{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:53:42Z","timestamp":1765608822885,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The recent viral pandemic in Wuhan, Hubei, China has led to the identification of a new species of beta-coronavirus, able to infect humans, the 2019-nCoV, later named SARS-CoV-2. SARS-CoV-2 causes a clinical syndrome named COVID-19, which presents with a spectrum of symptoms ranging from mild upper respiratory tract infection to severe pneumonia, with acute respiratory distress syndrome and frequent death. All age groups are susceptible to the infection, but children, especially infants, seem to be partially spared, having a more favorable clinical course than other age groups. There is currently no clear evidence showing vertical transmission and intrauterine SARS-CoV-2 infection in fetuses of women developing COVID-19 pneumonia in late pregnancy, and even if transmission is possible, the SARS-CoV2 positivity of the mother does not require delivery by caesarean section, does not contraindicate the management of the infant in rooming-in and allows breastfeeding. This review provides an overview on the biology of the virus, on the pathogenesis of the infection, with particular attention to pregnancy and neonatal age, on the clinical presentation of infection in newborns and young infants and summarizes the international recommendations currently available on the clinical care of neonates with SARS-CoV2 infection or at risk of catching the virus. The main objective of the review is to provide an update especially focused to the clinical management of COVID-19 infection in the perinatal and neonatal age.<\/jats:p>","DOI":"10.3390\/pathogens10050611","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T04:25:07Z","timestamp":1621225507000},"page":"611","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neonatal SARS-CoV-2 Infection: Practical Tips"],"prefix":"10.3390","volume":"10","author":[{"given":"Cinzia","family":"Auriti","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus, Newborn and Infant\u2014\u201cBambino Ges\u00f9\u201d Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9076-9838","authenticated-orcid":false,"given":"Domenico","family":"De Rose","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus, Newborn and Infant\u2014\u201cBambino Ges\u00f9\u201d Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8473-6861","authenticated-orcid":false,"given":"Vito","family":"Mond\u00ec","sequence":"additional","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit, Policlinico Casilino Hospital, 00169 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Stolfi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Policlinico Umberto I, \u201cSapienza\u201d University, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chryssoula","family":"Tzialla","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit and Neonatal pathology Unit, Policlinico San Matteo IRCCS Foundation, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Study Group of Neonatal Infectious Diseases","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-virology-110615-042301","article-title":"Structure, function, and evolution of coronavirus spike proteins","volume":"3","author":"Li","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tim.2016.03.003","article-title":"Epidemiology, genetic recombination, and pathogenesis of coronaviruses","volume":"24","author":"Su","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Setti, L., Passarini, F., De Gennaro, G., Barbieri, P., Perrone, M.G., Borelli, M., Palmisani, J., Di Gilio, A., Piscitelli, P., and Miani, A. (2020). Airborne transmission route of COVID-19: Why 2 meters\/6 feet of inter-personal distance could not be enough. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082932"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Amodio, E., Vitale, F., Cimino, L., Casuccio, A., and Tramuto, F. (2020). Outbreak of novel coronavirus (SARS-Cov-2): First evidences from international scientific literature and pending questions. Healthcare, 8.","DOI":"10.3390\/healthcare8010051"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/gutjnl-2020-320953","article-title":"Digestive system is a potential route of COVID-19: An analysis of single-cell coexpression pattern of key proteins in viral entry process","volume":"69","author":"Zhang","year":"2020","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"166725","DOI":"10.1016\/j.jmb.2020.11.024","article-title":"Structural insights into SARS-CoV-2 proteins","volume":"433","author":"Arya","year":"2021","journal-title":"J. Mol. Biol."},{"key":"ref_8","first-page":"3","article-title":"Properties of coronavirus and SARS-CoV-2","volume":"42","author":"Malik","year":"2020","journal-title":"Malays. J. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/molehr\/gaaa030","article-title":"Potential influence of COVID-19\/ACE2 on the female reproductive system","volume":"26","author":"Jing","year":"2020","journal-title":"Mol. Hum. Reprod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3201\/eid1401.070667","article-title":"Pandemic influenza and pregnant women","volume":"14","author":"Rasmussen","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.placenta.2005.02.015","article-title":"Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies","volume":"27","author":"Neves","year":"2006","journal-title":"Placenta"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"382-e1","DOI":"10.1016\/j.ajog.2020.10.020","article-title":"Coronavirus disease 2019 infection and placental histopathology in women delivering at term","volume":"224","author":"Patberg","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ajog.2020.05.023","article-title":"Visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy","volume":"223","author":"Algarroba","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"920","DOI":"10.5858\/arpa.2020-0211-SA","article-title":"Infections in pregnancy with COVID-19 and other respiratory RNA virus diseases are rarely, if ever, transmitted to the fetus: Experiences with coronaviruses, parainfluenza, metapneumovirus respiratory syncytial virus, and influenza","volume":"144","author":"Schwartz","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/uog.22088","article-title":"Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: Systematic review","volume":"56","author":"Juan","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_17","unstructured":"Crovetto, F., Crispi, F., Llurba, E., Pascal, R., Larroya, M., Trilla, C., Camacho, M., Medina, C., Doba\u00f1o, C., and Gomez-Roig, M.D. (2021). KidsCorona pregnancy COVID-19 group. Impact of SARS-CoV-2 infection on pregnancy outcomes: A population-based study. Clin. Infect. Dis., ciab104."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Li, M., Chen, L., Zhang, J., Xiong, C., and Li, X. (2020). The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLoS ONE, 15.","DOI":"10.1101\/2020.02.27.967760"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1038\/s41467-020-17436-6","article-title":"Transplacental transmission of SARS-CoV-2 infection","volume":"11","author":"Vivanti","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_20","first-page":"1846","article-title":"Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn","volume":"323","author":"Dong","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"ref_21","first-page":"1848","article-title":"Antibodies in Infants Born to Mothers With COVID-19 Pneumonia","volume":"323","author":"Zeng","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1038\/s41467-020-18982-9","article-title":"Synthesis and systematic review of reported neonatal SARS-CoV-2 infections","volume":"11","author":"Raschetti","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_23","unstructured":"WHO COVID-19 LENS (Living Evidence Synthesis) Working Group (2021, March 29). Definition and Categorization of the Timing of Mother-To-Child Transmission of SARS-CoV-2. Available online: www.who.int\/publications\/i\/item\/WHO-2019-nCoV-mother-to-child-transmission-2021.1."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Hopwood, A.J., Jordan-Villegas, A., Gutierrez, L.D., Cowart, M.C., Vega-Montalvo, W., Cheung, W.L., McMahan, M.J., Gomez, M.R., and Laham, F.R. (2020). Severe acute respiratory syndrome coronavirus-2 pneumonia in a newborn treated with remdesivir and coronavirus disease 2019 convalescent plasma. J. Pediatr. Infect. Dis. Soc.","DOI":"10.1093\/jpids\/piaa165"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s12519-020-00345-5","article-title":"Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus","volume":"16","author":"Chen","year":"2020","journal-title":"World J. Pediatr."},{"key":"ref_26","unstructured":"Italian National Institute of Health (2021, March 29). COVID-19: National Update 24 March 2021 (Italian Version). Available online: www.epicentro.iss.it\/coronavirus\/bollettino\/Bollettino-sorveglianza-integrata-COVID-19_24-marzo-2021.pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13052-020-0820-x","article-title":"Novel Coronavirus disease (COVID-19) in newborns and infants: What we know so far","volume":"46","author":"Piersigilli","year":"2020","journal-title":"Ital. J. Pediatr."},{"key":"ref_28","unstructured":"Italian Ministry of Health and Italian National Institute of Health (2021, March 29). Laboratory Tests for SARS-CoV-2 and Their Use in Public Health (Italian Version: Test di Laboratorio per SARS-CoV-2 e Loro Uso in Sanit\u00e0 Pubblica). Available online: www.iss.it\/documents\/20126\/0\/COVID+19_+test+v4k_last.pdf\/9ab1f211-7d88-bcb1-d454-cfed04aa8b05?t=1604483686312."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1055\/s-0040-1712457","article-title":"Vertical transmission of SARS-CoV-2: What is the optimal definition?","volume":"37","author":"Blumberg","year":"2020","journal-title":"Am. J. Perinatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.21037\/atm.2020.02.20","article-title":"Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection","volume":"8","author":"Wang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Poorisrisak, P., Bivolarova, M.P., Bek\u00f6, G., Heiring, C., Clausen, G., and Greisen, G. (2020). Aerosol generation by respiratory support of neonates may be low. J. Pediatric. Infect. Dis. Soc.","DOI":"10.1111\/apa.15704"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e366","DOI":"10.1016\/S2214-109X(20)30484-8","article-title":"Inclusion of pregnant women in COVID-19 treatment trials: A review and global call to action","volume":"9","author":"Taylor","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1097\/INF.0000000000003081","article-title":"Neonates with SARS-CoV-2 infection and pulmonary disease safely treated with remdesivir","volume":"40","author":"Saikia","year":"2021","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e20201701","DOI":"10.1542\/peds.2020-1701","article-title":"Infant with SARS-CoV-2 infection causing severe lung disease treated with remdesivir","volume":"146","author":"Frauenfelder","year":"2020","journal-title":"Pediatrics"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/jpids\/piaa084","article-title":"Severe acute respiratory syndrome Coronavirus 2 infection in febrile neonates","volume":"9","author":"Wardell","year":"2020","journal-title":"J. Pediatric Infect. Dis. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/jth.15216","article-title":"SARS-COV-2-associated coagulopathy and thromboembolism prophylaxis in children: A single-center observational study","volume":"19","author":"Giraudo","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1111\/jth.15073","article-title":"Pediatric\/neonatal hemostasis and thrombosis subcommittee of the ISTH SSC. Consensus-based clinical recommendations and research priorities for anticoagulant thromboprophylaxis in children hospitalized for COVID-19-related illness","volume":"18","author":"Goldenberg","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13052-020-00900-w","article-title":"Italian SITIP-SIP SARS-Cov-2 pediatric infection study group. Treatment of children with COVID-19: Position paper of the Italian Society of Pediatric Infectious Disease","volume":"46","author":"Venturini","year":"2020","journal-title":"Ital. J. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1002\/art.41616","article-title":"American college of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: Version 2","volume":"73","author":"Henderson","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S2352-4642(20)30177-2","article-title":"COVID-19 in children and adolescents in Europe: A multinational, multicentre cohort study","volume":"4","author":"Lanaspa","year":"2020","journal-title":"Lancet Child. Adolesc. Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/bfm.2020.0095","article-title":"Managing COVID-19-Positive Maternal-Infant Dyads: An Italian Experience","volume":"15","author":"Salvatori","year":"2020","journal-title":"Breastfeed. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e13032","DOI":"10.1111\/mcn.13032","article-title":"SARS-CoV-2 and human milk: What is the evidence?","volume":"2020 16","author":"Lackey","year":"2020","journal-title":"Matern Child Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/S0140-6736(20)31181-8","article-title":"Detection of SARS-CoV-2 in human breastmilk","volume":"395","author":"Conzelmann","year":"2020","journal-title":"Lancet"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"661806","DOI":"10.3389\/fimmu.2021.661806","article-title":"Breastfeeding and COVID-19: From nutrition to immunity","volume":"12","author":"Vassilopoulou","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e13010","DOI":"10.1111\/mcn.13010","article-title":"Breastfeeding and coronavirus disease-2019: Ad interim indications of the Italian Society of Neonatology endorsed by the Union of European Neonatal & Perinatal Societies","volume":"16","author":"Davanzo","year":"2020","journal-title":"Matern Child. Nutr."},{"key":"ref_46","unstructured":"Centers for Disease Control and Prevention (2021, April 01). Interim Guidance on Breastfeeding and Breast Milk Feeds in the Context of COVID-19, Available online: www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/care-for-breastfeeding-women.html."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e03192-20","DOI":"10.1128\/mBio.03192-20","article-title":"Characterization of SARS-CoV-2 RNA, antibodies, and neutralizing capacity in milk produced by women with COVID-19","volume":"12","author":"Pace","year":"2021","journal-title":"Mbio"},{"key":"ref_48","unstructured":"Centers for Disease Control and Prevention (2021, April 01). COVID-19\u2014Evaluation and Management Considerations for Neonates at Risk for COVID-19 (Updated on 8 December 2020), Available online: www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/caring-for-newborns.html."},{"key":"ref_49","unstructured":"Italian National Institute of Health (2021, April 01). Interim Guidance on Pregnancy, Childbirth, Breastfeeding and Care of Infants (0\u20132 Years) in Response to the COVID-19 Emergency. (Version of 5 February 2021). Available online: https:\/\/www.iss.it\/documents\/5430402\/0\/Rapporto+ISS+COVID-19+2_2021_EN.pdf\/421a0bc6-1933-aa77-6b39-a7860d866a16?t=1615472502820."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1055\/s-0040-1709688","article-title":"Neonatal resuscitation and postresuscitation care of infants born to mothers with suspected or confirmed SARS-CoV-2 infection","volume":"37","author":"Chandrasekharan","year":"2020","journal-title":"Am. J. Perinatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"151320","DOI":"10.1016\/j.semperi.2020.151320","article-title":"Infection prevention and control for labor and delivery, well baby nurseries, and neonatal intensive care units","volume":"44","author":"Saiman","year":"2020","journal-title":"Semin. Perinatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41390-020-0937-z","article-title":"Neonatal emergency transport system during COVID-19 pandemic in the Veneto Region: Proposal for standard operating procedures","volume":"89","author":"Cavicchiolo","year":"2021","journal-title":"Pediatr. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Terheggen, U., Heiring, C., Kjellberg, M., Hegardt, F., Kneyber, M., Gente, M., Roehr, C.C., Jourdain, G., Tissieres, P., and Ramnarayan, P. (2020). European consensus recommendations for neonatal and paediatric retrievals of positive or suspected COVID-19 patients. Pediatr. Res.","DOI":"10.1038\/s41390-020-1050-z"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","article-title":"Virological assessment of hospitalized patients with COVID-2019","volume":"581","author":"Corman","year":"2020","journal-title":"Nature"},{"key":"ref_55","unstructured":"Centers for Disease Control and Prevention (2021, April 01). COVID-19\u2014Testing Overview: Updated on 17 March 2021, Available online: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/testing-overview.html."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1542\/peds.2015-0699","article-title":"Committee on fetus and newborn, American Academy of Pediatrics.; et al. Hospital stay for healthy term newborn infants","volume":"135","author":"Benitz","year":"2015","journal-title":"Pediatrics"},{"key":"ref_57","unstructured":"Centers for Disease Control and Prevention (2021, April 01). COVID-19\u2014Guidance for Fully Vaccinated People: Updated on 8 March 2021, Available online: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/fully-vaccinated-guidance.html."},{"key":"ref_58","unstructured":"The New York Times (2021, April 01). The Pfizer-BioNTech Vaccine Is Said to Be Powerfully Protective in Adolescents. Available online: www.nytimes.com\/2021\/03\/31\/health\/pfizer-biontech-vaccine-adolescents.html."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Gray, K.J., Bordt, E.A., Atyeo, C., Deriso, E., Akinwunmi, B., Young, N., Medina Baez, A., Shook, L.L., Cvrk, D., and James, K. (2021). COVID-19 vaccine response in pregnant and lactating women: A cohort study. Am. J. Obstet. Gynecol., 187\u2013193.","DOI":"10.1101\/2021.03.07.21253094"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/5\/611\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:02:27Z","timestamp":1760162547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/5\/611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":59,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["pathogens10050611"],"URL":"https:\/\/doi.org\/10.3390\/pathogens10050611","relation":{},"ISSN":["2076-0817"],"issn-type":[{"type":"electronic","value":"2076-0817"}],"subject":[],"published":{"date-parts":[[2021,5,17]]}}}