{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:02:02Z","timestamp":1789192922796,"version":"build-2803163510"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["U54MD007587"],"award-info":[{"award-number":["U54MD007587"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Minority Health and Health Disparities","award":["5R25MD007607"],"award-info":[{"award-number":["5R25MD007607"]}]},{"name":"National Institute of Minority Health and Health Disparities","award":["5G12MD007579"],"award-info":[{"award-number":["5G12MD007579"]}]},{"name":"National Institute of Minority Health and Health Disparities","award":["U54MD007579"],"award-info":[{"award-number":["U54MD007579"]}]},{"name":"National Institute of Minority Health and Health Disparities","award":["R21MD013674"],"award-info":[{"award-number":["R21MD013674"]}]},{"name":"National Institute of Minority Health and Health Disparities","award":["5P60MD006912"],"award-info":[{"award-number":["5P60MD006912"]}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["133798-PF-19-120-01-CPPB"],"award-info":[{"award-number":["133798-PF-19-120-01-CPPB"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["2U54CA163071"],"award-info":[{"award-number":["2U54CA163071"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["2U54CA163068"],"award-info":[{"award-number":["2U54CA163068"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA180831"],"award-info":[{"award-number":["R21CA180831"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nursing Reports"],"abstract":"<jats:p>Background: Anxiety and depression symptoms are known to increase cancer symptom burden, yet little is known about the longitudinal integrations of these among Hispanic\/Latinx patients. The goal of this study was to explore the trajectory and longitudinal interactions among anxiety and depression, cancer symptom burden, and health-related quality of life in Hispanic\/Latinx cancer patients undergoing chemotherapy. Methods: Baseline behavioral assessments were performed before starting chemotherapy. Follow-up behavioral assessments were performed at 3, 6, and 9 months after starting chemotherapy. Descriptive statistics, chi-square tests, Fisher\u2019s exact tests, and Mann\u2013Whitney tests explored associations among outcome variables. Adjusted multilevel mixed-effects linear regression models were also used to evaluate the association between HADS scores, follow-up visits, FACT\u2014G scale, MDASI scale, and sociodemographic variables. Results: Increased cancer symptom burden was significantly related to changes in anxiety symptoms\u2019 scores (adjusted \u03b2^ = 0.11 [95% CI: 0.02, 0.19]. Increased quality of life was significantly associated with decreased depression and anxiety symptoms (adjusted \u03b2^ = \u22120.33; 95% CI: \u22120.47, \u22120.18, and 0.38 adjusted \u03b2^= \u22120.38; 95% CI: \u22120.55, \u22120.20, respectively). Conclusions: Findings highlight the need to conduct periodic mental health screenings among cancer patients initiating cancer treatment.<\/jats:p>","DOI":"10.3390\/nursrep11020044","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T22:18:29Z","timestamp":1623277109000},"page":"475-483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Brief Report: Hispanic Patients\u2019 Trajectory of Cancer Symptom Burden, Depression, Anxiety, and Quality of Life"],"prefix":"10.3390","volume":"11","author":[{"given":"Eida M.","family":"Castro-Figueroa","sequence":"first","affiliation":[{"name":"Ponce Health Sciences University-Ponce Research Institute, Ponce 00716, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Normarie","family":"Torres-Blasco","sequence":"additional","affiliation":[{"name":"Ponce Health Sciences University-Ponce Research Institute, Ponce 00716, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros C.","family":"Rosal","sequence":"additional","affiliation":[{"name":"Population and Quantitative Health Sciences, School of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Ponce Health Sciences University-Ponce Research Institute, Ponce 00716, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallesca P.","family":"Castro-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Christiana Care Health Center-Helen F. Graham Care Center, Wilmington, DE 19899, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilis","family":"Gonz\u00e1lez-Lorenzo","sequence":"additional","affiliation":[{"name":"Ponce Health Sciences University-Ponce Research Institute, Ponce 00716, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"V\u00e9lez-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Ponce Health Sciences University-Ponce Research Institute, Ponce 00716, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Toro-Bahamonde","sequence":"additional","affiliation":[{"name":"Merck Pharmaceutical, Oncology Department, Kenilworth, NJ 07033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-5657","authenticated-orcid":false,"given":"Rosario","family":"Costas-Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Department of Psychiatry and Behavioral Sciences, Puerto Rico, CA 00984, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-5339","authenticated-orcid":false,"given":"Guillermo N.","family":"Armaiz-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Ponce Health Sciences University-Ponce Research Institute, Ponce 00716, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Jim","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","article-title":"Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: A meta-analysis of 94 interview-based studies","volume":"12","author":"Mitchell","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1470-2045(13)70244-4","article-title":"Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: A systematic review and meta-analysis","volume":"14","author":"Mitchell","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/pon.4328","article-title":"Incidence of depression and anxiety among women newly diagnosed with breast or genital organ cancer in Germany","volume":"26","author":"Jacob","year":"2017","journal-title":"Psycho-Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.pop.2009.07.008","article-title":"Depression in cancer patients","volume":"36","author":"Snyderman","year":"2009","journal-title":"Prim. 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