{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:00:39Z","timestamp":1791986439889,"version":"4.4.0"},"reference-count":49,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn\u2019s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the association between vitamin D status and the Harvey-Bradshaw Index (HBI). The deficient vitamin D group (\u226429 nmol\/L) had significantly higher mean hs-CRP levels compared with the three other categories of vitamin D status (p &lt; 0.05). CRP was significantly lower in all of the other groups compared with the vitamin D-deficient group, which had Coef. = 12.8 units lower (95% CI \u221219.8, \u22125.8), Coef. 7.85 units (95% CI \u221214.9, \u22120.7), Coef. 9.87 units (95% CI \u221217.6, \u22122.0) for the vitamin D insufficient, adequate, and optimal groups, respectively. The vitamin D status was associated with the HBI active disease category. However, the difference in the odds ratio compared with the reference category of deficient vitamin D category was only significant in the insufficient category (odds ratio = 3.45, p = 0.03, 95% CI 1.0, 10.8). Vitamin D status was inversely associated with indicators of disease activity in Crohn\u2019s disease, particularly with the objective measures of inflammation.<\/jats:p>","DOI":"10.3390\/nu9101112","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T13:06:19Z","timestamp":1507813579000},"page":"1112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn\u2019s Disease Patients in Canada"],"prefix":"10.3390","volume":"9","author":[{"given":"Dania","family":"Alrefai","sequence":"first","affiliation":[{"name":"College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Digestive Care & Endoscopy, Department of Community Health and Epidemiology, Dalhousie University, Truro, NS B2N 5E3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"El-Matary","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-0425","authenticated-orcid":false,"given":"Susan","family":"Whiting","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Aljebreen","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-1457","authenticated-orcid":false,"given":"Naghmeh","family":"Mirhosseini","sequence":"additional","affiliation":[{"name":"Pure North S\u2019Energy Foundation, Calgary, AB T2R 0C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-8385","authenticated-orcid":false,"given":"Hassan","family":"Vatanparast","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ibd.20352","article-title":"New global map of Crohn\u2019s disease: Genetic, environmental, and socioeconomic correlations","volume":"14","author":"Economou","year":"2008","journal-title":"Inflamm. 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