{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:38:48Z","timestamp":1765546728135,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/2002.930\/2016"],"award-info":[{"award-number":["E-26\/2002.930\/2016"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000193","name":"International Development Research Centre","doi-asserted-by":"publisher","award":["108411-001"],"award-info":[{"award-number":["108411-001"]}],"id":[{"id":"10.13039\/501100000193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["443875\/2018-9"],"award-info":[{"award-number":["443875\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["5125\/2017"],"award-info":[{"award-number":["5125\/2017"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Zika virus (ZIKV), an emerging virus belonging to the Flaviviridae family, causes severe neurological clinical complications and has been associated with Guillain-Barr\u00e9 syndrome, fetal abnormalities known collectively as congenital Zika syndrome, and microcephaly. Studies have shown that ZIKV infection can alter cellular metabolism, directly affecting neural development. Brain growth requires controlled cellular metabolism, which is essential for cell proliferation and maturation. However, little is known regarding the metabolic profile of ZIKV-infected newborns and possible associations related to microcephaly. Furthering the understanding surrounding underlying mechanisms is essential to developing personalized treatments for affected individuals. Thus, metabolomics, the study of the metabolites produced by or modified in an organism, constitutes a valuable approach in the study of complex diseases. Here, 26 serum samples from ZIKV-positive newborns with or without microcephaly, as well as controls, were analyzed using an untargeted metabolomics approach involving gas chromatography\u2013mass spectrometry (GC-MS). Significant alterations in essential and non-essential amino acids, as well as carbohydrates (including aldohexoses, such as glucose or mannose) and their derivatives (urea and pyruvic acid), were observed in the metabolic profiles analyzed. Our results provide insight into relevant metabolic processes in patients with ZIKV and microcephaly.<\/jats:p>","DOI":"10.3390\/pathogens10040468","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T05:31:37Z","timestamp":1618291897000},"page":"468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection"],"prefix":"10.3390","volume":"10","author":[{"given":"Est\u00e9fane da C.","family":"Nunes","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica, Instituto de Qu\u00edmica, Universidade Federal da Bahia, Rua Barao de Jeremoabo, 147, Salvador, BA 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M. B. de","family":"Filippis","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Flaviv\u00edrus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiane do E. S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica, Instituto de Qu\u00edmica, Universidade Federal da Bahia, Rua Barao de Jeremoabo, 147, Salvador, BA 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieli R. da C.","family":"Faria","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Flaviv\u00edrus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-144X","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Salgado","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Celular e Molecular, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleiton S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto Gon\u00e7alo Moniz, Fiocruz, Rua Waldemar Falc\u00e3o, 121, Salvador, BA 40295-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa C. P. X.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Maternidade de Refer\u00eancia Professor Jos\u00e9 Maria de Magalh\u00e3es Neto, SESAB, Rua Marqu\u00eas de Maric\u00e1, Salvador, BA 40310-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan I.","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Maternidade de Refer\u00eancia Professor Jos\u00e9 Maria de Magalh\u00e3es Neto, SESAB, Rua Marqu\u00eas de Maric\u00e1, Salvador, BA 40310-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via L. L.","family":"Chalhoub","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Flaviv\u00edrus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Brown","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Flaviv\u00edrus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-7326","authenticated-orcid":false,"given":"Marta","family":"Giovanetti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Flaviv\u00edrus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil"},{"name":"Laborat\u00f3rio de Gen\u00e9tica Celular e Molecular, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-9931","authenticated-orcid":false,"given":"Luiz C. J.","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Flaviv\u00edrus, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil"},{"name":"Laborat\u00f3rio de Gen\u00e9tica Celular e Molecular, Universidade Federal de Minas Gerais, Avenida Presidente Ant\u00f4nio Carlos, 6627, Belo Horizonte, MG 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-9036","authenticated-orcid":false,"given":"Fernanda K.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Instituto Multidisciplinar em Sa\u00fade, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Vit\u00f3ria da Conquista, BA 45029-094, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-4099","authenticated-orcid":false,"given":"Isadora C.","family":"de Siqueira","sequence":"additional","affiliation":[{"name":"Instituto Gon\u00e7alo Moniz, Fiocruz, Rua Waldemar Falc\u00e3o, 121, Salvador, BA 40295-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-3705","authenticated-orcid":false,"given":"Gisele A. 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