreflex sensitivity in spontaneously hypertensive rats","volume":"17","author":"Monteiro","year":"2012","journal-title":"Molecules"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2298\/JSC130511089M","article-title":"Phenolic composition and free radical scavenging activity of wine produced from Serbian autochtonous grape variety prokupac: A model approach","volume":"79","author":"Menkovic","year":"2014","journal-title":"J. Serb. Chem. Soc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1590\/S0006-87052011005000004","article-title":"Rela\u00e7\u00f5es h\u00eddricas, rendimento e compostos fen\u00f3licos de uvas cabernet sauvignon em tr\u00eas tipos de solo","volume":"70","author":"Chavarria","year":"2011","journal-title":"Bragantia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.17660\/ActaHortic.2005.689.34","article-title":"Water stress increased polyphenolic quality in \u2018merlot\u2019 grapes","volume":"689","author":"Peterlunger","year":"2005","journal-title":"Acta Hortic."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aca.2004.02.028","article-title":"Antioxidant activity of wines and relation with their polyphenolic composition","volume":"513","author":"Troncoso","year":"2004","journal-title":"Anal. Chim. Acta"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11130-013-0351-3","article-title":"The content of phenolic compounds and radical scavenging activity varies with carrot origin and root color","volume":"68","author":"Leja","year":"2013","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jff.2015.10.034","article-title":"In vivo antioxidant activity of grape, pomace and wine from three red varieties grown in Argentina: Its relationship to phenolic profile","volume":"20","author":"Lingua","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1021\/jf9801973","article-title":"Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products","volume":"46","author":"Velioglu","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1042\/bst0240790","article-title":"Antioxidant activities of flavonoids as bioactive components of food","volume":"24","author":"Miller","year":"1996","journal-title":"Biochem. Soc. Trans."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s12161-012-9507-2","article-title":"Determination of quercetin, gallic acid, resveratrol, catechin and malvidin in Brazilian wines elaborated in the vale do s\u00e3o francisco using liquid\u2013liquid extraction assisted by ultrasound and GC-MS","volume":"6","author":"Silva","year":"2013","journal-title":"Food Anal. Method"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Dias, F.d.S., David, J.M., and David, J.P. (2015). Determination of phenolic acids and quercetin in brazilian red wines from vale do s\u00e3o francisco region using liquid-liquid ultrasound-assisted extraction and HPLC-DAD-MS. J. Braz. Chem. Soc., 27.","DOI":"10.5935\/0103-5053.20150363"},{"key":"ref_42","first-page":"99","article-title":"Phenolic compounds of wines from georgian autochthonous grapes, rkatsiteli and saperavi, prepared by georgian (kakhetian) technology","volume":"6","author":"Shalashvili","year":"2012","journal-title":"ResearchGate"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5344\/ajev.1998.49.2.142","article-title":"Quercetin and p-coumaric acid concentrations in commercial wines","volume":"49","author":"Goldberg","year":"1998","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5344\/ajev.1995.46.2.187","article-title":"Cluster sun exposure and quercetin in pinot noir grapes and wine","volume":"46","author":"Price","year":"1995","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1021\/jf034149g","article-title":"Direct HPLC analysis of quercetin and trans-resveratrol in red wine, grape, and winemaking byproducts","volume":"51","author":"Careri","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/jf00050a003","article-title":"Direct HPLC analysis of cis- and trans-resveratrol and piceid isomers in Spanish red vitis vinifera wines","volume":"43","author":"Waterhouse","year":"1995","journal-title":"J. Agric. Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jphotochem.2007.11.011","article-title":"Determination of products derived from trans-resveratrol UV photoisomerisation by means of HPLC\u2013APCI-MS","volume":"196","author":"Montsko","year":"2008","journal-title":"J. Photochem. Photobiol. A"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.3390\/molecules17032773","article-title":"Separation and identification of highly fluorescent compounds derived from trans-resveratrol in the leaves of vitis vinifera infected by plasmopara viticola","volume":"17","year":"2012","journal-title":"Molecules"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1021\/mp7001363","article-title":"Commentary: Bioavailability of flavonoids and polyphenols: Call to arms","volume":"4","author":"Hu","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.etap.2014.07.011","article-title":"Vanillic acid: A potential inhibitor of cardiac and aortic wall remodeling in l-name induced hypertension through upregulation of endothelial nitric oxide synthase","volume":"38","author":"Kumar","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1139\/apnm-2013-0091","article-title":"Oral supplementation with the rutin improves cardiovagal baroreflex sensitivity and vascular reactivity in hypertensive rats","volume":"38","author":"Monteiro","year":"2013","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ejphar.2009.11.006","article-title":"Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats","volume":"627","author":"Romero","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jff.2015.12.032","article-title":"Cardiovascular effects induced by northeastern Brazilian red wine: Role of nitric oxide and redox sensitive pathways","volume":"22","author":"Ribeiro","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s11906-010-0150-2","article-title":"Vascular endothelial function and hypertension: Insights and directions","volume":"12","author":"Dharmashankar","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/01.fjc.0000133060.10597.3c","article-title":"Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine","volume":"44","author":"Miranda","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.HYP.38.2.159","article-title":"Wine polyphenols decrease blood pressure, improve no vasodilatation, and induce gene expression","volume":"38","author":"Diebolt","year":"2001","journal-title":"Hypertension"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ajh.2009.280","article-title":"Vasodilator effects of red wines in subcutaneous small resistance artery of patients with essential hypertension","volume":"23","author":"Porteri","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1254\/jphs.FP0050863","article-title":"The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery","volume":"101","author":"Novakovic","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00005344-200108000-00007","article-title":"Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries","volume":"38","author":"Rendig","year":"2001","journal-title":"J. Cardiovasc. Pharmacol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/6\/574\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:37:54Z","timestamp":1760207874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/6\/574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,3]]},"references-count":59,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6]]}},"alternative-id":["nu9060574"],"URL":"https:\/\/doi.org\/10.3390\/nu9060574","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,3]]}}}