{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:41:14Z","timestamp":1789382474859,"version":"build-2803163510"},"reference-count":106,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Government (Ministerio de Econom\u00eda y Competitividad)","award":["AGL2017-84165-C2-2-R"],"award-info":[{"award-number":["AGL2017-84165-C2-2-R"]}]},{"name":"Valencian Government","award":["APOSTD\/2017\/037"],"award-info":[{"award-number":["APOSTD\/2017\/037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Rotavirus is the leading cause of severe acute childhood gastroenteritis, responsible for more than 128,500 deaths per year, mainly in low-income countries. Although the mortality rate has dropped significantly since the introduction of the first vaccines around 2006, an estimated 83,158 deaths are still preventable. The two main vaccines currently deployed, Rotarix and RotaTeq, both live oral vaccines, have been shown to be less effective in developing countries. In addition, they have been associated with a slight risk of intussusception, and the need for cold chain maintenance limits the accessibility of these vaccines to certain areas, leaving 65% of children worldwide unvaccinated and therefore unprotected. Against this backdrop, here we review the main vaccines under development and the state of the art on potential alternatives.<\/jats:p>","DOI":"10.3390\/pathogens10050520","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T06:19:11Z","timestamp":1619504351000},"page":"520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The Rotavirus Vaccine Landscape, an Update"],"prefix":"10.3390","volume":"10","author":[{"given":"Roberto","family":"C\u00e1rcamo-Calvo","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Iba\u00f1ez 17, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Iba\u00f1ez 17, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-3428","authenticated-orcid":false,"given":"Javier","family":"Buesa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Iba\u00f1ez 17, 46010 Valencia, Spain"},{"name":"Instituto de Investigacio\u0301n INCLIVA, Hospital Cli\u0301nico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9698-7684","authenticated-orcid":false,"given":"Jes\u00fas","family":"Rodr\u00edguez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Iba\u00f1ez 17, 46010 Valencia, Spain"},{"name":"Instituto de Investigacio\u0301n INCLIVA, Hospital Cli\u0301nico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-3800","authenticated-orcid":false,"given":"Roberto","family":"Gozalbo-Rovira","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Iba\u00f1ez 17, 46010 Valencia, Spain"},{"name":"Instituto de Investigacio\u0301n INCLIVA, Hospital Cli\u0301nico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3201\/eid1202.050006","article-title":"Rotavirus and severe childhood diarrhea","volume":"12","author":"Parashar","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.gastrohep.2011.09.003","article-title":"Vacunas antirrotavirus. Un largo y dif\u00edcil camino","volume":"34","year":"2011","journal-title":"Gastroenterol. 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