{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:02:08Z","timestamp":1789387328060,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to evaluate the effects of \u03b2-glucan ingestion (Saccharomyces cerevisiae) on the plasmatic levels of tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-10 (IL-10), alveolar bone loss, and pancreatic \u03b2-cell function (HOMA-BF) in diabetic rats with periodontal disease (PD). Besides, intestinal morphology was determined by the villus\/crypt ratio. A total of 48 Wistar rats weighing 203 \u00b1 18 g were used. Diabetes was induced by the intraperitoneal injection of streptozotocin (80 mg\/kg) and periodontal inflammation, by ligature. The design was completely randomized in a factorial scheme 2 \u00d7 2 \u00d7 2 (diabetic or not, with or without periodontitis, and ingesting \u03b2-glucan or not). The animals received \u03b2-glucan by gavage for 28 days. Alveolar bone loss was determined by scanning electron microscopy (distance between the cementoenamel junction and alveolar bone crest) and histometric analysis (bone area between tooth roots). \u03b2-glucan reduced plasmatic levels of TNF-\u03b1 in diabetic animals with PD and of IL-10 in animals with PD (p &lt; 0.05). \u03b2-glucan reduced bone loss in animals with PD (p &lt; 0.05). In diabetic animals, \u03b2-glucan improved \u03b2-cell function (p &lt; 0.05). Diabetic animals had a higher villus\/crypt ratio (p &lt; 0.05). In conclusion, \u03b2-glucan ingestion reduced the systemic inflammatory profile, prevented alveolar bone loss, and improved \u03b2-cell function in diabetic animals with PD.<\/jats:p>","DOI":"10.3390\/nu9091016","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T10:04:49Z","timestamp":1505383489000},"page":"1016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effects of \u03b2-Glucans Ingestion on Alveolar Bone Loss, Intestinal Morphology, Systemic Inflammatory Profile, and Pancreatic \u03b2-Cell Function in Rats with Periodontitis and Diabetes"],"prefix":"10.3390","volume":"9","author":[{"given":"Viviam","family":"De O. Silva","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Lobato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-3108","authenticated-orcid":false,"given":"Eric","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3530-9345","authenticated-orcid":false,"given":"M\u00e1rcio","family":"Zangeronimo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo","family":"De Sousa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0502-2554","authenticated-orcid":false,"given":"Luciano","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Federal University of Lavras (UFLA), Lavras 37200-000, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.1111\/jcpe.12077","article-title":"Diabetes and periodontal diseases: Consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"40","author":"Chapple","year":"2013","journal-title":"J. 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