{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:05:06Z","timestamp":1760234706368,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010096","name":"Secretar\u00eda de Educaci\u00f3n P\u00fablica","doi-asserted-by":"publisher","award":["DSA\/103.5\/14\/11311M"],"award-info":[{"award-number":["DSA\/103.5\/14\/11311M"]}],"id":[{"id":"10.13039\/100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>We determined the association between T. gondii infection and suicidal behavior in people with alcohol consumption. One-thousand four-hundred and twenty-three people with alcohol consumption were screened for suicidal behavior and tested for anti-T. gondii IgG and IgM antibodies using commercially available enzyme-linked immunosorbent assays. Anti-T. gondii IgG antibodies were found in 34 of 224 (15.2%) individuals with suicidal ideation and in 118 (9.8%) of 1199 individuals without suicidal ideation (OR: 1.63; 95% CI: 1.08\u20132.47; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 2.24; 95% CI: 1.33\u20133.78; p = 0.001) and in individuals aged \u226430 years (OR: 2.68; 95% CI: 1.22\u20135.87; p = 0.01) and &gt;50 years (OR: 2.85; 95% CI: 1.19\u20136.77; p = 0.01). Anti-T. gondii IgG antibodies were found in 17 of 136 (12.5%) individuals with suicide attempts and in 135 (10.5%) of 1287 individuals without suicide attempts (OR: 1.21; 95% CI: 0.71\u20132.08; p = 0.47). Seroprevalence of T. gondii infection was associated with suicide attempts in women (OR: 1.88; 95% CI: 0.99\u20133.55; p = 0.04). No association between anti-T. gondii IgM and suicidal ideation or suicide attempts was found. Results suggest that T. gondii infection is associated with suicidal behavior in people with alcohol consumption.<\/jats:p>","DOI":"10.3390\/pathogens10060734","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T13:31:39Z","timestamp":1623331899000},"page":"734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Toxoplasma gondii Infection and Suicidal Behavior in People with Alcohol Consumption"],"prefix":"10.3390","volume":"10","author":[{"given":"Cosme","family":"Alvarado-Esquivel","sequence":"first","affiliation":[{"name":"Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Ju\u00e1rez University of Durango State, Avenida Universidad S\/N, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Estrada-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Institute for Scientific Research \u201cDr. Roberto Rivera-Damm\u201d, Ju\u00e1rez University of Durango State, Avenida Universidad S\/N, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma Rosa","family":"P\u00e9rez-\u00c1lamos","sequence":"additional","affiliation":[{"name":"Institute for Scientific Research \u201cDr. Roberto Rivera-Damm\u201d, Ju\u00e1rez University of Durango State, Avenida Universidad S\/N, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Beristain-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Facultad de Enfermer\u00eda y Obstetricia, Ju\u00e1rez University of Durango State, Blvd. Juan Pablo II 512, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel Osvaldo","family":"Alvarado-F\u00e9lix","sequence":"additional","affiliation":[{"name":"Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Ju\u00e1rez University of Durango State, Avenida Universidad S\/N, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Alexis","family":"Alvarado-F\u00e9lix","sequence":"additional","affiliation":[{"name":"Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Ju\u00e1rez University of Durango State, Avenida Universidad S\/N, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Sifuentes-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Ju\u00e1rez University of Durango State, Avenida Universidad S\/N, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e015719","DOI":"10.1590\/s1984-29612019106","article-title":"Toxoplasma gondii in cattle in Brazil: A review","volume":"29","author":"Gomes","year":"2020","journal-title":"Rev. Bras. Parasitol. Vet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"109145","DOI":"10.1016\/j.vetpar.2020.109145","article-title":"All about toxoplasmosis in cats: The last decade","volume":"283","author":"Dubey","year":"2020","journal-title":"Vet. Parasitol."},{"key":"ref_3","first-page":"435","article-title":"Toxoplasmosis in Germany","volume":"116","author":"Pleyer","year":"2019","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/00325481.2019.1568792","article-title":"High burden and low awareness of toxoplasmosis in the United States","volume":"131","author":"Connolly","year":"2019","journal-title":"Postgrad. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.parint.2018.07.004","article-title":"Congenital toxoplasmosis: An overview of the neurological and ocular manifestations","volume":"67","author":"Khan","year":"2018","journal-title":"Parasitol. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.jfo.2020.01.001","article-title":"Toxoplasmosis and behavioural changes","volume":"43","author":"Desmettre","year":"2020","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.schres.2011.10.026","article-title":"Infectious agents associated with schizophrenia: A meta-analysis","volume":"136","author":"Arias","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.parint.2010.12.003","article-title":"Toxoplasma gondii infection and schizophrenia: A case control study in a low Toxoplasma seroprevalence Mexican population","volume":"60","author":"Liesenfeld","year":"2011","journal-title":"Parasitol. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.14740\/jocmr2576w","article-title":"Toxoplasma gondii Infection and Mixed Anxiety and Depressive Disorder: A Case-Control Seroprevalence Study in Durango, Mexico","volume":"8","author":"Beristain","year":"2016","journal-title":"J. Clin. Med. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3389\/fpsyt.2019.01012","article-title":"Negative Effects of Latent Toxoplasmosis on Mental Health","volume":"10","author":"Flegr","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s00436-018-6040-2","article-title":"Toxoplasma gondii infection and behavioral outcomes in humans: A systematic review","volume":"117","author":"Martinez","year":"2018","journal-title":"Parasitol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/NMD.0b013e3181c29a23","article-title":"Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders","volume":"197","author":"Arling","year":"2009","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/NMD.0b013e318221416e","article-title":"Toxoplasma gondii seropositivity and suicide rates in women","volume":"199","author":"Ling","year":"2011","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1097\/NMD.0000000000000037","article-title":"Toxoplasma gondii infection and suicide attempts: A case-control study in psychiatric outpatients","volume":"201","author":"Liesenfeld","year":"2013","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/archgenpsychiatry.2012.668","article-title":"Toxoplasma gondii infection and self-directed violence in mothers","volume":"69","author":"Pedersen","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.schres.2011.08.006","article-title":"Toxoplasma gondii antibody titers and history of suicide attempts in patients with schizophrenia","volume":"133","author":"Okusaga","year":"2011","journal-title":"Schizophr. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/2327-6924.12129","article-title":"New findings: Depression, suicide, and Toxoplasma gondii infection","volume":"26","author":"Hsu","year":"2014","journal-title":"J. Am. Assoc. Nurse Pract."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Al\u00e9s, G., Hern\u00e1ndez-Calle, D., Khauli, N., and Keyes, K.M. (2020). Why Are Suicide Rates Increasing in the United States? Towards a Multilevel Reimagination of Suicide Prevention. Curr. Top. Behav. Neurosci., 30.","DOI":"10.1007\/7854_2020_158"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3390\/ijerph7041392","article-title":"Suicidal behavior and alcohol abuse","volume":"7","author":"Pompili","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1176\/appi.ajp.2019.19070673","article-title":"Alcohol Use Disorder and Risk of Suicide in a Swedish Population-Based Cohort","volume":"177","author":"Edwards","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jad.2020.02.024","article-title":"Comorbid alcohol use disorder in psychiatric MDD patients: A five-year prospective study","volume":"267","author":"Holma","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.genhosppsych.2019.06.011","article-title":"Sex differences in binge drinking and suicide attempts in a nationally representative sample","volume":"60","author":"Kittel","year":"2019","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jflm.2017.11.006","article-title":"Alcohol use by suicide victims in the city of Sao Paulo, Brazil, 2011-2015","volume":"53","author":"Ponce","year":"2018","journal-title":"J. Forensic Leg. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1645\/GE-2612.1","article-title":"Seroepidemiology of Toxoplasma gondii infection in general population in a northern Mexican city","volume":"97","author":"Liesenfeld","year":"2011","journal-title":"J. Parasitol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.psychres.2019.06.031","article-title":"Relationship between Toxoplasma gondii seropositivity and depression in children and adolescents","volume":"278","author":"Kandemir","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Alvarado-Esquivel, C., Carrillo-Oropeza, D., Pacheco-Vega, S.J., Hern\u00e1ndez-Tinoco, J., Salcedo-Jaquez, M., S\u00e1nchez-Anguiano, L.F., Ortiz-Jurado, M.N., Alarc\u00f3n-Alvarado, Y., Liesenfeld, O., and Beristain-Garc\u00eda, I. (2015). Toxoplasma gondii exposure in patients suffering from mental and behavioral disorders due to psychoactive substance use. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-0912-1"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gale, S.D., Berrett, A.N., Brown, B., Erickson, L.D., and Hedges, D.W. (2016). No association between current depression and latent toxoplasmosis in adults. Folia Parasitol., 63.","DOI":"10.14411\/fp.2016.032"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.forsciint.2010.02.020","article-title":"May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects?","volume":"199","author":"Yagmur","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/tmi.12933","article-title":"Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients","volume":"22","author":"Farashbandi","year":"2017","journal-title":"Trop. Med. Int. Health"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/6\/734\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:13:00Z","timestamp":1760163180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/6\/734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,10]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["pathogens10060734"],"URL":"https:\/\/doi.org\/10.3390\/pathogens10060734","relation":{},"ISSN":["2076-0817"],"issn-type":[{"type":"electronic","value":"2076-0817"}],"subject":[],"published":{"date-parts":[[2021,6,10]]}}}