{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:47:25Z","timestamp":1783529245992,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Hepatitis C virus infection and interferon treatment have shown to be risk factors for sleep disorder health-related quality of life. Aim: To determine whether the effects of resveratrol on sleep disorders were associated with different tests in subjects with chronic hepatitis C treated with Peg-IFN-\u03b1 and RBV. Patients and Methods: In this prospective, randomized, placebo controlled, double blind clinical trial, 30 subjects (Group A) with chronic hepatitis received Pegylated-Interferon-\u03b12b (1.5 mg\/kg per week), Ribavirin and placebo (N-acetylcysteine 600 mg and lactoferrin 23.6 g), while 30 subjects (Group B) received the same dosage of Pegylated-Interferon-\u03b12b, Ribavirin and association of N-acetylcysteine 600 mg, lactoferrin 23.6 g and Resveratrol 19.8 mg for 12 months. All subjects underwent laboratory exams and questionnaires to evaluate mood and sleep disorders (General Health Questionnaire (GHQ), Profile of Mood States (POMS), Pittsburgh Sleep Quality Inventory (PSQI), Epworth Sleepiness Scale (ESS)). Results: The comparison between Group A and Group B showed significant differences after six months in C-reactive protein (p &lt; 0.0001); after 12 months in aspartate aminotransferase (AST) (p &lt; 0.0001) Viremia (p &lt; 0.0001), HAI (p &lt; 0.0012) and C-reactive protein (p &lt; 0.0001); and at follow up in AST (p &lt; 0.0001), Viremia (p &lt; 0.0026) and C-reactive protein (p &lt; 0.0001). Significant differences were observed after 12 month and follow-up in General Health Questionnaire, after 1, 6, 12 and follow-up in Profile of Mood States, after 6, 12, follow-up in Pittsburgh Sleep Quality Inventory and Epworth Sleepiness Scale. Conclusions: Supplementation with Resveratrol decreased General Health Questionnaire score and reduced sleep disorders in patients treated with Peg\u2013IFN-\u03b1 and RBV.<\/jats:p>","DOI":"10.3390\/nu9080897","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T04:12:17Z","timestamp":1503288737000},"page":"897","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Resveratrol in Hepatitis C Patients Treated with Pegylated-Interferon-\u03b1-2b and Ribavirin Reduces Sleep Disturbance"],"prefix":"10.3390","volume":"9","author":[{"given":"Manuela","family":"Pennisi","sequence":"first","affiliation":[{"name":"Spinal Ospedale Cannizzaro, University of Catania, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Bertino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Systemic Diseases, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Gagliano","sequence":"additional","affiliation":[{"name":"Research Center \u201cThe Great Senescence\u201d, University of Catania, 95100 Catania, Italy"},{"name":"Neurovisual Science Technology (NEST), SpinLab, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-6377","authenticated-orcid":false,"given":"Michele","family":"Malaguarnera","sequence":"additional","affiliation":[{"name":"Research Center \u201cThe Great Senescence\u201d, University of Catania, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-6863","authenticated-orcid":false,"given":"Rita","family":"Bella","sequence":"additional","affiliation":[{"name":"Department \u201cG.F. Ingrassia\u201d, Section of Neurosciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Borz\u00ec","sequence":"additional","affiliation":[{"name":"Research Center \u201cThe Great Senescence\u201d, University of Catania, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Madeddu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Drago","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-4307","authenticated-orcid":false,"given":"Giulia","family":"Malaguarnera","sequence":"additional","affiliation":[{"name":"Research Center \u201cThe Great Senescence\u201d, University of Catania, 95100 Catania, Italy"},{"name":"Neurovisual Science Technology (NEST), SpinLab, 95100 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945\u20131965","volume":"61","author":"Smith","year":"2012","journal-title":"Morb. 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