{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:00:23Z","timestamp":1760234423087,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The increasing rates of maternal and congenital syphilis (CS) infections are public health concerns and need further investigation in order to provide better assistance in epidemiological surveillance and new strategies for the assistance and prevention of CS. In December 2011, the Brazilian Ministry of Health (BMH) implemented ordinance number 3.242, reinforced in 2012 by ordinance number 77, aiming to improve the quality of the syphilis diagnosis system using rapid tests. Here, we evaluate the incidence, lethality, and possible factors associated with CS in Salvador, Bahia, in the pre-resolution period (2007 to 2011) and post-resolution (2012 to 2016). An observational, ecological time-series study is conducted using secondary data collected from the National Notifiable Diseases Information System (SINAN). Linear regression analysis to estimate increases or reductions in the mean incidence over time is also performed. A total of 5470 CS cases are analyzed. The incidence ranges from 2.1 cases per 1000 live births in 2007 to 17.1 cases per 1000 live births in 2019, showing a progressive increase in incidence over the years and reduction of lethality in the post-resolution period. The number of CS cases reported prior to the implementation of the ordinances (2007\u20132011) does not reveal a significant increase in the incidence. However, in the post-ordinances period (2012\u20132019), there is an average increase of the number of CS cases by three times over the years, with an average increase of 1.8 new cases annually. Our findings highlight the importance of diagnosis and support information in strategies for CS prevention. Furthermore, these data show a positive impact of resolutions on the diagnosis and evolution of the disease.<\/jats:p>","DOI":"10.3390\/pathogens10050606","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T02:31:34Z","timestamp":1621218694000},"page":"606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Incidence of Congenital Syphilis after Implementation of the Brazilian Ministry of Health Ordinances Related to Maternal Diagnostics"],"prefix":"10.3390","volume":"10","author":[{"given":"\u00cdtala Santos","family":"Veras","sequence":"first","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador, Bahia 40290-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Alves","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador, Bahia 40290-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e2ncio Jos\u00e9","family":"de Souza","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador, Bahia 40290-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila Carvalho","family":"Campos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia e Biologia Molecular, Instituto Gon\u00e7alo Moniz, Fiocruz, Bahia 40296-710, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-6722","authenticated-orcid":false,"given":"Galileu","family":"Barbosa Costa","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lise em Sa\u00fade e Vigil\u00e2ncia de Doen\u00e7as n\u00e3o Transmiss\u00edveis, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Minist\u00e9rio da Sa\u00fade, Bras\u00edlia, Federal District 70723-040, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Matos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica, Salvador, Bahia 40290-000, Brazil"},{"name":"Laborat\u00f3rio de Patologia e Biologia Molecular, Instituto Gon\u00e7alo Moniz, Fiocruz, Bahia 40296-710, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Korenromp, E.L., Rowley, J., Alonso, M., Mello, M.B., Wijesooriya, N.S., Mahian\u00e9, S.G., Ishikawa, N., Le, L.V., Newman-Owiredu, M., and Nagelkerke, N. 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