{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:13:54Z","timestamp":1779383634111,"version":"3.53.1"},"reference-count":97,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Essential amino acids (EAAs) are nutritional substrates that promote body protein synthesis; thus we hypothesised that their supplementation may improve circulating albumin (Alb) and haemoglobin (Hb) in rehabilitative elderly patients following hip fractures (HF). Out of the 145 HF patients originally enrolled in our study, 112 completed the protocol. These subjects were divided into two randomised groups, each containing 56 patients. For a period of two months, one group (age 81.4 \u00b1 8.1 years; male\/female 27\/29) received a placebo, and the other (age 83.1 \u00b1 7.5 years; male\/female 25\/31) received 4 + 4 g\/day oral EAAs. At admission, the prevalence of both hypoAlb (&lt;3.5 g\/dL) and hypoHb (&lt;13 g\/dL male, &lt;12 g\/dL female) was similar in the placebo group (64.3% hypoAlb, 66% hypoHb) and the treated group of patients (73.2% hypoAlb, 67.8% hypoHb). At discharge, however, the prevalence of hypoAlb had reduced more in EAAs than in placebo subjects (31.7% in EAAs vs. 77.8% in placebo; p &lt; 0.001). There was a 34.2% reduction of anaemia in hypoHb in EAA subjects and 18.9% in placebo subjects, but the difference was not statistically significant. Oral supplementation of EAAs improves hypoAlb and, to a lesser extent, Hb in elderly rehabilitative subjects with hip fractures. Anaemia was reduced in more than one third of patients, which, despite not being statistically significant, may be clinically relevant.<\/jats:p>","DOI":"10.3390\/nu9060637","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T02:39:15Z","timestamp":1498099155000},"page":"637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Despite Inflammation, Supplemented Essential Amino Acids May Improve Circulating Levels of Albumin and Haemoglobin in Patients after Hip Fractures"],"prefix":"10.3390","volume":"9","author":[{"given":"Roberto","family":"Aquilani","sequence":"first","affiliation":[{"name":"Dipartimento di Biologia e Biotecnologie Universit\u00e0 degli Studi di Pavia, Via Ferrata, 1. I-27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginetto","family":"Zuccarelli","sequence":"additional","affiliation":[{"name":"Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di Mantenimento, Via Leopardi, 3. I-20090 Vimodrone, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Condino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 degli Studi di Pavia, Viale Taramelli, 14. I-27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Catani","sequence":"additional","affiliation":[{"name":"Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di Mantenimento, Via Leopardi, 3. I-20090 Vimodrone, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Rutili","sequence":"additional","affiliation":[{"name":"Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di Mantenimento, Via Leopardi, 3. I-20090 Vimodrone, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consiglia","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di Mantenimento, Via Leopardi, 3. I-20090 Vimodrone, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pisano","sequence":"additional","affiliation":[{"name":"Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di Mantenimento, Via Leopardi, 3. I-20090 Vimodrone, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Verri","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Biotecnologie Universit\u00e0 degli Studi di Pavia, Via Ferrata, 1. 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Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/gerona\/56.4.M212","article-title":"Nutritional parameters, body composition, and progression of disability in older disabled residents living in nursing homes","volume":"56","author":"Zuliani","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1001\/jama.1994.03520130074036","article-title":"Serum albumin level and physical disability as predictors of mortality in older persons","volume":"272","author":"Corti","year":"1994","journal-title":"JAMA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/0115426505020003314","article-title":"Albumin therapy in clinical practice","volume":"20","author":"Mendez","year":"2005","journal-title":"Nutr. Clin. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0025-6196(12)60437-6","article-title":"The sensitivity and specificity of nutrition-related variables in relationship to the duration of hospital stay and the rate of complications","volume":"59","author":"Anderson","year":"1984","journal-title":"Mayo Clin. Proc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/0002-9149(89)90257-9","article-title":"Increased complications and prolonged hospital stay in elderly cardiac surgical patients with low serum albumin","volume":"63","author":"Rich","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/0895-4356(96)00135-7","article-title":"Use of albumin as a predictor of mortality in community dwelling and institutionalized elderly populations","volume":"49","author":"Sahyoun","year":"1996","journal-title":"J. Clin. Epidemiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF03324703","article-title":"Admission albumin levels and functional outcome of elderly hip fracture patients: Is it that important?","volume":"19","author":"Mizrahi","year":"2007","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/02699052.2013.860470","article-title":"Is stroke rehabilitation a metabolic problem?","volume":"28","author":"Aquilani","year":"2014","journal-title":"Brain Inj."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/gerona\/59.3.M249","article-title":"Hemoglobin levels and skeletal muscle: Results from the In CHIANTI study","volume":"59","author":"Cesari","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0002-9343(03)00263-8","article-title":"Anemia and decline in physical performance among older persons","volume":"115","author":"Penninx","year":"2003","journal-title":"Am. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/gerona\/53A.6.M447","article-title":"Morbidity, comorbidity, and their association with disability among community-dwelling oldest-old in Israel","volume":"53","author":"Fuchs","year":"1998","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1532-5415.2004.52208.x","article-title":"Anemia is associated with disability and decreased physical performance and muscle strength in the elderly","volume":"52","author":"Penninx","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.bjc.6600801","article-title":"Impact of epoetin beta on quality of life in patients with malignant disease","volume":"88","author":"Boogaerts","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1001\/jama.281.18.1714","article-title":"The definition of anemia in older persons","volume":"281","author":"Izaks","year":"1999","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/j.seminhematol.2008.06.003","article-title":"Unexplained anemia in the elderly","volume":"45","author":"Makipour","year":"2008","journal-title":"Semin. Hematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00005131-200201000-00009","article-title":"The relationship between admission hemoglobin level and outcome after hip fracture","volume":"16","author":"Gruson","year":"2002","journal-title":"J. Orthop. Trauma"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005131-200407000-00007","article-title":"The effect of perioperative anemia on clinical and functional outcomes in patients with hip fracture","volume":"18","author":"Halm","year":"2004","journal-title":"J. Orthop. Trauma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/ageing\/afm161","article-title":"Anaemia impedes functional mobility after hip fracture surgery","volume":"37","author":"Foss","year":"2008","journal-title":"Age Ageing"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1191\/0269215506cre987oa","article-title":"Prediction of postoperative morbidity, mortality and rehabilitation in hip fracture patients: The cumulated ambulation score","volume":"20","author":"Foss","year":"2006","journal-title":"Clin. Rehabil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0895-4356(92)90081-W","article-title":"Serum albumin in older persons: Relationship with age and health status","volume":"45","author":"Salive","year":"1992","journal-title":"J. Clin. Epidemiol."},{"key":"ref_23","unstructured":"Adunsky, A., Arad, M., Blumstein, T., Weitzman, A., and Mizrahi, E.H. (2008). Discharge hemoglobin and functional outcome of elderly hip fractured patients undergoing rehabilitation. Eur. J. Phys. Rehabil. Med., 417\u2013422."},{"key":"ref_24","first-page":"576","article-title":"The relation between discharge hemoglobin and outcome after hip fracture","volume":"33","author":"Su","year":"2004","journal-title":"Am. J. Orthop."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1182\/blood-2005-10-4308","article-title":"Impact of anemia on hospitalization and mortality in older adults","volume":"107","author":"Culleton","year":"2006","journal-title":"Blood"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1053\/j.seminhematol.2008.06.001","article-title":"Anemia of aging: The role of chronic inflammation and cancer","volume":"45","author":"Ferrucci","year":"2008","journal-title":"Semin. Hematol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neurobiolaging.2005.02.007","article-title":"Anaemia increases the risk of dementia in cognitively intact elderly","volume":"27","author":"Atti","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1111\/j.1532-5415.2005.00491.x","article-title":"Late-life anemia is associated with increased risk of recurrent falls","volume":"53","author":"Penninx","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2106\/00004623-199274020-00011","article-title":"Protein depletion and metabolic stress in elderly patients who have a fracture of the hip","volume":"74","author":"Patterson","year":"1992","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"212S","DOI":"10.1093\/jn\/136.1.212S","article-title":"The regulation of body and skeletal muscle protein metabolism by hormones and amino acids","volume":"136","author":"Liu","year":"2006","journal-title":"J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/SHK.0000000000000384","article-title":"Hormone and cytokine responses to repeated endotoxin exposures-no evidence of endotoxin tolerance after 5 weeks in humans","volume":"44","author":"Rittig","year":"2015","journal-title":"Shock"},{"key":"ref_32","first-page":"25","article-title":"Comprehensive effects of supplemented essential amino acids in patients with severe COPD and sarcopenia","volume":"73","author":"Aquilani","year":"2010","journal-title":"Monaldi Arch. Chest Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.clnu.2011.04.005","article-title":"Effect of essential amino acid supplementation on quality of life, amino acid profile and strength in institutionalized elderly patients","volume":"30","author":"Rondanelli","year":"2011","journal-title":"Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1053\/j.jrn.2016.01.015","article-title":"Dietary management of incremental transition to dialysis therapy: Once-weekly hemodialysis combined with low-protein diet","volume":"26","author":"Bolasco","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.archger.2010.09.005","article-title":"Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients","volume":"52","author":"Aquilani","year":"2011","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1532-5415.1985.tb02276.x","article-title":"Estimating stature from knee height for persons 60 to 90 years of age","volume":"33","author":"Chumlea","year":"1985","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.ejheart.2008.09.002","article-title":"Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure","volume":"10","author":"Aquilani","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"ref_39","unstructured":"(2014). Quarta Revisione dei livelli di Assunzione di Riferimento di Nutrienti (LARN) e di Energia per la popolazione italiana."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.clnu.2009.05.014","article-title":"Dangers, and benefits of the cytokine mediated response to injury and infection","volume":"28","author":"Soeters","year":"2009","journal-title":"Clin. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1046\/j.1365-2044.1998.00438.x","article-title":"Serum albumin: Touchstone or totem?","volume":"53","author":"Margarson","year":"1998","journal-title":"Anaesthesia"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/hep.1840080234","article-title":"Serum albumin","volume":"8","author":"Rothschild","year":"1988","journal-title":"Hepatology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/ajcn\/64.4.552","article-title":"Serum albumin is associated with skeletal muscle in elderly men and women","volume":"64","author":"Baumgartner","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1136\/bmj.287.6405.1589","article-title":"Benefits of supplementary tube feeding after fractured neck of femur: A randomised controlled trial","volume":"287","author":"Bastow","year":"1983","journal-title":"Br. Med. J. Clin. Res. Ed."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00003086-200012000-00018","article-title":"Erythrocyte transfusion causes immunosuppression after total hip replacement","volume":"381","author":"Kendall","year":"2000","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bpa.2015.11.007","article-title":"Perioperative blood conservation strategies for major spine surgery","volume":"30","author":"Theusinger","year":"2016","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12841","DOI":"10.1074\/jbc.273.21.12841","article-title":"Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha and delta-subunits of eiF2b","volume":"273","author":"Kimball","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/bj3340261","article-title":"Amino acid availability regulates p70S6 kinase and multiple translation factors","volume":"334","author":"Wang","year":"1998","journal-title":"Biochem. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3510001","article-title":"Amino acid regulation of gene expression","volume":"351","author":"Fafournoux","year":"2000","journal-title":"Biochem. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1210\/jc.2008-1564","article-title":"Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women","volume":"94","author":"Dillon","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0002-9610(02)00823-1","article-title":"Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine","volume":"183","author":"May","year":"2002","journal-title":"Am. J. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1158\/0008-5472.277.65.1","article-title":"Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss","volume":"65","author":"Smith","year":"2005","journal-title":"Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/jn\/98.4.395","article-title":"Amino acid regulation of albumin synthesis","volume":"98","author":"Rothschild","year":"1969","journal-title":"J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/0884533611431068","article-title":"Supplementation of essential amino acids may reduce the occurrence of infections in rehabilitation patients with brain injury","volume":"27","author":"Boselli","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.archger.2007.08.014","article-title":"Rehabilitation outcome of hip fracture patients: The importance of a positive albumin gain","volume":"47","author":"Mizrahi","year":"2008","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1562S","DOI":"10.1093\/ajcn\/87.5.1562S","article-title":"Role of dietary protein in the sarcopenia of aging","volume":"87","author":"Short","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/jn\/135.7.1809S","article-title":"Amino acid supplementation for reversing bed rest and steroid myopathies","volume":"135","author":"Wolfe","year":"2005","journal-title":"J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"69E","DOI":"10.1016\/j.amjcard.2008.03.004","article-title":"Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia","volume":"101","author":"Solerte","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1073\/pnas.68.1.72","article-title":"Unexpectedly large size of globin messenger ribonucleic acid","volume":"68","author":"Gaskill","year":"1971","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.clnu.2015.03.021","article-title":"Amino acid supplementation is anabolic during the acute phase of endotoxin-induced inflammation: A human randomized crossover trial","volume":"35","author":"Rittig","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_61","first-page":"544","article-title":"Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit","volume":"15","author":"Hsieh","year":"2006","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1155\/2016\/9318329","article-title":"The hip functional retrieval after elective surgery may be enhanced by supplemented essential amino acids","volume":"2016","author":"Baldissarro","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0148607113478191","article-title":"Efficacy of glutamine in the prevention of acute radiation enteritis: A randomized controlled trial","volume":"38","author":"Cordido","year":"2014","journal-title":"JPEN"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/1097-0142(19900701)66:1<62::AID-CNCR2820660113>3.0.CO;2-E","article-title":"Prophylactic glutamine protects the intestinal mucosa from radiation injury","volume":"66","author":"Klimberg","year":"1990","journal-title":"Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/jsre.1999.5713","article-title":"Glutamine is essential for nitric oxide synthesis by murine macrophages","volume":"86","author":"Bellows","year":"1999","journal-title":"J. Surg. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF02062022","article-title":"Excess glutamine exacerbates trinitrobenzenesulfonic acid-induced colitis in rats","volume":"40","author":"Shinozaki","year":"1997","journal-title":"Dis. Colon Rectum"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2141.2007.06502.x","article-title":"Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers","volume":"136","author":"Ferrucci","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.amjmed.2005.06.039","article-title":"Proinflammatory state and circulating erythropoietin in persons with and without anemia","volume":"118","author":"Ferrucci","year":"2005","journal-title":"Am. J. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/path.2110","article-title":"The endocrine system and ageing","volume":"211","author":"Chahal","year":"2007","journal-title":"J. Pathol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jamda.2007.09.009","article-title":"Outcomes at 12 months in a population of elderly patients discharged from a rehabilitation unit","volume":"9","author":"Bellelli","year":"2008","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0954-6820.1981.tb11542.x","article-title":"Relative reference values for clinical chemical and haematological quantities in \u2018healthy\u2019 elderly people","volume":"209","author":"Dybkaer","year":"1981","journal-title":"Acta Med. Scand."},{"key":"ref_72","first-page":"1565","article-title":"Anemia in the elderly","volume":"62","author":"Smith","year":"2000","journal-title":"Am. Fam. Physician"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1152\/jappl.1993.74.1.186","article-title":"Effects of reduced O2 delivery with anemia, hypoxia, or ischemia on peak VO2 and force in skeletal muscle","volume":"74","author":"Dodd","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.ejcn.1601099","article-title":"Prevalence of anemia in elderly subjects living at home: Role of micronutrient deficiency and inflammation","volume":"54","author":"Olivares","year":"2000","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00005768-200001000-00018","article-title":"Skeletal muscle: Microcirculatory adaptation to metabolic demand","volume":"32","author":"Hepple","year":"2000","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/euhj.1998.1446","article-title":"Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure","volume":"20","author":"Anker","year":"1999","journal-title":"Eur. Heart J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00926829","article-title":"Acute treatment with tumour necrosis factor-alpha induces changes in protein metabolism in rat skeletal muscle","volume":"125","year":"1993","journal-title":"Mol. Cell. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/ajpheart.2001.281.1.H241","article-title":"Relationship between capillary angiogenesis, fiber type, and fiber size in chronic systemic hypoxia","volume":"281","author":"Deveci","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1097\/00006123-199806000-00038","article-title":"Metabolic profiles of patients with subarachnoid hemorrhage treated by early surgery","volume":"42","author":"Kasuya","year":"1998","journal-title":"Neurosurgery"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.mehy.2003.12.014","article-title":"C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases","volume":"62","author":"Li","year":"2004","journal-title":"Med. Hypotheses."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00041433-200412000-00005","article-title":"C-reactive protein as a risk factor versus risk marker","volume":"15","author":"Trion","year":"2004","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.biocel.2013.04.025","article-title":"Muscle wasting in heart failure: An overview","volume":"45","author":"Steinbeck","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_83","first-page":"1690","article-title":"Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans","volume":"77","author":"Mastorakos","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0002-9149(01)02049-5","article-title":"C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease","volume":"88","author":"Madsen","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0891-5849(00)00420-2","article-title":"Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients","volume":"29","author":"Devaraj","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/sj.ejcn.1601459","article-title":"Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study","volume":"56","author":"Sierksma","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ncpendmet0716","article-title":"Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity","volume":"4","author":"Adams","year":"2008","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.peptides.2012.05.014","article-title":"Antimicrobial peptides: Clinical relevance and therapeutic implications","volume":"36","author":"Machado","year":"2012","journal-title":"Peptides"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/PHM.0b013e3181f71112","article-title":"Prevalence of 25-hydroxyvitamin D deficiency in the outpatient rehabilitation population","volume":"89","author":"Pellicane","year":"2010","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/MCO.0b013e328358fc2b","article-title":"Vitamin D in acute stress and critical illness","volume":"15","author":"Quraishi","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1479-5876-7-28","article-title":"Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis","volume":"7","author":"Jeng","year":"2009","journal-title":"J. Transl. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/bmj.330.7490.524","article-title":"Recent developments in vitamin D deficiency and muscle weakness among elderly people","volume":"330","author":"Venning","year":"2005","journal-title":"BMJ"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-2001-14831","article-title":"Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis","volume":"109","author":"Pfeifer","year":"2001","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/jama.291.9.1135","article-title":"Cell-free fetal DNA in maternal blood: Evolving clinical applications","volume":"291","author":"Simpson","year":"2004","journal-title":"JAMA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3945\/ajcn.115.113357","article-title":"Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly","volume":"103","author":"Rondanelli","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1080\/17453670610012926","article-title":"Metabolism and catabolism in hip fracture patients: Nutritional and anabolic intervention-a review","volume":"77","author":"Ljungqvist","year":"2006","journal-title":"Acta Orthop."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/geronj\/45.3.M101","article-title":"Predictors of functional recovery one year following hospital discharge for hip fracture: A prospective study","volume":"45","author":"Magaziner","year":"1990","journal-title":"J. Gerontol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/6\/637\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:39:50Z","timestamp":1760207990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/6\/637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":97,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6]]}},"alternative-id":["nu9060637"],"URL":"https:\/\/doi.org\/10.3390\/nu9060637","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,21]]}}}