{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:27:06Z","timestamp":1791516426488,"version":"4.3.4"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We evaluated the effect of red ginseng on toxicity, health-related quality of life (HRQL) and survival after adjuvant chemotherapy in patients with epithelial ovarian cancer (EOC). A total of 30 patients with EOC were randomly assigned to placebo (n = 15) and red ginseng groups (n = 15). All patients took placebo or red ginseng (3000 mg\/day) for three months. Then, we compared changes of genotoxicity, HRQL and survival between the two groups. As a result, red ginseng reduced micronuclei yield in comparison with placebo despite no difference of binucleated cells index. Although red ginseng increased serum levels of alanine aminotransferase and aspartate aminotransferase significantly, they were within the normal value. Moreover, there were no differences in adverse events between placebo and red ginseng groups. In terms of HRQL, red ginseng was associated with improved emotional functioning and decreased symptoms of fatigue, nausea and vomiting, and dyspnea, reduced anxiety and interference affecting life and improved daytime somnolence. However, there was no effect of red ginseng on prognosis of EOC. Conclusively, red ginseng may be safe and effective to reduce genotoxicity and improve HRQL despite no benefit of survival in patients with EOC who received chemotherapy.<\/jats:p>","DOI":"10.3390\/nu9070772","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T04:28:26Z","timestamp":1500524906000},"page":"772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-8671","authenticated-orcid":false,"given":"Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-332X","authenticated-orcid":false,"given":"Mi-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cheil General Hospital &amp; Women\u2019s Healthcare Center, Dankook University College of Medicine, Seoul 04619, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-3176","authenticated-orcid":false,"given":"Maria","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Su","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan 49241, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7115-4021","authenticated-orcid":false,"given":"Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea"},{"name":"Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3802\/jgo.2017.28.e45","article-title":"Major clinical research advances in gynecologic cancer in 2016: 10-year special edition","volume":"28","author":"Suh","year":"2017","journal-title":"J. Gynecol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00520-009-0733-0","article-title":"Nord-Ostdeutschen Gesellschaft fur Gynakologische Onkologie working group \u201cQuality of life\u201d. Development of the Berlin Symptom Checklist Ovary (BSCL-O) for the measurement of quality of life of patients with primary and recurrent ovarian cancer: Results of a phase I and II study","volume":"18","author":"Koensgen","year":"2010","journal-title":"Support. Care Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ygyno.2011.11.032","article-title":"The association between quality of life domains and overall survival in ovarian cancer patients during adjuvant chemotherapy: A Gynecologic Oncology Group Study","volume":"124","author":"Huang","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ygyno.2007.08.088","article-title":"The prognostic effects of performance status and quality of life scores on progression-free survival and overall survival in advanced ovarian cancer","volume":"108","author":"Carey","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1245\/s10434-014-4263-8","article-title":"Quality of Life in Platinum-Sensitive Recurrent Ovarian Cancer: Chemotherapy Versus Surgery Plus Chemotherapy","volume":"22","author":"Plotti","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/1097-0142(19890515)63:10<1944::AID-CNCR2820631013>3.0.CO;2-#","article-title":"Taxol toxicity. Epithelial necrosis in the gastrointestinal tract associated with polymerized microtubule accumulation and mitotic arrest","volume":"63","author":"Hruban","year":"1989","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1017\/S0029665114000603","article-title":"Oxidative stress, protein glycation and nutrition\u2014Interactions relevant to health and disease throughout the lifecycle","volume":"73","author":"Vlassopoulos","year":"2014","journal-title":"Proc. Nutr. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1142\/S0192415X14500359","article-title":"Traditional Chinese medicine: A treasured natural resource of anticancer drug research and development","volume":"42","author":"Wang","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jep.2011.12.024","article-title":"Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats","volume":"140","author":"He","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1016\/j.vaccine.2005.04.007","article-title":"The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response","volume":"23","author":"Rivera","year":"2005","journal-title":"Vaccine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1254\/jphs.FP0040184","article-title":"Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat","volume":"97","author":"Kim","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/exnr.2001.7841","article-title":"Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro","volume":"173","author":"Liao","year":"2002","journal-title":"Exp. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0006-291X(02)00870-7","article-title":"Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons","volume":"296","author":"Kim","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"183S","DOI":"10.1093\/jn\/137.1.183S","article-title":"Inflammation, cancer, and targets of ginseng","volume":"137","author":"Hofseth","year":"2007","journal-title":"J. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jep.2007.12.009","article-title":"Evidence-based Chinese medicine for cancer therapy","volume":"116","author":"Konkimalla","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/gme.0b013e3182325e4b","article-title":"Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: A double-blind randomized controlled trial","volume":"19","author":"Kim","year":"2012","journal-title":"Menopause"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2710.2006.00740.x","article-title":"Effects of sun ginseng on subjective quality of life in cancer patients: A double-blind, placebo-controlled pilot trial","volume":"31","author":"Kim","year":"2006","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/nprot.2007.77","article-title":"Cytokinesis-block micronucleus cytome assay","volume":"2","author":"Fenech","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/mutage\/geq063","article-title":"Automated image analysis of micronuclei by IMSTAR for biomonitoring","volume":"26","author":"Decordier","year":"2011","journal-title":"Mutagenesis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1023\/B:QURE.0000021692.81214.70","article-title":"Validation of the Korean version of the EORTC QLQ-C30","volume":"13","author":"Yun","year":"2004","journal-title":"Qual. Life Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpainsymman.2004.04.013","article-title":"Validation study of the korean version of the brief fatigue inventory","volume":"29","author":"Yun","year":"2005","journal-title":"J. Pain Symptom. Manag."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1159\/000079497","article-title":"Development of a cancer pain assessment tool in Korea: A validation study of a Korean version of the brief pain inventory","volume":"66","author":"Yun","year":"2004","journal-title":"Oncology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jpainsymman.2013.01.012","article-title":"Validation of the Edmonton Symptom Assessment System in Korean patients with cancer","volume":"46","author":"Kwon","year":"2013","journal-title":"J. Pain Symptom. Manag."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.sleep.2004.07.006","article-title":"Psychometric properties of the Medical Outcomes Study Sleep measure","volume":"6","author":"Hays","year":"2005","journal-title":"Sleep Med."},{"key":"ref_25","unstructured":"(2012, February 26). Power Analysis and Sample Size (PASS) 15 Software. Available online: https:\/\/www.ncss.com\/software\/pass\/."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mrrev.2008.05.006","article-title":"Micronuclei frequency in peripheral blood lymphocytes of cancer patients: A meta-analysis","volume":"659","author":"Iarmarcovai","year":"2008","journal-title":"Mutat. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1742-7843.2006.pto_348.x","article-title":"Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide","volume":"98","author":"Wang","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13020-019-0231-3","article-title":"Red ginseng and cancer treatment","volume":"14","author":"Wang","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5142\/jgr.2013.37.1","article-title":"The world ginseng market and the ginseng (Korea)","volume":"37","author":"Baeg","year":"2013","journal-title":"J. Ginseng. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0006-2952(99)00212-9","article-title":"Ginseng pharmacology: Multiple constituents and multiple actions","volume":"58","author":"Attele","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1039\/c0np00057d","article-title":"Isolation and analysis of ginseng: Advances and challenges","volume":"28","author":"Qi","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1475-2891-11-47","article-title":"Beneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: A randomized, double-blind, placebo-controlled trial","volume":"11","author":"Kim","year":"2012","journal-title":"Nutr. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.fct.2007.08.025","article-title":"Protective effects of total saponins from stem and leaf of Panax ginsengagainst cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells","volume":"46","author":"Zhang","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/mutage\/gei041","article-title":"Radioprotective potential of ginseng","volume":"20","author":"Lee","year":"2005","journal-title":"Mutagenesis"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1200\/JCO.2004.01.106","article-title":"Determining the relationship between toxicity and quality of life in an ovarian cancer chemotherapy clinical trial","volume":"22","author":"Butler","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Choi, J., Kim, T.H., Choi, T.Y., and Lee, M.S. (2013). Ginseng for health care: A systematic review of randomized controlled trials in Korean literature. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059978"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/nature03958","article-title":"Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines","volume":"437","author":"Shi","year":"2005","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/carcin\/bgl177","article-title":"An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans","volume":"28","author":"Bonassi","year":"2007","journal-title":"Carcinogenesis"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Yang, M., Lee, H.S., Hwang, M.W., and Jin, M. (2014). Effects of Korean red ginseng (Panax Ginseng Meyer) on bisphenol A exposure and gynecologic complaints: Single blind, randomized clinical trial of efficacy and safety. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-265"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jep.2014.09.028","article-title":"Efficacy and safety of Korean red ginseng for cold hypersensitivity in the hands and feet: A randomized, double-blind, placebo-controlled trial","volume":"158","author":"Park","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/1534735415580676","article-title":"High-Dose Asian Ginseng (Panax Ginseng) for Cancer-Related Fatigue: A Preliminary Report","volume":"14","author":"Yennurajalingam","year":"2015","journal-title":"Integr. Cancer Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/jnci\/djt181","article-title":"Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: A randomized, double-blind trial, N07C2","volume":"105","author":"Barton","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00520-009-0642-2","article-title":"Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: A randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA","volume":"18","author":"Barton","year":"2010","journal-title":"Support. Care Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kioukia-Fougia, N., Georgiadis, N., Tsarouhas, K., Vasilaki, F., Fragkiadaki, P., Meimeti, E., and Tsitsimpikou, C. (2016). Synthetic and natural nutritional supplements: Health \u201callies\u201d or risk to public health?. Recent Pat. Inflamm. Allergy Drug Discov., Epub ahead of print.","DOI":"10.2174\/1872213X10666160923163700"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.fct.2012.01.005","article-title":"Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1\/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisplatin-induced intracellular reactive oxygen species","volume":"50","author":"Lee","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1142\/S0192415X02000661","article-title":"Effects of red ginseng upon postoperative immunity and survival in patients with stage III gastric cancer","volume":"30","author":"Suh","year":"2002","journal-title":"Am. J. Chin. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11655-009-0415-2","article-title":"Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer","volume":"15","author":"Chen","year":"2009","journal-title":"Chin. J. Integr. Med."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/7\/772\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:43:13Z","timestamp":1760208193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/7\/772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,19]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["nu9070772"],"URL":"https:\/\/doi.org\/10.3390\/nu9070772","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,19]]}}}