{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:00:28Z","timestamp":1791907228441,"version":"4.3.4"},"reference-count":152,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cardiovascular diseases (CVDs) are leading global health problems. Accumulating epidemiological studies have indicated that consuming fruits was inversely related to the risk of CVDs. Moreover, substantial experimental studies have supported the protective role of fruits against CVDs, and several fruits (grape, blueberry, pomegranate, apple, hawthorn, and avocado) have been widely studied and have shown potent cardiovascular protective action. Fruits can prevent CVDs or facilitate the restoration of morphology and functions of heart and vessels after injury. The involved mechanisms included protecting vascular endothelial function, regulating lipids metabolism, modulating blood pressure, inhibiting platelets function, alleviating ischemia\/reperfusion injury, suppressing thrombosis, reducing oxidative stress, and attenuating inflammation. The present review summarizes recent discoveries about the effects of fruits on CVDs and discusses potential mechanisms of actions based on evidence from epidemiological, experimental, and clinical studies.<\/jats:p>","DOI":"10.3390\/nu9060598","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T03:19:32Z","timestamp":1497410372000},"page":"598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Fruits for Prevention and Treatment of Cardiovascular Diseases"],"prefix":"10.3390","volume":"9","author":[{"given":"Cai-Ning","family":"Zhao","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Meng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-2069","authenticated-orcid":false,"given":"Ya","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-8554","authenticated-orcid":false,"given":"Hua-Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"ref_1","unstructured":"WHO (2017, March 13). Cardiovascular Diseases (CVDs). Available online: http:\/\/www.who.int\/cardiovascular_diseases\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1017\/S0007114515003177","article-title":"Dietary patterns and CVD: A systematic review and meta-analysis of observational studies","volume":"114","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1080\/10408398.2015.1107021","article-title":"A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal?","volume":"57","author":"Grosso","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1056\/NEJMoa1501451","article-title":"Fresh fruit consumption and major cardiovascular disease in China","volume":"374","author":"Du","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10654-015-0050-5","article-title":"Fruit intake and cardiovascular disease mortality in the UK Women\u2019s Cohort Study","volume":"30","author":"Lai","year":"2015","journal-title":"Eur. J. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1017\/S0007114515005231","article-title":"Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women","volume":"115","author":"Hodgson","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2188\/jea.JE20100084","article-title":"Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: The jichi medical school cohort study","volume":"21","author":"Yamada","year":"2011","journal-title":"J. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1056\/NEJMra1203528","article-title":"Behavioral and dietary risk factors for noncommunicable diseases","volume":"369","author":"Ezzati","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.foodres.2013.01.023","article-title":"Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats","volume":"51","author":"Quinones","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1142\/S0192415X09007302","article-title":"A study of the comparative effects of hawthorn fruit compound and simvastatin on lowering blood lipid levels","volume":"37","author":"Xu","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1017\/S0007114511002066","article-title":"Mango modulates body fat and plasma glucose and lipids in mice fed a high-fat diet","volume":"106","author":"Lucas","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1055\/s-0034-1383122","article-title":"Antihypertensive effect of carica papaya via a reduction in ACE activity and improved baroreflex","volume":"80","author":"Brasil","year":"2014","journal-title":"Planta Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.foodchem.2011.04.079","article-title":"Antioxidant capacities and total phenolic contents of 62 fruits","volume":"129","author":"Fu","year":"2011","journal-title":"Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21138","DOI":"10.3390\/molecules201219753","article-title":"Antioxidant phytochemicals for the prevention and treatment of chronic diseases","volume":"20","author":"Zhang","year":"2015","journal-title":"Molecules"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.3390\/ijms11062362","article-title":"Total phenolic contents and antioxidant capacities of selected chinese medicinal plants","volume":"11","author":"Song","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_16","first-page":"2438","article-title":"Antioxidant activity and total phenolic content of medicinal plants associated with prevention and treatment of cardiovascular and cerebrovascular diseases","volume":"4","author":"Gan","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3390\/ijms12042112","article-title":"Total phenolic contents and antioxidant capacities of herbal and tea infusions","volume":"12","author":"Fu","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1039\/c2fo30110e","article-title":"Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi","volume":"3","author":"Guo","year":"2012","journal-title":"Food Funct."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1080\/10408398.2010.529624","article-title":"Phenolic compounds and bioactivities of pigmented rice","volume":"53","author":"Deng","year":"2013","journal-title":"Crit. Rev. Food Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jff.2012.10.015","article-title":"Antioxidant capacities and total phenolic contents of 56 vegetables","volume":"5","author":"Deng","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.indcrop.2013.09.017","article-title":"Antioxidant capacities and total phenolic contents of infusions from 223 medicinal plants","volume":"51","author":"Li","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jff.2013.10.022","article-title":"Total phenolic contents and antioxidant capacities of 51 edible and wild flowers","volume":"6","author":"Li","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Xu, D.P., Li, Y., Meng, X., Zhou, T., Zhou, Y., Zheng, J., Zhang, J.J., and Li, H.B. (2017). Natural antioxidants in foods and medicinal plants: Extraction, assessment and resources. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010096"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.3390\/molecules15128602","article-title":"Antioxidant capacities and total phenolic contents of 56 wild fruits from South China","volume":"15","author":"Fu","year":"2010","journal-title":"Molecules"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4149\/BLL_2012_105","article-title":"Plant polyphenols in prevention of heart disease","volume":"113","author":"Ginter","year":"2012","journal-title":"Bratisl. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.3390\/nu6126020","article-title":"Resources and biological activities of natural polyphenols","volume":"6","author":"Li","year":"2014","journal-title":"Nutrients"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1017\/S0007114513002328","article-title":"Fruit and vegetable intake and risk of CHD: Results from prospective cohort studies of Chinese adults in Shanghai","volume":"111","author":"Yu","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijcard.2015.01.077","article-title":"Consumption of fruit and vegetable and risk of coronary heart disease: A meta-analysis of prospective cohort studies","volume":"183","author":"Gan","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1017\/S0007114510000462","article-title":"Fruit and vegetable intake and risk of acute coronary syndrome","volume":"104","author":"Hansen","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.atherosclerosis.2012.12.022","article-title":"Total and specific fruit and vegetable consumption and risk of stroke: A prospective study","volume":"227","author":"Larsson","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1161\/STROKEAHA.110.611152","article-title":"Colors of fruit and vegetables and 10-year incidence of stroke","volume":"42","author":"Verschuren","year":"2011","journal-title":"Stroke"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ejcn.2011.36","article-title":"Raw and processed fruit and vegetable consumption and 10-year stroke incidence in a population-based cohort study in the Netherlands","volume":"65","author":"Verschuren","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/STROKEAHA.111.637835","article-title":"Dietary flavonoids and risk of stroke in women","volume":"43","author":"Cassidy","year":"2012","journal-title":"Stroke"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.3945\/jn.116.230185","article-title":"Flavanone intake is inversely associated with risk of incident ischemic stroke in the REasons for geographic and racial differences in stroke (REGARDS) study","volume":"146","author":"Goetz","year":"2016","journal-title":"J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0140-6736(90)90944-Z","article-title":"Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context","volume":"335","author":"Collins","year":"1990","journal-title":"Lancet"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ajh.2011.186","article-title":"Fruit and vegetable intake and the risk of hypertension in middle-aged and older women","volume":"25","author":"Wang","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/jhh.2010.48","article-title":"High fruit intake is associated with a lower risk of future hypertension determined by home blood pressure measurement: The Ohasama study","volume":"25","author":"Ohkubo","year":"2011","journal-title":"J. Hum. Hypertens."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/HYPERTENSIONAHA.115.06497","article-title":"Fruit and vegetable consumption and the incidence of hypertension in three prospective cohort studies","volume":"67","author":"Borgi","year":"2016","journal-title":"Hypertension"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ypmed.2014.07.016","article-title":"Gender differences in the relationship between risk of hypertension and fruit intake","volume":"67","author":"Song","year":"2014","journal-title":"Prev. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1464-5491.2012.03764.x","article-title":"Increased dietary fruit intake was associated with lower burden of carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus","volume":"30","author":"Chan","year":"2013","journal-title":"Diabetic Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.jada.2011.07.010","article-title":"Fruit consumption is associated with lower carotid intima-media thickness and C-reactive protein levels in patients with type 2 diabetes mellitus","volume":"111","author":"Zhu","year":"2011","journal-title":"J. Am. Diet Assoc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3945\/ajcn.116.133132","article-title":"Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men","volume":"104","author":"Cassidy","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jand.2013.01.018","article-title":"Estimated daily flavonoid and stilbene intake from fruits, vegetables, and nuts and associations with lipid profiles in chinese adults","volume":"113","author":"Li","year":"2013","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3945\/ajcn.110.000521","article-title":"Fruit, vegetables, and olive oil and risk of coronary heart disease in Italian women: The EPICOR study","volume":"93","author":"Bendinelli","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ejcn.2010.46","article-title":"Association between the frequency of fruit and vegetable consumption and cardiovascular disease in male smokers and non-smokers","volume":"64","author":"Dauchet","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s12603-014-0010-x","article-title":"Fruit and vegetable consumption, ethnicity and risk of fatal ischemic heart disease","volume":"18","author":"Sharma","year":"2014","journal-title":"J. Nutr. Health Aging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.numecd.2013.03.004","article-title":"Adherence to recommendations for fruit and vegetable intake, ethnicity and ischemic heart disease mortality","volume":"23","author":"Sangita","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ejhf.191","article-title":"Fruit and vegetable intake and rate of heart failure: A population-based prospective cohort of women","volume":"17","author":"Rautiainen","year":"2015","journal-title":"Eur. J. Heart Fail."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00004872-200501000-00004","article-title":"Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: A statement by the working group on endothelin and endothelial factors of the European Society of Hypertension","volume":"23","author":"Deanfield","year":"2005","journal-title":"J. Hypertens."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/ajh.2012.98","article-title":"Vascular and cardiac effects of grape powder in the spontaneously hypertensive rat","volume":"25","author":"Thandapilly","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.3892\/mmr.2016.5699","article-title":"Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress","volume":"14","author":"Liang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/ptr.4793","article-title":"Effects of oligomeric grape seed proanthocyanidins on heart, aorta, kidney in DOCA-salt mice: Role of oxidative stress","volume":"27","author":"Wang","year":"2013","journal-title":"Phytother. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.foodchem.2012.05.089","article-title":"Endothelium-dependent vasodilator and antioxidant properties of a novel enzymatic extract of grape pomace from wine industrial waste","volume":"135","author":"Justo","year":"2012","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejpb.2011.09.002","article-title":"Red grape skin and seeds polyphenols: Evidence of their protective effects on endothelial progenitor cells and improvement of their intestinal absorption","volume":"80","author":"Felice","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.jnutbio.2012.09.006","article-title":"Malvidin, a red wine polyphenol, modulates mammalian myocardial and coronary performance and protects the heart against ischemia\/reperfusion injury","volume":"24","author":"Quintieri","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1248\/bpb.b12-00598","article-title":"Grape seed proanthocyanidin extracts enhance endothelial nitric oxide synthase expression through 5\u2032-AMP activated protein kinase\/surtuin 1-krupple like factor 2 pathway and modulate blood pressure in ouabain induced hypertensive rats","volume":"35","author":"Cui","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3892\/ijmm.2015.2246","article-title":"Grape pomace extract exerts antioxidant effects through an increase in GCS levels and GST activity in muscle and endothelial cells","volume":"36","author":"Goutzourelas","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.advms.2014.02.005","article-title":"Does grape seed extract potentiate the inhibition of platelet reactivity in the presence of endothelial cells?","volume":"59","author":"Luzak","year":"2014","journal-title":"Adv. Med. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1089\/jmf.2012.2408","article-title":"Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia","volume":"16","author":"Razavi","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00394-013-0601-z","article-title":"Red grape berry-cultured cells reduce blood pressure in rats with metabolic-like syndrome","volume":"53","author":"Leibowitz","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ijo.2012.75","article-title":"Low doses of grape seed procyanidins reduce adiposity and improve the plasma lipid profile in hamsters","volume":"37","author":"Caimari","year":"2013","journal-title":"Int. J. Obes."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2174\/1874091X01206010078","article-title":"High density lipoprotein and it\u2019s dysfunction","volume":"6","author":"Eren","year":"2012","journal-title":"Open Biochem. J."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zagayko, A.L., Kravchenko, G.B., Krasilnikova, O.A., and Ogai, Y.O. (2013). Grape polyphenols increase the activity of HDL enzymes in old and obese rats. Oxid. Med. Cell. Longev., 593761.","DOI":"10.1155\/2013\/593761"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00394-012-0411-8","article-title":"The polyphenol-rich extracts from black chokeberry and grape seeds impair changes in the platelet adhesion and aggregation induced by a model of hyperhomocysteinemia","volume":"52","author":"Malinowska","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/ijs.12391","article-title":"Protective effect of grape seed and skin extract on cerebral ischemia in rat: Implication of transition metals","volume":"10","author":"Safwen","year":"2015","journal-title":"Int. J. Stroke"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1248\/bpb.33.759","article-title":"The molecular mechanism of protective effects of grape seed proanthocyanidin extract on reperfusion arrhythmias in rats in vivo","volume":"33","author":"Zhao","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jvs.2010.09.017","article-title":"Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis","volume":"53","author":"Zhang","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3109\/09637486.2015.1064870","article-title":"14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model","volume":"66","author":"Stroher","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1017\/S0007114512003911","article-title":"Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats","volume":"109","author":"Ishisaka","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.1021\/jf2025264","article-title":"Phenolic acids are in vivo atheroprotective compounds appearing in the serum of rats after blueberry consumption","volume":"59","author":"Xie","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"14014","DOI":"10.1038\/srep14014","article-title":"Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation","volume":"5","author":"Cao","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.atherosclerosis.2013.02.025","article-title":"The effect of pomegranate extract on coronary artery atherosclerosis in SR-BI\/APOE double knockout mice","volume":"228","author":"Igdoura","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"34246","DOI":"10.1038\/srep34246","article-title":"Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats","volume":"6","author":"Sun","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3923\/pjbs.2014.991.998","article-title":"Motor and cognitive deficits due to permanent cerebral hypoperfusion\/ischemia improve by pomegranate seed extract in rats","volume":"17","author":"Hajipour","year":"2014","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1016\/j.foodchem.2012.07.067","article-title":"Evaluation of cardiovascular protective effect of different apple varieties\u2014Correlation of response with composition","volume":"135","author":"Serra","year":"2012","journal-title":"Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Gonzalez, J., Donoso, W., Sandoval, N., Reyes, M., Gonzalez, P., Gajardo, M., Morales, E., Neira, A., Razmilic, I., and Yuri, J.A. (2015). Apple peel supplemented diet reduces parameters of metabolic syndrome and atherogenic progression in ApoE\u2212\/\u2212 mice. Evid. Based Complement. Altern., 918384.","DOI":"10.1155\/2015\/918384"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/1535370215627032","article-title":"Ethanol extract of Zhongtian hawthorn lowers serum cholesterol in mice by inhibiting transcription of 3-hydroxy-3-methylglutaryl-CoA reductase via nuclear factor-kappa B signal pathway","volume":"241","author":"Hu","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1021\/jf400283w","article-title":"Effects of pectin pentaoligosaccharide from hawthorn (Crataegus pinnatifida Bunge. Var. Major) on the activity and mRNA levels of enzymes involved in fatty acid oxidation in the liver of mice fed a high-fat diet","volume":"61","author":"Li","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5551\/jat.19174","article-title":"Hawthorn fruit attenuates atherosclerosis by improving the hypolipidemic and antioxidant activities in apolipoprotein E-Deficient mice","volume":"21","author":"Zhang","year":"2014","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jep.2013.04.053","article-title":"Effects of an aqueous extract of Crataegus pinnatifida Bge. Var. Major N.E.Br. fruit on experimental atherosclerosis in rats","volume":"148","author":"Zhang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1590\/0103-8478cr20141516","article-title":"Avocado: Characteristics, health benefits and uses","volume":"46","author":"Duarte","year":"2016","journal-title":"Cienc. Rural"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.foodres.2010.11.012","article-title":"Effect of maturity stage on the content of fatty acids and antioxidant activity of \u2018Hass\u2019 avocado","volume":"44","author":"Olivas","year":"2011","journal-title":"Food Res. Int."},{"key":"ref_84","first-page":"193","article-title":"Isolation and chemical identification of lipid derivatives from avocado (Persea americana) pulp with antiplatelet and antithrombotic activities","volume":"6","author":"Rizzo","year":"2015","journal-title":"Food Funct."},{"key":"ref_85","first-page":"386425","article-title":"Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes","volume":"2014","year":"2014","journal-title":"Dis. Markers"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Carvajal-Zarrabal, O., Nolasco-Hipolito, C., Aguilar-Uscanga, M.G., Santiesteban, G.M., Hayward-Jones, P.M., and Barradas-Dermitz, D.M. (2014). Effect of dietary intake of avocado oil and olive oil on biochemical markers of liver function in sucrose-fed rats. Biomed. Res. Int., 595479.","DOI":"10.1155\/2014\/595479"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.2174\/1381612811319340007","article-title":"Avocado (Persea americana) seed as a source of bioactive phytochemicals","volume":"19","author":"Dabas","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/FJC.0000000000000132","article-title":"Cardioprotection afforded by sour cherry seed kernel: The role of heme oxygenase-1","volume":"64","author":"Czompa","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12012-013-9238-7","article-title":"Preventive effect of total flavones of Choerospondias axillaries on ischemia\/reperfusion-induced myocardial infarction-related MAPK signaling pathway","volume":"14","author":"Li","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Zapata-Sudo, G., Da, S.J., Pereira, S.L., Souza, P.J., de Moura, R.S., and Sudo, R.T. (2014). Oral treatment with Euterpe oleracea Mart. (acai) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-227"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.numecd.2010.04.011","article-title":"Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice","volume":"22","author":"Mauray","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1089\/jmf.2010.0181","article-title":"Unrefined and refined black raspberry seed oils significantly lower triglycerides and moderately affect cholesterol metabolism in male Syrian hamsters","volume":"14","author":"Ash","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5582\/bst.2016.01056","article-title":"Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia","volume":"10","author":"Yang","year":"2016","journal-title":"Biosci. Trends"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1021\/jf200193r","article-title":"Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages","volume":"59","author":"Fujiwara","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1080\/14786419.2014.939087","article-title":"Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage","volume":"28","author":"Ono","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/ptr.4949","article-title":"Evaluation of the antihypertensive properties of yellow passion fruit pulp (Passiflora edulis Sims f. Flavicarpa Deg.) in spontaneously hypertensive rats","volume":"28","author":"Konta","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1271\/bbb.120302","article-title":"Antihypertensive effect of boysenberry seed polyphenols on spontaneously hypertensive rats and identification of orally absorbable proanthocyanidins with vasorelaxant activity","volume":"76","author":"Furuuchi","year":"2012","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.nutres.2012.10.001","article-title":"The hypocholesterolemic activity of acai (Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat","volume":"32","author":"Souza","year":"2012","journal-title":"Nutr. Res."},{"key":"ref_99","first-page":"627","article-title":"Evaluation of antioxidant and neuroprotective effect of date palm (Phoenix dactylifera L.) against bilateral common carotid artery occlusion in rats","volume":"49","author":"Pujari","year":"2011","journal-title":"Indian J. Exp. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/jfbc.12226","article-title":"Effects of a natural extract of Aronia melanocarpa berry on endothelial cell nitric oxide production","volume":"40","author":"Varela","year":"2016","journal-title":"J. Food Biochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jnutbio.2014.03.016","article-title":"Effects of Saskatoon berry powder on monocyte adhesion to vascular wall of leptin receptor-deficient diabetic mice","volume":"25","author":"Zhao","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jnutbio.2015.05.015","article-title":"Endoplasmic reticulum stress in diabetic mouse or glycated LDL-treated endothelial cells: Protective effect of Saskatoon berry powder and cyanidin glycans","volume":"26","author":"Zhao","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/MBC.0b013e328343f7da","article-title":"Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables","volume":"22","author":"Guzman","year":"2011","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.foodchem.2013.02.019","article-title":"Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells","volume":"139","author":"Kono","year":"2013","journal-title":"Food Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1021\/acs.jafc.5b00797","article-title":"Manitoba Lingonberry (Vaccinium vitis-idaea) bioactivities in ischemia-reperfusion injury","volume":"63","author":"Isaak","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jnutbio.2013.12.001","article-title":"Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kappa B independent of NRF2-mediated mechanism","volume":"25","author":"Lee","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1039\/C4FO00998C","article-title":"Anti-atherogenic properties of date vs. Pomegranate polyphenols: The benefits of the combination","volume":"6","author":"Rosenblat","year":"2015","journal-title":"Food Funct."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Li, S.H., Zhao, P., Tian, H.B., Chen, L.H., and Cui, L.Q. (2015). Effect of grape polyphenols on blood pressure: A meta-analysis of randomized controlled trials. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137665"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jff.2013.12.017","article-title":"A randomized, double-blind, placebo-controlled, pilot study to evaluate the effect of whole grape extract on antioxidant status and lipid profile","volume":"7","author":"Evans","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1039\/C5FO00100E","article-title":"Comparative effects of red and white grapes on oxidative markers and lipidemic parameters in adult hypercholesterolemic humans","volume":"6","author":"Rahbar","year":"2015","journal-title":"Food Funct."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3109\/09637486.2012.753040","article-title":"LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers","volume":"64","author":"Yubero","year":"2013","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Li, S.H., Tian, H.B., Zhao, H.J., Chen, L.H., and Cui, L.Q. (2013). The acute effects of grape polyphenols supplementation on endothelial function in adults: Meta-Analyses of controlled trials. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069818"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jnutbio.2013.11.002","article-title":"One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans","volume":"25","author":"Giampieri","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3945\/jn.113.188169","article-title":"Freeze-dried strawberries lower serum cholesterol and lipid peroxidation in adults with abdominal adiposity and elevated serum lipids","volume":"144","author":"Basu","year":"2014","journal-title":"J. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.nutres.2010.06.016","article-title":"Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome","volume":"30","author":"Basu","year":"2010","journal-title":"Nutr. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5551\/jat.6114","article-title":"Attenuation of meal-induced inflammatory and thrombotic responses in overweight men and women after 6-week daily strawberry (Fragaria) intake-a randomized placebo-controlled trial","volume":"18","author":"Ellis","year":"2011","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/07315724.2010.10719816","article-title":"Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women","volume":"29","author":"Linares","year":"2010","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1475-2891-10-45","article-title":"Effects of acai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: A pilot study","volume":"10","author":"Udani","year":"2011","journal-title":"Nutr. J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/ptr.5011","article-title":"Improved lipid profile in hyperlipidemic patients taking vaccinium arctostaphylos fruit hydroalcoholic extract: A randomized double-blind placebo-controlled clinical trial","volume":"28","author":"Kianbakht","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3945\/ajcn.113.060590","article-title":"Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: A randomized crossover trial","volume":"98","author":"Larmo","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/ejcn.2010.268","article-title":"Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women","volume":"65","author":"Lehtonen","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3945\/ajcn.2009.27814","article-title":"Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects","volume":"90","author":"Qin","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.jand.2012.05.005","article-title":"Daily apple versus dried plum: Impact on cardiovascular disease risk factors in postmenopausal women","volume":"112","author":"Chai","year":"2012","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1002\/jsfa.8016","article-title":"Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: Results of a randomized clinical trial","volume":"97","author":"Tenore","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00394-012-0489-z","article-title":"Intake of whole apples or clear apple juice has contrasting effects on plasma lipids in healthy volunteers","volume":"52","author":"Dragsted","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2011.09.028","article-title":"Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: A randomized controlled trial","volume":"52","author":"Bondonno","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/mnfr.201200663","article-title":"Bioavailability of epicatechin and effects on nitric oxide metabolites of an apple flavanol-rich extract supplemented beverage compared to a whole apple puree: A randomized, placebo-controlled, crossover trial","volume":"57","author":"Hollands","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1139\/cjpp-2012-0303","article-title":"Kiwifruit: Our daily prescription for health","volume":"91","author":"Stonehouse","year":"2013","journal-title":"Can. J. Physiol. Pharm."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.numecd.2013.06.001","article-title":"Inflammatory status modulates plasma lipid and inflammatory marker responses to kiwifruit consumption in hypercholesterolaemic men","volume":"24","author":"Gammon","year":"2014","journal-title":"Nutr. Metab. Cardiovas."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.nutres.2014.01.005","article-title":"Daily kiwifruit consumption did not improve blood pressure and markers of cardiovascular function in men with hypercholesterolemia","volume":"34","author":"Gammon","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3109\/09637480802063517","article-title":"Effects of kiwifruit consumption on serum lipid profiles and antioxidative status in hyperlipidemic subjects","volume":"60","author":"Chang","year":"2009","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/08037051.2014.976979","article-title":"The effect of kiwifruit consumption on blood pressure in subjects with moderately elevated blood pressure: A randomized, controlled study","volume":"24","author":"Svendsen","year":"2015","journal-title":"Blood Press."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/jhh.2011.116","article-title":"Kiwifruit decreases blood pressure and whole-blood platelet aggregation in male smokers","volume":"27","author":"Karlsen","year":"2013","journal-title":"J. Hum. Hypertens."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jacl.2015.10.011","article-title":"Impact of avocado-enriched diets on plasma lipoproteins: A meta-analysis","volume":"10","author":"Peou","year":"2016","journal-title":"J. Clin. Lipidol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00125-010-1927-1","article-title":"The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes","volume":"54","author":"Jenkins","year":"2011","journal-title":"Diabetologia"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/GME.0000000000000200","article-title":"Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: A randomized, double-blind, placebo-controlled pilot study","volume":"21","author":"Terauchi","year":"2014","journal-title":"Menopause"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1017\/S000711451300161X","article-title":"Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension","volume":"110","author":"Ras","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.amjcard.2012.03.030","article-title":"One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease","volume":"110","author":"Gonzalvez","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10557-012-6427-8","article-title":"Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: A triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease","volume":"27","author":"Gonzalvez","year":"2013","journal-title":"Cardiovasc. Drug Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3945\/jn.110.124701","article-title":"Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome","volume":"140","author":"Basu","year":"2010","journal-title":"J. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jand.2014.11.001","article-title":"Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: A randomized, double-blind, placebo-controlled clinical trial","volume":"115","author":"Johnson","year":"2015","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.nutres.2014.07.002","article-title":"Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females","volume":"34","author":"McAnulty","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00394-012-0402-9","article-title":"Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors","volume":"52","author":"Riso","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000356053","article-title":"Effects of freeze-dried strawberry supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes: A randomized double-blind controlled trial","volume":"63","author":"Moazen","year":"2013","journal-title":"Ann. Nutr. Metab."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3945\/ajcn.115.128728","article-title":"Consumption of a flavonoid-rich acai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men","volume":"104","author":"Alqurashi","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"684","DOI":"10.4103\/1735-1995.166227","article-title":"Effects of blackberry (Morus nigra L.) consumption on serum concentration of lipoproteins, apo A-I, apo B, and high-sensitivity-C-reactive protein and blood pressure in dyslipidemic patients","volume":"20","author":"Aghababaee","year":"2015","journal-title":"J. Res. Med. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jff.2012.08.010","article-title":"Intakes of apples or apple polyphenols decease plasma values for oxidized low-density lipoprotein\/\u03b22-glycoprotein I complex","volume":"5","author":"Zhao","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s00394-014-0670-7","article-title":"Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: A randomized crossover trial","volume":"53","author":"Hidalgo","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/ejcn.2010.135","article-title":"The regular consumption of a polyphenol-rich apple does not influence endothelial function: A randomised double-blind trial in hypercholesterolemic adults","volume":"64","author":"Auclair","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"001355","DOI":"10.1161\/JAHA.114.001355","article-title":"Effect of a moderate fat diet with and without avocados on lipoprotein particle number, size and subclasses in overweight and obese adults: A randomized, controlled trial","volume":"4","author":"Wang","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.metabol.2011.12.004","article-title":"The effects of daily consumption of grapefruit on body weight, lipids, and blood pressure in healthy, overweight adults","volume":"61","author":"Dow","year":"2012","journal-title":"Metabolism"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/gme.0b013e3182733794","article-title":"Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women","volume":"20","author":"Figueroa","year":"2013","journal-title":"Menopause"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/6\/598\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:38:56Z","timestamp":1760207936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/6\/598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,13]]},"references-count":152,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6]]}},"alternative-id":["nu9060598"],"URL":"https:\/\/doi.org\/10.3390\/nu9060598","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,13]]}}}