{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:24Z","timestamp":1791346644821,"version":"4.3.1"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["P30-EY06360"],"award-info":[{"award-number":["P30-EY06360"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Recent Ebola epidemics, the ongoing COVID-19 pandemic, and emerging infectious disease threats have highlighted the importance of global infectious diseases and responses to public health emergencies. Ophthalmologists are essential health care workers who provide urgent and emergent vision care services during outbreaks and address the ocular consequences of epidemic and pandemic infectious diseases. In 2017, the World Health Organization (WHO) identified high priority pathogens likely to cause a future epidemic with the goal of guiding research and development to improve diagnostic tests, vaccines, and medicines. These measures were necessary to better inform and respond to public health emergencies. Given the ocular complications associated with emerging infectious diseases, there is a need to recognize the ophthalmic sequelae for future vision health preparedness for potential future outbreaks. The WHO High Priority pathogens list provides a roadmap for ophthalmologists and subspecialty providers that will guide strategic areas of research for clinical care and preparedness for future pandemic threats. This review summarizes these key viral pathogens, summarizes major systemic disease findings, and delineates relevant ocular complications of the WHO High Priority pathogens list, including Crimean-Congo hemorrhagic fever, Filovirus diseases (Ebola virus disease and Marburg hemorrhagic fever), human Coronaviruses, Lassa Fever, Nipah virus infection, Zika, and Rift Valley fever.<\/jats:p>","DOI":"10.3390\/pathogens10040442","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T21:27:44Z","timestamp":1617917264000},"page":"442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["World Health Organization High Priority Pathogens: Ophthalmic Disease Findings and Vision Health Perspectives"],"prefix":"10.3390","volume":"10","author":[{"given":"Sanjana","family":"Kuthyar","sequence":"first","affiliation":[{"name":"Emory Eye Center, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey L.","family":"Anthony","sequence":"additional","affiliation":[{"name":"Emory Eye Center, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-9202","authenticated-orcid":false,"given":"Tolulope","family":"Fashina","sequence":"additional","affiliation":[{"name":"Emory Eye Center, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Yeh","sequence":"additional","affiliation":[{"name":"Emory Eye Center, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA"},{"name":"Department of Ophthalmology, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE 68105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica G.","family":"Shantha","sequence":"additional","affiliation":[{"name":"Emory Eye Center, Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMp1613577","article-title":"New Vaccines against Epidemic Infectious Diseases","volume":"376","author":"Gouglas","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_2","unstructured":"(2021, February 16). Prioritizing Diseases for Research and Development in Emergency Contexts. Available online: https:\/\/www.who.int\/activities\/prioritizing-diseases-for-research-and-development-in-emergency-contexts."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/archophthalmol.2011.64","article-title":"Fred Loe, MD, and the history of trachoma","volume":"129","author":"Feibel","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-3156.2010.02521.x","article-title":"Epidemiology and control of trachoma: Systematic review","volume":"15","author":"Hu","year":"2010","journal-title":"Trop. Med. Int. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1001\/jamaophthalmol.2019.1956","article-title":"Characterization of retinopathy among patients with Yellow Fever during 2 outbreaks in Southeastern Brazil","volume":"137","author":"Cunha","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(16)00006-4","article-title":"Zika virus in Brazil and macular atrophy in a child with microcephaly","volume":"387","author":"Ventura","year":"2016","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Shantha, J.G., Yeh, S., and Acharya, N. (2019). Insights from 2 outbreaks in southeastern Brazil: Yellow Fever retinopathy. JAMA Ophthalmol.","DOI":"10.1001\/jamaophthalmol.2019.1936"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/ICU.0000000000000426","article-title":"An update on ocular complications of Ebola virus disease","volume":"28","author":"Shantha","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_9","unstructured":"World Health Organization (2020, December 27). Emergencies-Disease Outbreaks. Available online: https:\/\/www.who.int\/emergencies\/diseases\/en\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ajo.2008.11.014","article-title":"Ocular findings in patients with Crimean-Congo hemorrhagic fever","volume":"147","author":"Engin","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/jamaophthalmol.2020.1291","article-title":"Characteristics of Ocular Findings of Patients with Coronavirus Disease 2019 (COVID-19) in Hubei Province, China","volume":"138","author":"Wu","year":"2020","journal-title":"JAMA Ophthalmol."},{"key":"ref_12","unstructured":"World Health Organization (2020, December 28). Marburg Virus Disease. Available online: https:\/\/www.who.int\/health-topics\/marburg-virus-disease\/#tab=tab_2]."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/bmj.4.5995.489","article-title":"Outbreake of Marburg virus disease in Johannesburg","volume":"4","author":"Gear","year":"1975","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/bjo.61.4.265","article-title":"Uveal involvement in Marburg virus disease","volume":"61","author":"Kuming","year":"1977","journal-title":"Br. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ophtha.2016.10.011","article-title":"Ophthalmic Manifestations and Causes of Vision Impairment in Ebola Virus Disease Survivors in Monrovia, Liberia","volume":"124","author":"Shantha","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/IIO.0000000000000068","article-title":"Emerging Causes of Viral-associated Uveitis","volume":"55","author":"Connors","year":"2015","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMoa1805435","article-title":"A Longitudinal Study of Ebola Sequelae in Liberia","volume":"380","author":"Sneller","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_18","unstructured":"(2020, December 28). COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. Available online: https:\/\/gisanddata.maps.arcgis.com\/apps\/opsdashboard\/index.html#\/bda7594740fd40299423467b48e9ecf6."},{"key":"ref_19","unstructured":"World Health Organization (2020, December 26). Consensus Document on the Epidemiology of Severe Acute Respiratory Syndrome (SARS). Available online: https:\/\/www.who.int\/csr\/sars\/en\/WHOconsensus.pdf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3201\/eid2602.190697","article-title":"Middle East Respiratory Syndrome Coronavirus Transmission","volume":"26","author":"Killerby","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_21","unstructured":"World Health Organization (2020, December 28). Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/middle-east-respiratory-syndrome-coronavirus-(mers-cov)."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1016\/S1473-3099(20)30484-9","article-title":"Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics","volume":"20","author":"Petersen","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/bjo.2003.035931","article-title":"The severe acute respiratory syndrome coronavirus in tears","volume":"88","author":"Loon","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"ref_24","first-page":"411","article-title":"SARS-CoV-2 and the Eye: Implications for the Retina Specialist from Human Coronavirus Outbreaks and Animal Models","volume":"4","author":"Kennedy","year":"2020","journal-title":"J. Vitr. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40942-016-0057-4","article-title":"Arboviruses and the eye","volume":"3","author":"Ventura","year":"2017","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jtos.2020.03.010","article-title":"The evidence of SARS-CoV-2 infection on ocular surface","volume":"18","author":"Zhang","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Landecho, M.F., Yuste, J.R., G\u00e1ndara, E., Sunsundegui, P., Quiroga, J., Alcaide, A.B., and Garc\u00eda-Layana, A. (2020). COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease?. J. Int. Med.","DOI":"10.1111\/joim.13156"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/S0140-6736(20)31014-X","article-title":"Retinal findings in patients with COVID-19","volume":"395","author":"Marinho","year":"2020","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/bmj.327.7426.1271","article-title":"Lassa fever: Epidemiology, clinical features, and social consequences","volume":"327","author":"Richmond","year":"2003","journal-title":"BMJ"},{"key":"ref_30","unstructured":"Centers for Disease Control and Prevention (2020, December 28). (CDC) Lassa Fever-Sign and Symptoms, Available online: https:\/\/www.cdc.gov\/vhf\/lassa\/symptoms\/index.html."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Li, A.L., Grant, D., Gbakie, M., Kanneh, L., Mustafa, I., Bond, N., Engel, E., Schieffelin, J., Vandy, M.J., and Yeh, S. (2020). Ophthalmic manifestations and vision impairment in Lassa fever survivors. PLoS ONE.","DOI":"10.1371\/journal.pone.0243766"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3201\/eid2505.181254","article-title":"Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model","volume":"25","author":"Gary","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e01875-17","DOI":"10.1128\/JCM.01875-17","article-title":"Nipah Virus Infection","volume":"56","author":"Ang","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1017\/S0950268819000086","article-title":"Nipah virus infection: A review","volume":"147","author":"Shariff","year":"2019","journal-title":"Epidemiol. Infect."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Goh, K.J., Tan, C.T., Chew, N.K., Tan, P.S., Kamarulzaman, A., Sarji, S.A., Wong, K.T., Abdullah, B.J., Chua, K.B., and Lam, S.K. (2000). Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N. Engl. J. Med.","DOI":"10.1056\/NEJM200004273421701"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5582\/irdr.2018.01130","article-title":"Nipah virus disease: A rare and intractable disease","volume":"8","author":"Banerjee","year":"2019","journal-title":"Intract. Rare Dis. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/jnnp.74.1.131","article-title":"Late clinical and magnetic resonance imaging follow up of Nipah virus infection","volume":"74","author":"Lim","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cll.2017.01.004","article-title":"Rift Valley Fever","volume":"37","author":"Hartman","year":"2017","journal-title":"Clin. Lab. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ophtha.2004.09.018","article-title":"Ocular complications of Rift Valley fever outbreak in Saudi Arabia","volume":"112","author":"Abboud","year":"2005","journal-title":"Ophthalmology"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gupta, V., Nguyen, Q.D., LeHoang, P., and Herbort, C.P. (2017). Rift Valley Fever Uveitis. The Uveitis Atlas, Springer.","DOI":"10.1007\/978-81-322-2506-5"},{"key":"ref_41","unstructured":"World Health Organization (WHO) (2020, December 28). Ebola Virus Disease. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ebola-virus-disease."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/ICU.0000000000000420","article-title":"Zika virus and the eye","volume":"28","author":"Ventura","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.survophthal.2014.07.003","article-title":"Dengue eye disease","volume":"60","author":"Ng","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.2217\/fvl.11.79","article-title":"Clinical aspects of Marburg hemorrhagic fever","volume":"6","author":"Mehedi","year":"2011","journal-title":"Future Virol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Cooper, T.K., Sword, J., Johnson, J.C., Bonilla, A., Hart, R., Liu, D.X., Bernbaum, J.G., Cooper, K., Jahrling, P.B., and Hensley, L.E. (2018). New Insights into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model. J. Infect. Dis.","DOI":"10.1093\/infdis\/jiy367"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJMsr1904253","article-title":"The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018\u20132019","volume":"381","author":"Moeti","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Maxmen, A. (2020). Second-deadliest Ebola outbreak ends in Democratic Republic of the Congo. Nat. Cell Biol.","DOI":"10.1038\/d41586-020-01950-0"},{"key":"ref_48","unstructured":"(2020, December 26). Coronavirus, Available online: https:\/\/www.cdc.gov\/coronavirus\/types.html."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/ceo.13500","article-title":"Viral retinitis: Diagnosis and management in the era of biologic immunosuppression: A review","volume":"47","author":"Wu","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/bjophthalmol-2020-316304","article-title":"Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease","volume":"104","author":"Chen","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-74446-6","article-title":"Retinal involvement and ocular findings in COVID-19 pneumonia patients","volume":"10","author":"Pirraglia","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_52","unstructured":"(2020, December 27). Nipah Virus-India World Health Organization. Available online: https:\/\/www.who.int\/csr\/don\/07-august-2018-nipah-virus-india\/en\/."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3201\/eid2309.161922","article-title":"Convergence of Humans, Bats, Trees, and Culture in Nipah Virus Transmission, Bangladesh","volume":"23","author":"Gurley","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.tmaid.2016.05.008","article-title":"Ophthalmologic aspects of chikungunya infection","volume":"14","author":"Chowdhury","year":"2016","journal-title":"Travel Med. Infect. Dis."}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/4\/442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:26:35Z","timestamp":1760361995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/4\/442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["pathogens10040442"],"URL":"https:\/\/doi.org\/10.3390\/pathogens10040442","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]}}}