{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:29:36Z","timestamp":1793276976308,"version":"4.5.0"},"reference-count":18,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["DZIF TI 07.001"],"award-info":[{"award-number":["DZIF TI 07.001"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2019: EKFS10"],"award-info":[{"award-number":["2019: EKFS10"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background: Neuralgic amyotrophy (NA) has been described as a possible extrahepatic manifestation of hepatitis E virus (HEV) infection. Usually, HEV-associated NA occurs bilaterally. The clinical characteristics determining the course of HEV-associated NA have still not been defined. Methods: In this retrospective multicentric case series, 16 patients with HEV-associated NA were studied and compared to 176 HEV patients without NA in terms of their age, sex, and ALT levels. Results: Neither gender distribution (75% vs. 67% male) nor age (47 vs. 48 years median) differed significantly between the NA patients and controls. Eight NA patients (50%) presented with bilateral involvement\u2014seven of these had right-side dominance and one had left-side dominance. Thirteen cases (81%) were hospitalized. Eight of these patients stayed in hospital for five to seven days, and five patients stayed for up to two weeks. The time from the onset of NA to the HEV diagnosis, as well as the diagnostic and therapeutic proceedings, showed a large variability. In total, 13 (81%) patients received treatment: 1\/13 (8%) received intravenous immunoglobulins, 8\/13 (62%) received glucocorticoids, 3\/13 (23%) received ribavirin, and 6\/13 (46%) received pregabalin\/gabapentin. Patients with ages above the median (47 years) were more likely to be treated (p = 0.001). Conclusion: HEV-associated NA causes a relevant morbidity. In our case series neither the type of treatment nor the time of initiation of therapy had a significant effect on the duration of hospitalization or the course of the disease. The clinical presentation, the common diagnostic and therapeutic procedures, and the patients\u2019 characteristics showed large variability, demonstrating the necessity of standardized protocols for this rare but relevant disease.<\/jats:p>","DOI":"10.3390\/pathogens10060672","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T01:51:37Z","timestamp":1622425897000},"page":"672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["HEV-Associated Neuralgic Amyotrophy: A Multicentric Case Series"],"prefix":"10.3390","volume":"10","author":[{"given":"Johannes H.","family":"Bannasch","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"Department of Medicine, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-Borstel and Heidelberg Partner Sites, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-8880","authenticated-orcid":false,"given":"Benjamin","family":"Berger","sequence":"additional","affiliation":[{"name":"Clinic of Neurology and Neurophysiology, Medical Centre\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus-Peter","family":"Schwartkop","sequence":"additional","affiliation":[{"name":"Clinic for Neurology, Medical Centre Itzehoe, 25524 Itzehoe, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Berning","sequence":"additional","affiliation":[{"name":"Department of Medicine I, University Medical Center Dresden, Technische Universit\u00e4t (TU) Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2860-0270","authenticated-orcid":false,"given":"Oliver","family":"Goetze","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Department of Medicine II, University Hospital Wurzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Panning","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Fritz-Weltin","sequence":"additional","affiliation":[{"name":"Clinic of Neurology and Neurophysiology, Medical Centre\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Trendelenburg","sequence":"additional","affiliation":[{"name":"Clinic for Neurology, Medical Centre Itzehoe, 25524 Itzehoe, Germany"},{"name":"Department of Neurology, University Medical Centre G\u00f6ttingen, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Gelderblom","sequence":"additional","affiliation":[{"name":"Clinic for Neurology, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"L\u00fctgehetmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-Borstel and Heidelberg Partner Sites, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridrike","family":"Stute","sequence":"additional","affiliation":[{"name":"Clinic for Pediatrics, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-4476","authenticated-orcid":false,"given":"Thomas","family":"Horvatits","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-Borstel and Heidelberg Partner Sites, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Dirks","sequence":"additional","affiliation":[{"name":"Clinic for Neurology and Neurophysiology, Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Behrendt","sequence":"additional","affiliation":[{"name":"Department for Gastroenterology, Hepatology und Endocrinology, Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Pischke","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"German Center for Infection Research (DZIF), Hamburg-L\u00fcbeck-Borstel and Heidelberg Partner Sites, 20359 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jhep.2016.11.016","article-title":"Hepatitis E virus: Infection beyond the liver?","volume":"66","author":"Pischke","year":"2017","journal-title":"J. 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