{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:19:27Z","timestamp":1780694367958,"version":"3.54.1"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sk\u00e5ne University Hospital Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We conducted a double-blind placebo-controlled crossover pilot study to investigate the effect of oat betaglucans (\u03b2-glucan) on glycaemic control and variability in adults with type 1 diabetes (T1D; n = 14). Stomacol\u00ae tablets (1.53 g of \u03b2-glucan) or placebo (Plac) were administered three times daily before meals for two weeks. Glucose levels were monitored during the second week by continuous glucose monitoring (CGM). There was an increase in basic measures of glycaemic control (maximal glucose value 341 \u00b1 15 vs. 378 \u00b1 13 mg\/dL for Plac and \u03b2-glucan, p = 0.004), and average daily risk range (62 \u00b1 5 vs. 79 \u00b1 4 mg\/dL for Plac and \u03b2-glucan, p = 0.003) favouring Plac over \u03b2-glucan, but no increase in the M-value (the weighted average of the glucose values) or other more complex measures. Basic measures of glucose variability were also slightly increased during \u03b2-glucan treatment, with no difference in more complex measures. However, glycaemic variability increased between the first and last two CGM days on Plac, but remained unchanged on \u03b2-glucan. In conclusion, in this pilot study we were unable to demonstrate a general positive effect of \u03b2-glucan before meals on glucose control or variability in T1D.<\/jats:p>","DOI":"10.3390\/nu9091004","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T10:40:04Z","timestamp":1505212804000},"page":"1004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Oral Pre-Meal Administration of Betaglucans on Glycaemic Control and Variability in Subjects with Type 1 Diabetes"],"prefix":"10.3390","volume":"9","author":[{"given":"Anders","family":"Frid","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sk\u00e5ne University Hospital, 205 04 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tura","sequence":"additional","affiliation":[{"name":"Metabolic Unit, CNR Institute of Neuroscience, 35127 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pacini","sequence":"additional","affiliation":[{"name":"Metabolic Unit, CNR Institute of Neuroscience, 35127 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3270-9167","authenticated-orcid":false,"given":"Martin","family":"Ridderstr\u00e5le","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center, 2820 Gentofte, Denmark"},{"name":"Department of Clinical Sciences, Lund University, 205 04 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/ajcn\/75.5.834","article-title":"Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: Serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial","volume":"75","author":"Jenkins","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1753-4887.2011.00401.x","article-title":"Cholesterol-lowering effects of oat \u03b2-glucan","volume":"69","author":"Othman","year":"2011","journal-title":"Nutr. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1096\/fj.201600465R","article-title":"Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat \u03b2-glucan","volume":"30","author":"Gunness","year":"2016","journal-title":"FASEB J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Shen, X.L., Zhao, T., Zhou, Y., Shi, X., Zou, Y., and Zhao, G. (2016). Effect of Oat \u03b2-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials. Nutrients, 8.","DOI":"10.3390\/nu8010039"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Panel on Dietetic Products, Nutrition and Allergies (NDA) (2011). Scientific Opinion on the substantiation of health claims related to beta-glucans from oats and barley and maintenance of normal blood LDL-cholesterol concentrations (ID 1236, 1299), increase in satiety leading to a reduction in energy intake (ID 851, 852), reduction of post-prandial glycaemic responses (ID 821, 824), and \u201cdigestive function\u201d (ID 850) pursuant to Article 13(1) of Regulation (EC) No 1924\/2006. EFSA J., 9.","DOI":"10.2903\/j.efsa.2011.2207"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1753-4887.2012.00494.x","article-title":"Role of dietary beta-glucans in the prevention of the metabolic syndrome","volume":"70","author":"Cloetens","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00394-008-0698-7","article-title":"Oat: Unique among cereals","volume":"47","author":"Butt","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11154-016-9347-2","article-title":"Glucose variability, HbA1c and microvascular complications","volume":"17","year":"2016","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S2213-8587(16)00039-5","article-title":"Non-insulin drugs to treat hyperglycaemia in type 1 diabetes mellitus","volume":"4","author":"Frandsen","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1089\/dia.2008.0132","article-title":"Interpretation of continuous glucose monitoring data: Glycemic variability and quality of glycemic control","volume":"11","author":"Rodbard","year":"2009","journal-title":"Diabetes Technol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1089\/dia.2009.0015","article-title":"New and improved methods to characterize glycemic variability using continuous glucose monitoring","volume":"11","author":"Rodbard","year":"2009","journal-title":"Diabetes Technol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jdiacomp.2015.07.014","article-title":"Comparison of glycemic control and variability in patients with type 2 and posttransplantation diabetes mellitus","volume":"29","author":"Werzowa","year":"2015","journal-title":"J. Diabetes Complicat."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"484231","DOI":"10.1155\/2015\/484231","article-title":"Four points pre-prandial self-monitoring of blood glucose for the assessment of glycemic control and variability in patients with type 2 diabetes treated with insulin and vildagliptin","volume":"2015","author":"Tura","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/07315724.2007.10719641","article-title":"Beta-glucan from two sources of oat concentrates affect postprandial glycemia in relation to the level of viscosity","volume":"26","author":"Panahi","year":"2007","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1017\/S000711451600341X","article-title":"The effect of oat \u03b2-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: A systematic review and meta-analysis of randomised-controlled trials","volume":"116","author":"Ho","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ejcn.2013.25","article-title":"Review of human studies investigating the post-prandial blood-glucose lowering ability of oat and barley food products","volume":"67","author":"Tosh","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/nutrit\/nuv063","article-title":"Dietary fiber and satiety: The effects of oats on satiety","volume":"74","author":"Rebello","year":"2016","journal-title":"Nutr. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1467-789X.2011.00895.x","article-title":"Effects of dietary fibre on subjective appetite, energy intake and body weight: A systematic review of randomized controlled trials","volume":"12","author":"Wanders","year":"2011","journal-title":"Obes. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Steinert, R.E., Raederstorff, D., and Wolever, T.M. (2016). Effect of Consuming Oat Bran Mixed in Water before a Meal on Glycemic Responses in Healthy Humans-A Pilot Study. Nutrients, 8.","DOI":"10.3390\/nu8090524"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2337\/dc12-1609","article-title":"Relationships between gastric emptying, postprandial glycemia, and incretin hormones","volume":"36","author":"Marathe","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0140-6736(79)90904-8","article-title":"Fibre in diabetes","volume":"1","author":"Jenkins","year":"1979","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/pdi.1960030515","article-title":"Guar in NIDD: Effect of different modes of administration on plasma glucose and insulin responses to a starch meal","volume":"3","author":"Fuessl","year":"1986","journal-title":"Pract. Diabetes Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1210\/jc.2005-2644","article-title":"Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes","volume":"91","author":"Gentilcore","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2337\/dc09-0723","article-title":"Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes","volume":"32","author":"Ma","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1016\/j.diabres.2015.02.019","article-title":"Sustained effects of a protein \u201cpreload\u201d on glycaemia and gastric emptying over 4 weeks in patients with type 2 diabetes: A randomized clinical trial","volume":"108","author":"Ma","year":"2015","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.trac.2014.09.005","article-title":"Emerging trends in optical sensing of glycemic markers for diabetes monitoring","volume":"64","author":"Pandey","year":"2015","journal-title":"TrAC Trends Anal. Chem."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/9\/1004\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:44:40Z","timestamp":1760208280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/9\/9\/1004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9]]}},"alternative-id":["nu9091004"],"URL":"https:\/\/doi.org\/10.3390\/nu9091004","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,12]]}}}