{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:43:45Z","timestamp":1782168225899,"version":"3.54.5"},"reference-count":92,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005908","name":"Bundesministerium f\u00fcr Ern\u00e4hrung und Landwirtschaft","doi-asserted-by":"publisher","award":["2817701614"],"award-info":[{"award-number":["2817701614"]}],"id":[{"id":"10.13039\/501100005908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase (AmpC) producing Enterobacteriaceae occur frequently in livestock animals and the subsequent stages of the meat production chain and are therefore considered a risk for human health. Strict biosecurity measures and optimal farm management should reduce or even prevent poultry flock colonization at farm level. This review summarizes and evaluates published information on the effectiveness of specific intervention measures and farm management factors aiming to reduce the occurrence and spread of ESBL\/AmpC producing or commensal or pathogenic E. coli in broiler chicken farms. In this systematic literature review, a total of 643 publications were analyzed, and 14 studies with significant outcome about the effectiveness of specific measures against E. coli and ESBL\/AmpC producing E. coli in broiler chicken farms were found. Different feed additives seem to have an impact on the occurrence of those microorganisms. The measures \u2018cleaning and disinfection\u2019 and \u2018competitive exclusion\u2019 showed strong effects in prevention in some studies. In summary, some intervention measures showed potential to protect against or eliminate ESBL\/AmpC-producing, commensal or pathogenic E. coli at farm level. Due to the high variability in the outcome of the studies, more specific, detailed investigations are needed to assess the potential of the individual intervention measures.<\/jats:p>","DOI":"10.3390\/pathogens10050608","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T02:31:34Z","timestamp":1621218694000},"page":"608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Are There Effective Intervention Measures in Broiler Production against the ESBL\/AmpC Producer Escherichia coli?"],"prefix":"10.3390","volume":"10","author":[{"given":"Evelyne","family":"Becker","sequence":"first","affiliation":[{"name":"Department for Biological Safety, German Federal Institute for Risk Assessment, 12277 Berlin, Germany"},{"name":"Institute of Pharmacy\/LPG, Pharmaceutical Biology, Universit\u00e4t Greifswald, 17489 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-3561","authenticated-orcid":false,"given":"Michaela","family":"Projahn","sequence":"additional","affiliation":[{"name":"Department for Biological Safety, German Federal Institute for Risk Assessment, 12277 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Burow","sequence":"additional","affiliation":[{"name":"Department for Biological Safety, German Federal Institute for Risk Assessment, 12277 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-2713","authenticated-orcid":false,"given":"Annemarie","family":"K\u00e4sbohrer","sequence":"additional","affiliation":[{"name":"Department for Biological Safety, German Federal Institute for Risk Assessment, 12277 Berlin, Germany"},{"name":"Unit of Veterinary Public Health and Epidemiology, University of Veterinary Medicine Vienna, 1210 Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020). 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