{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:22:12Z","timestamp":1774023732356,"version":"3.50.1"},"reference-count":115,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01165\u201316\/PPM-00399\u201318"],"award-info":[{"award-number":["APQ-01165\u201316\/PPM-00399\u201318"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["PQ fellowship"],"award-info":[{"award-number":["PQ fellowship"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior, Brasil","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Arthropod-borne viruses (arboviruses) are a significant public health problem worldwide. Vaccination is considered one of the most effective ways to control arbovirus diseases in the human population. Nanoparticles have been widely explored as new vaccine platforms. Although nanoparticles\u2019 potential to act as new vaccines against infectious diseases has been identified, nanotechnology\u2019s impact on developing new vaccines to prevent arboviruses is unclear. Thus, we used a comprehensive bibliographic survey to integrate data concerning the use of diverse nanoparticles as vaccines against medically important arboviruses. Our analysis showed that considerable research had been conducted to develop and evaluate nanovaccines against Chikungunya virus, Dengue virus, Zika virus, Japanese encephalitis virus, and West Nile virus. The main findings indicate that nanoparticles have great potential for use as a new vaccine system against arboviruses. Most of the studies showed an increase in neutralizing antibody production after mouse immunization. Nevertheless, even with significant advances in this field, further efforts are necessary to address the nanoparticles\u2019 potential to act as a vaccine against these arboviruses. To promote advances in the field, we proposed a roadmap to help researchers better characterize and evaluate nanovaccines against medically important arboviruses.<\/jats:p>","DOI":"10.3390\/pathogens10010036","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T10:35:12Z","timestamp":1609842912000},"page":"36","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nanoparticles as Vaccines to Prevent Arbovirus Infection: A Long Road Ahead"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2479-4429","authenticated-orcid":false,"given":"Gabriel Augusto Pires","family":"de Souza","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Vacinas, Departamento de Microbiologia e Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, Brazil"},{"name":"Laborat\u00f3rio de V\u00edrus, Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00edssa Prado","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia B\u00e1sica e Aplicada, Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Lemes","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, NUPEB, Universidade Federal de Ouro Preto, Ouro Preto 35400-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9883-1392","authenticated-orcid":false,"given":"Cyntia Silva","family":"Ferreira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, NUPEB, Universidade Federal de Ouro Preto, Ouro Preto 35400-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-8111","authenticated-orcid":false,"given":"Breno","family":"de Mello Silva","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas, NUPEB, Universidade Federal de Ouro Preto, Ouro Preto 35400-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Fr\u00f3es Goulart","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vacinas, Departamento de Microbiologia e Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3391-7766","authenticated-orcid":false,"given":"Jo\u00e3o Francisco Vit\u00f3rio","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vacinas, Departamento de Microbiologia e Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Carlos Vilela Vieira","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vacinas, Departamento de Microbiologia e Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Cosme Cotta","family":"Malaquias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vacinas, Departamento de Microbiologia e Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f4natas Santos","family":"Abrah\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de V\u00edrus, Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-384X","authenticated-orcid":false,"given":"Luiz Felipe Leomil","family":"Coelho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Vacinas, Departamento de Microbiologia e Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas, Alfenas 37130-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1477-3155-9-55","article-title":"Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines","volume":"9","author":"Mahapatro","year":"2011","journal-title":"J. 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