{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:58:28Z","timestamp":1790402308082,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["2020-3735"],"award-info":[{"award-number":["2020-3735"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The clinical significance of pleural effusion in Mycoplasma pneumoniae (MP) pneumonia in children has not yet been elucidated. Herein, we investigated the clinical implications of pleural effusion in children with MP pneumonia. Overall, 150 children with MP pneumonia transferred to a tertiary hospital were enrolled in this study. Information on their clinical, laboratory, and radiological features was retrospectively obtained from medical chart reviews. In total, 24 (16.0%) children had pleural effusion at the time of admission. The duration of fever and length of hospitalization were significantly longer in the pleural effusion group than in the non-pleural effusion group. A significantly higher proportion of individuals in the pleural effusion group had a poor response to stepwise treatment for MP pneumonia. The mean C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase levels were significantly higher in the pleural effusion group than in the non-pleural effusion group at admission. The prevalence of severe pneumonia, defined on the basis of the extent of pneumonic lesions on chest radiography, was higher in the pleural effusion group than in the non-pleural effusion group. However, there was no significant intergroup difference in the proportion of macrolide-resistant MP cases or respiratory viral coinfections. The presence of pleural effusion in children with MP pneumonia indicated a more severe clinical course and poor treatment response. The results of the present study would help in the creation of a therapeutic plan and prediction of the clinical course of MP pneumonia in children.<\/jats:p>","DOI":"10.3390\/pathogens10091075","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T04:24:27Z","timestamp":1629865467000},"page":"1075","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinical Significance of Pleural Effusion in Mycoplasma pneumoniae Pneumonia in Children"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-7675","authenticated-orcid":false,"given":"Seo-Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Chonnam National University Hospital, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chonnam National University Hospital, Gwangju 61469, Korea"},{"name":"Department of Pediatrics, Chonnam National University Medical School, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-2165","authenticated-orcid":false,"given":"Eun-Song","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chonnam National University Hospital, Gwangju 61469, Korea"},{"name":"Department of Pediatrics, Chonnam National University Medical School, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chonnam National University Hospital, Gwangju 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lee, E., Kim, C.H., Lee, Y.J., Kim, H., Kim, B., Kim, H.Y., Kim, Y., Kim, S., Park, C., and Seo, J. (2020). Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-4810-9"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20073","DOI":"10.2807\/ese.17.05.20073-en","article-title":"Epidemic of Mycoplasma pneumoniae infection in Denmark, 2010 and 2011","volume":"17","author":"Uldum","year":"2012","journal-title":"Eurosurveillance"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37037","DOI":"10.1038\/srep37037","article-title":"Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in school-aged children","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.21037\/apm-19-497","article-title":"An analysis of 20 clinical cases of refractory mycoplasma pneumonia in children","volume":"9","author":"Zhai","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jinf.2008.06.012","article-title":"Methylprednisolone pulse therapy for refractory Mycoplasma pneumoniae pneumonia in children","volume":"57","author":"Tamura","year":"2008","journal-title":"J. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3345\/kjp.2017.60.5.151","article-title":"Prevalence and clinical manifestations of macrolide resistant Mycoplasma pneumoniae pneumonia in Korean children","volume":"60","author":"Lee","year":"2017","journal-title":"Korean J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4168\/aair.2017.9.4.340","article-title":"Macrolide Resistance and Its Impacts on M. Pneumoniae Pneumonia in Children: Comparison of Two Recent Epidemics in Korea","volume":"9","author":"Kim","year":"2017","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1128\/AAC.00663-13","article-title":"Nationwide Surveillance of Macrolide-Resistant Mycoplasma pneumoniae Infection in Pediatric Patients","volume":"57","author":"Kawai","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/adc.78.1.67","article-title":"Analysis of mycoplasmal pleural effusion by the polymerase chain reaction","volume":"78","author":"Narita","year":"1998","journal-title":"Arch. Dis. Child."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jfma.2020.08.018","article-title":"Severe Mycoplasma pneumoniae pneumonia requiring intensive care in children, 2010\u20132019","volume":"120","author":"Lee","year":"2021","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/INF.0b013e31828637b1","article-title":"Etiology of Empyema Thoracis And Parapneumonic Pleural Effusion in Taiwanese Children and Adolescents Younger Than 18 Years of Age","volume":"32","author":"Lin","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_12","first-page":"483","article-title":"Complicated parapneumonic effusion and empyema in children","volume":"39","author":"Shen","year":"2006","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Shuvy, M., Rav-Acha, M., Izhar, U., Ron, M., and Nir-Paz, R. (2006). Massive empyema caused by Mycoplasma pneumoniae in an adult: A case report. BMC Infect. Dis., 6.","DOI":"10.1186\/1471-2334-6-18"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/OAEM.S29942","article-title":"Pleural effusion: Diagnosis, treatment, and management","volume":"4","author":"Karkhanis","year":"2012","journal-title":"Open Access Emerg. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lee, E., and Lee, Y. (2021). Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia. J. Clin. Med., 10.","DOI":"10.3390\/jcm10061154"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jmii.2020.10.002","article-title":"Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children","volume":"54","author":"Tsai","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3389\/fmicb.2016.00974","article-title":"Mycoplasma pneumoniae: Current Knowledge on Macrolide Resistance and Treatment","volume":"7","author":"Pereyre","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3345\/kjp.2018.61.8.258","article-title":"Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia","volume":"61","author":"Jeong","year":"2018","journal-title":"Korean J. Pediatr."},{"key":"ref_19","first-page":"307","article-title":"Evaluation of Seeplex Pneumobacter multiplex PCR kit for the detection of respiratory bacterial pathogens in pediatric patients","volume":"29","author":"Park","year":"2009","journal-title":"Korean J. Lab. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJM197010082831505","article-title":"Frequency of Pleural Effusions in Mycoplasma and Viral Pneumonias","volume":"283","author":"Fine","year":"1970","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Miyashita, N., Sugiu, T., Kawai, Y., Yamaguchi, T., and Ouchi, K. (2009). Radiographic Features of Mycoplasma pneumoniae Pneumonia: Differential Diagnosis and Performance Timing. BMC Med. Imaging, 9.","DOI":"10.1186\/1471-2342-9-7"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/01.inf.0000143655.11695.99","article-title":"Two Distinct Patterns of Pleural Effusions Caused by Mycoplasma pneumoniae Infection","volume":"23","author":"Narita","year":"2004","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-019-1152-5","article-title":"Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: A case control study","volume":"20","author":"Choi","year":"2019","journal-title":"Respir. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.4187\/respcare.03920","article-title":"Lactate Dehydrogenase as a Biomarker for Prediction of Refractory Mycoplasma pneumoniae Pneumonia in Children","volume":"60","author":"Lu","year":"2015","journal-title":"Respir. Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1017\/S0950268818000778","article-title":"Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia","volume":"146","author":"Zhang","year":"2018","journal-title":"Epidemiol. Infect."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Wang, J., Chen, W., Shen, N., Tao, Y., Zhao, R., Luo, L., Li, B., and Cao, Q. (2020). Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia. BMC Infect. 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