{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:19:25Z","timestamp":1780478365240,"version":"3.54.1"},"reference-count":68,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T00:00:00Z","timestamp":1497657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity. AIM: To analyze and report the outcome of experimental animal studies on the protective effects of NS\/TQ on chemotherapy-associated kidney complications. Design: Standard systematic review and narrative synthesis. Data Sources: MEDLINE, EMBASE databases were searched for relevant articles published up to March 2017. Additionally, a manual search was performed. Criteria for a study\u2019s inclusion were: conducted in animals, systematic reviews and meta-analysis, containing data on nephroprotective effects of NS\/TQ compared to a placebo or other substance. All strains and genders were included. Results: The database search yielded 71 studies, of which 12 (cisplatin-induced nephrotoxicity 8; methotrexate-induced nephrotoxicity 1; doxorubicin-induced nephrotoxicity 2; ifosfamide-induced nephrotoxicity 1) were included in this review. Conclusions: Experimental animal studies showed the protective effect of NS, or TQ, on chemotherapy-induced nephrotoxicity. These effects are caused by decreasing lipid peroxidation and increasing activity of antioxidant enzymes in renal tissue of chemotherapy-treated animals.<\/jats:p>","DOI":"10.3390\/nu9060625","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T10:29:26Z","timestamp":1497868166000},"page":"625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-3132","authenticated-orcid":false,"given":"Marco","family":"Cascella","sequence":"first","affiliation":[{"name":"Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori\u2014IRCCS\u2013\u201cFondazione G. Pascale\u201d, Via Mariano Semmola, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-5896","authenticated-orcid":false,"given":"Giuseppe","family":"Palma","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Barbieri","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-9675","authenticated-orcid":false,"given":"Sabrina","family":"Bimonte","sequence":"additional","affiliation":[{"name":"Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori\u2014IRCCS\u2013\u201cFondazione G. Pascale\u201d, Via Mariano Semmola, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagoth","family":"Amruthraj","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"},{"name":"Clinical, Experimental and Medical Sciences, Chair of Nephrology, Department of Cardio-Vascular Medicine, University of Study of Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Muzio","sequence":"additional","affiliation":[{"name":"Division of Infantile Neuropsychiatry, UOMI-Maternal and Infant Health, Asl NA 3 SUD, Torre del Greco, Via Marconi, 80059 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitale","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Rea","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Falco","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Luciano","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Arra","sequence":"additional","affiliation":[{"name":"S.S.D. Sperimentazione Animale, Istituto Nazionale Tumori\u2014IRCCS\u2014\u201cFondazione G. Pascale\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori\u2014IRCCS\u2013\u201cFondazione G. Pascale\u201d, Via Mariano Semmola, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/jjco\/hyv035","article-title":"Onco-nephrology: Current concepts and future perspectives","volume":"45","author":"Kitai","year":"2015","journal-title":"Jpn. J. Clin. 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