{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:32:07Z","timestamp":1777332727008,"version":"3.51.4"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Veterinary Sciences Brno Czech Republic","award":["Ceitec VFU\/Ho\u0159\u00edn\/ITA 2019."],"award-info":[{"award-number":["Ceitec VFU\/Ho\u0159\u00edn\/ITA 2019."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Feline coronavirus (FCoV) is a complex pathogen causing feline infectious peritonitis (FIP). Host genetics represents a factor contributing to the pathogenesis of the disease. Differential susceptibility of various breeds to FIP was reported with controversial results. The objective of this study was to compare the genetic diversity of different breeds on a panel of candidate genes potentially affecting FCoV infection. One hundred thirteen cats of six breeds were genotyped on a panel of sixteen candidate genes. SNP allelic\/haplotype frequencies were calculated; pairwise FST and molecular variance analyses were performed. Principal coordinate (PCoA) and STRUCTURE analyses were used to infer population structure. Interbreed differences in allele frequencies were observed. PCoA analysis performed for all genes of the panel indicated no population substructure. In contrast to the full marker set, PCoA of SNP markers associated with FCoV shedding (NCR1 and SLX4IP) showed three clusters containing only alleles associated with susceptibility to FCoV shedding, homozygotes and heterozygotes for the susceptibility alleles, and all three genotypes, respectively. Each cluster contained cats of multiple breeds. Three clusters of haplotypes were identified by PCoA, two clusters by STRUCTURE. Haplotypes of a single gene (SNX5) differed significantly between the PCoA clusters.<\/jats:p>","DOI":"10.3390\/pathogens10060778","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T13:29:58Z","timestamp":1624282198000},"page":"778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Population Diversity of Candidate Genes for Resistance\/Susceptibility to Coronavirus Infection in Domestic Cats: An Inter-Breed Comparison"],"prefix":"10.3390","volume":"10","author":[{"given":"Jana","family":"Bubenikova","sequence":"first","affiliation":[{"name":"Department of Animal Genetics, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"},{"name":"CEITEC UVS, RG Animal Immunogenomics, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leona","family":"Vychodilova","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Stejskalova","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-879X","authenticated-orcid":false,"given":"Jan","family":"Futas","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"},{"name":"CEITEC UVS, RG Animal Immunogenomics, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3076-4840","authenticated-orcid":false,"given":"Jan","family":"Oppelt","sequence":"additional","affiliation":[{"name":"CEITEC UVS, RG Animal Immunogenomics, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"},{"name":"Department of Pathology and Laboratory Medicine, Division of Neuropathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6100, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4300-8534","authenticated-orcid":false,"given":"Petra","family":"Cerna","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523-1678, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4721-5685","authenticated-orcid":false,"given":"Martin","family":"Plasil","sequence":"additional","affiliation":[{"name":"CEITEC UVS, RG Animal Immunogenomics, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5548-4212","authenticated-orcid":false,"given":"Petr","family":"Horin","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"},{"name":"CEITEC UVS, RG Animal Immunogenomics, University of Veterinary Sciences Brno, 61242 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cvsm.2020.05.002","article-title":"Feline Infectious Peritonitis","volume":"50","author":"Kennedy","year":"2020","journal-title":"Veter. 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