{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:15:30Z","timestamp":1791933330986,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Anorexia Nervosa Foundation","award":["23-13"],"award-info":[{"award-number":["23-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>High physical activity (PA) in patients with anorexia nervosa (AN) is hypothesized to be, at least in part, a consequence of hypoleptinemia. However, most studies on the association of leptin and PA in AN were performed in adolescents or young adults, and PA was generally measured with subjective tools. We aimed to explore the association of leptin and PA in adults with AN using an objective technique to quantify PA. Using a cross-sectional, observational design, we analyzed body fat (bioelectrical impedance), PA (accelerometry, SenseWear\u2122 armband) and plasma leptin (ELISA) in 61 women with AN (median age: 25 years, range: 18\u201352 years; median BMI: 14.8 \u00b1 2.0 kg\/m2) at the start of hospitalization. Results indicated a mean step count per day of 12,841 \u00b1 6408 (range: 3956\u201337,750). Leptin was closely associated with BMI and body fat (\u03c1 = 0.508 and \u03c1 = 0.669, p &lt; 0.001), but not with steps (\u03c1 = 0.015, p = 0.908). Moreover, no significant association was observed between BMI and steps (\u03c1 = 0.189, p = 0.146). In conclusion, there was no simple, linear association of leptin and PA, highlighting the need for more complex and non-linear models to analyze the association of leptin and PA in adults with AN in future studies.<\/jats:p>","DOI":"10.3390\/nu9111210","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T04:43:13Z","timestamp":1509684193000},"page":"1210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Leptin and Physical Activity in Adult Patients with Anorexia Nervosa: Failure to Demonstrate a Simple Linear Association"],"prefix":"10.3390","volume":"9","author":[{"given":"Andreas","family":"Stengel","sequence":"first","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, 12200 Berlin, Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin 13353, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Elbelt","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine with Gastroenterology and Nephrology, Division for Endocrinology, Diabetes and Nutrition, Charit\u00e9-Universit\u00e4tsmedizin Berlin, 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Correll","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin 13353, Germany"},{"name":"Feinstein Institute for Medical Research at Hofstra\/Northwell, Islandia, NY 11749, USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11549, USA"},{"name":"Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Rose","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-3552","authenticated-orcid":false,"given":"Tobias","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9-Universit\u00e4tsmedizin Berlin, 12200 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Carrera, O., Adan, R.A., Gutierrez, E., Danner, U.N., Hoek, H.W., van Elburg, A.A., and Kas, M.J. 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