{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:15:02Z","timestamp":1791335702742,"version":"4.3.1"},"reference-count":33,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>This study investigated the causative agent of a haemorrhagic fever epidemic in Gedaref state, south-east Sudan. Six cases of febrile illness with haemorrhagic manifestations presented at outpatient health-clinics. Blood samples were collected from the patients and shipped to Khartoum where they were tested for dengue virus (DENV), chikungunya virus (CHIKV), and Rift Valley fever virus (RVFV) using real-time qPCR. Fifty percent (3\/6) of them tested positive for RVFV and neither DENV or CHIKV was detected. All patients were males between 20 and 48 years old who had no history of recent travel. This finding describes the first emergence of RVFV in Gedaref state. Considering that the state hosts a major market of livestock, and it has one of the largest-seasonal open pastures in the country that is usually flooded with herds from the neighbouring states and countries during the rainy season, this emergence could represent a major threat to public health in the region and countries importing animals and\/or animal products from east Africa. Therefore, we urge the policymakers of the health and animal resources sectors to implement a one health strategy with a well-established early warning surveillance and response system to prevent the establishment of the disease in the area.<\/jats:p>","DOI":"10.3390\/pathogens10070885","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T04:26:06Z","timestamp":1626150366000},"page":"885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Emergence of Rift Valley Fever in Gedaref State Urges the Need for a Cross-Border One Health Strategy and Enforcement of the International Health Regulations"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-9508","authenticated-orcid":false,"given":"Ayman","family":"Ahmed","sequence":"first","affiliation":[{"name":"Institute of Endemic Diseases, University of Khartoum, Khartoum 11111, Sudan"},{"name":"World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77550, USA"},{"name":"Institute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"National Public Health Laboratory, Sudan Federal Ministry of Health, Khartoum 11111, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5701-2561","authenticated-orcid":false,"given":"Mawahib","family":"Eldigail","sequence":"additional","affiliation":[{"name":"National Public Health Laboratory, Sudan Federal Ministry of Health, Khartoum 11111, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Elhassan","sequence":"additional","affiliation":[{"name":"National Public Health Laboratory, Sudan Federal Ministry of Health, Khartoum 11111, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-8556","authenticated-orcid":false,"given":"Scott","family":"Weaver","sequence":"additional","affiliation":[{"name":"World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77550, USA"},{"name":"Institute for Human Infections and Immunity, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.3201\/eid2612.201599","article-title":"Unique Out-break of Rift Valley Fever in Sudan, 2019","volume":"26","author":"Ahmed","year":"2020","journal-title":"Emerg. 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