{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:39:56Z","timestamp":1771558796368,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Baasch-Medicus Stiftung","award":["2018"],"award-info":[{"award-number":["2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>After an acute hepatitis E (HEV) outbreak in Southern Switzerland, in January 2017 the local public health authorities started an active program of food chain control and public education. In this retrospective study, we analysed all laboratory-confirmed acute cases of HEV infection diagnosed between 2014 and 2020. In the period before the public health intervention, the number of cases increased steadily from 2014 (4 of 40 tests, 10%) reaching a peak in the last quarter of 2016 (42 of 285 tests, 14.7 %). Afterwards, the number of positive cases decreased steadily, reaching its lowest value (0.3%) in the second quarter of 2019. There was a statistically significant difference between the frequency of positive cases and period of testing, i.e., before and after the introduction of the public health interventions. Our study shows that active public health measures to control sausages containing raw pork liver can reduce the prevalence of HEV infection.<\/jats:p>","DOI":"10.3390\/pathogens10020107","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T03:31:30Z","timestamp":1611286290000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Control of Raw Pork Liver Sausage Production Can Reduce the Prevalence of HEV Infection"],"prefix":"10.3390","volume":"10","author":[{"given":"Paolo","family":"Ripellino","sequence":"first","affiliation":[{"name":"Neurocenter of Southern Switzerland, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-4025","authenticated-orcid":false,"given":"Enea","family":"Pianezzi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Martinetti","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Zehnder","sequence":"additional","affiliation":[{"name":"Synlab Ticino, 6934 Bioggio, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Mathis","sequence":"additional","affiliation":[{"name":"Unilabs Ticino, 6932 Breganzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-8136","authenticated-orcid":false,"given":"Petra","family":"Giannini","sequence":"additional","affiliation":[{"name":"Cantonal Food Control Authority, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Forrer","sequence":"additional","affiliation":[{"name":"Cantonal Food Control Authority, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Merlani","sequence":"additional","affiliation":[{"name":"Cantonal Service for Health, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry R.","family":"Dalton","sequence":"additional","affiliation":[{"name":"University of Applied Sciences and Arts of Southern Switzerland, 6501 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-7832","authenticated-orcid":false,"given":"Orlando","family":"Petrini","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospital, Truro TR1 3LJ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Bihl","sequence":"additional","affiliation":[{"name":"San Giovanni Hospital, 6500 Bellinzona, Switzerland"},{"name":"H\u00f4pitaux Universitaires de Gen\u00e8ve, 1205 Gen\u00e8ve, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-2619","authenticated-orcid":false,"given":"Stefano","family":"Fontana","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service CRS Southern Switzerland, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland, 6900 Lugano, Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17086","DOI":"10.1038\/nrdp.2017.86","article-title":"Hepatitis E virus infection","volume":"3","author":"Kamar","year":"2017","journal-title":"Nat. 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