{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:35:48Z","timestamp":1786422948354,"version":"build-2736575974"},"reference-count":117,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>The role of purified natural products in the prevention and treatment of countless diseases of bacterial, fungal, and viral origin cannot be overestimated. New antiviral drugs have been obtained from natural sources and transformed into preparations for prophylactic and therapeutic purposes. Flavonoids, polyphenols, saponins, proanthocyanins, polysaccharides, organic acids, proteins, polypeptides, and essential oils derived from plants, animals, or microorganisms can control and combat foodborne viral infections, including hepatitis A. The components of essential oils are characterized by numerous therapeutic and antioxidant properties and exhibit a broad spectrum of antimicrobial and antiviral activity. Due to these properties, they can be used to preserve meat, fruit, vegetables, and their products. Over the past two decades, much effort has been made to identify natural products, mostly of plant origin, to combat foodborne viruses. Natural plant extracts have several potential uses, not limited to increasing the safety of food products and improving their quality, but also as natural antiviral agents.<\/jats:p>","DOI":"10.3390\/pathogens10091095","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T04:07:28Z","timestamp":1630382848000},"page":"1095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Natural Products and Their Potential Anti-HAV Activity"],"prefix":"10.3390","volume":"10","author":[{"given":"Agnieszka","family":"Jama-Kmiecik","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, Chalubinskiego 4, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Sarowska","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, Chalubinskiego 4, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1972-1548","authenticated-orcid":false,"given":"Dorota","family":"Wojnicz","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Parasitology, Faculty of Medicine, Wroclaw Medical University, J. 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Food."},{"key":"ref_2","first-page":"996","article-title":"Key characteristics of foods with an elevated risk for viral enteropathogen contamination","volume":"26","author":"Yeargin","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0168-1605(03)00169-7","article-title":"Foodborne viruses: An emerging problem","volume":"90","author":"Koopmans","year":"2004","journal-title":"Int. J. Food Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.14252\/foodsafetyfscj.2017028","article-title":"Epidemiology of foodborne norovirus outbreaks\u2013United States, 2009\u20132015","volume":"6","author":"Marsh","year":"2018","journal-title":"Food Saf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijfoodmicro.2003.10.015","article-title":"Modelling effect of physical and chemical parameters on heat inactivation kinetics of hepatitis A virus in a fruit model system","volume":"93","author":"Deboosere","year":"2004","journal-title":"Int. J. Food Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1541-4337.2009.00092.x","article-title":"Viral inactivation in foods: A review of traditional and novel food-processing technologies","volume":"9","author":"Hirneisen","year":"2010","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_7","unstructured":"Melton, L., Shahidi, F., and Varelis, P. (2019). Effect of heat on food properties. Encyclopedia of Food Chemistry, Elsevier."},{"key":"ref_8","unstructured":"Stumbo, C.R. (2013). Thermobacteriology in Food Processing, Elsevier."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.foodcont.2018.08.031","article-title":"Predictive models for thermal inactivation of human norovirus and surrogates in strawberry puree","volume":"96","author":"Bartsch","year":"2019","journal-title":"Food Control."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.4315\/0362-028X.JFP-14-487","article-title":"Thermal inactivation of foodborne enteric viruses and their viral surrogates in foods","volume":"78","author":"Bozkurt","year":"2015","journal-title":"J. Food Prot."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106818","DOI":"10.1016\/j.foodcont.2019.106818","article-title":"Viability RT-qPCR to detect potentially infectious enteric viruses on heat-processed berries","volume":"107","author":"Chen","year":"2020","journal-title":"Food Control."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijfoodmicro.2018.05.013","article-title":"Thermal inactivation of human norovirus surrogates in oyster homogenate","volume":"281","author":"Shao","year":"2018","journal-title":"Int. J. Food Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.fm.2010.05.018","article-title":"A predictive microbiology approach for thermal inactivation of Hepatitis A virus in acidified berries","volume":"7","author":"Deboosere","year":"2010","journal-title":"Food Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijfoodmicro.2018.06.001","article-title":"Foodborne viruses: Detection, risk assesment, and control options in food processing","volume":"285","author":"Bosch","year":"2018","journal-title":"Int. J. Food Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.lwt.2013.04.016","article-title":"Quality evaluation of packaged acidified vegetables subjected to continuous microwave pasteurization","volume":"54","author":"Koskiniemi","year":"2013","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tifs.2013.01.008","article-title":"Mechanism of discoloration in processed garlic and onion","volume":"30","author":"Zang","year":"2013","journal-title":"Trends Food Sci. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/VAAT.S50108","article-title":"Viruses of foodborne origin: A review","volume":"7","author":"Todd","year":"2015","journal-title":"Virus Adapt. Treat."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1365-2672.2005.02635.x","article-title":"Enterically infecting viruses: Pathogenicity, transmission and significance for food and waterborne infection","volume":"98","author":"Carter","year":"2005","journal-title":"J. Appl. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12560-016-9264-2","article-title":"Virological quality of irrigation water in leafy green vegetables and berry fruits production chains food","volume":"9","author":"Kokkinos","year":"2017","journal-title":"Environ. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2212\/spr.2013.1.2","article-title":"Sources of enteric pathogen contamination of fruits and vegetables: Future directions of research","volume":"9","author":"Matthews","year":"2013","journal-title":"Stewart. Postharvest. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijfoodmicro.2011.02.037","article-title":"Opportunities for mitigating pathogen contamination during on-farm food production","volume":"152","author":"Doyle","year":"2012","journal-title":"Int. J. Food Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1108\/00070700610637625","article-title":"Vectors and conditions for preharvest contamination of fruits and vegetables with pathogens capable of causing enteric diseases","volume":"108","author":"Beuchat","year":"2006","journal-title":"Br. Food J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Matthews, K.R., Sapers, G.M., and Gerba, C.P. (2014). Leafy vegetables. The Produce Contamination Problem. Causes and Solutions, Elsevier.","DOI":"10.1016\/B978-0-12-404611-5.00009-9"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.4315\/0362-028X.JFP-12-160","article-title":"Risk factors for microbial contamination in fruits and vegetables at the preharvest level: A systematic review","volume":"75","author":"Park","year":"2012","journal-title":"J. Food Prot."},{"key":"ref_25","unstructured":"World Health Organization (2017). Global Hepatitis Report 2017, World Health Organization."},{"key":"ref_26","unstructured":"European Centre for Disease Prevention and Control (2018). Multi-Country Outbreak of Hepatitis A Virus Genotype IA Infections Affecting EU Countries in 2018\u201421 May 2018, European Centre for Disease Prevention and Control."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/med.21292","article-title":"Molecular biology and inhibitors of hepatitis A virus","volume":"34","author":"Debing","year":"2014","journal-title":"Med. Res. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Vaughan, G., Xia, G., Forbi, J.C., Purdy, M.A., Rossi, L.M., Spradling, P.R., and Khudyakov, Y.E. (2013). Genetic relatedness among hepatitis A virus strains associated with food-borne outbreaks. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074546"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"a033480","DOI":"10.1101\/cshperspect.a033480","article-title":"Hepatitis A Virus Genome Organization and Replication Strategy","volume":"8","author":"McKnight","year":"2018","journal-title":"Cold Spring Harb. Perspect Med."},{"key":"ref_30","first-page":"159","article-title":"Foodborne spread of hepatitis A: Recent studies on virus survival, transfer and inactivation","volume":"11","author":"Sattar","year":"2000","journal-title":"Can. J. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/10408398.2020.1719383","article-title":"Outbreaks, occurrence, and control of norovirus and hepatitis a virus contamination in berries: A review","volume":"61","author":"Bozkurt","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1017\/S0950268819001791","article-title":"Foodborne viral outbreaks associated with frozen produce","volume":"18","author":"Nasheri","year":"2019","journal-title":"Epidemiol. Infect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"618352","DOI":"10.3389\/fmicb.2021.618352","article-title":"Persistence of Hepatitis A Virus RNA in water, on non-porous surfaces, and on blueberries","volume":"12","author":"Jubinville","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12560-019-09375-3","article-title":"Hepatitis A outbreak in the general population due to a MSM-associated HAV genotype linked to a food handler, November 2017\u2013February 2018, Germany","volume":"11","author":"Marosevic","year":"2019","journal-title":"Food Environ. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.meegid.2013.10.023","article-title":"Hepatitis A virus: Host interactions, molecular epidemiology and evolution","volume":"21","author":"Vaughan","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"ref_36","unstructured":"Department of Epidemiology and Surveillance of Infectious Diseases (2021, May 06). Laboratory of Monitoring and Epidemiological Analysis. NIZP-PZH-GIS. Warszawa, Poland, Available online: http:\/\/wwwold.pzh.gov.pl\/oldpage\/epimeld\/2019\/index_mp.html."},{"key":"ref_37","first-page":"433","article-title":"Hepatitis A in Poland in 2016","volume":"72","year":"2018","journal-title":"Epidemiol. Rev."},{"key":"ref_38","first-page":"451","article-title":"Foodborne infections and intoxications in Poland in 2017","volume":"7","author":"Radziszewski","year":"2019","journal-title":"Przegl. Epidemiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"413","DOI":"10.15585\/mmwr.mm6818a2","article-title":"Increase in Hepatitis A Virus Infections\u2014United States, 2013\u20132018","volume":"68","author":"Foster","year":"2019","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_40","unstructured":"(2021, May 06). Essoil Database. Available online: http:\/\/www.nipgr.ac.in\/Essoildb\/."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Leyva-L\u00f3pez, N., Guti\u00e9rrez-Grijalva, E.P., Vazquez-Olivo, G., and Heredia, J.B. (2017). Essential oils of oregano: Biological activity beyond their antimicrobial properties. Molecules., 22.","DOI":"10.3390\/molecules22060989"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3012462","DOI":"10.1155\/2016\/3012462","article-title":"Antimicrobial properties of plant essential oils against human pathogens and their mode of action: An updated review","volume":"2016","author":"Swamy","year":"2016","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jf9708296","article-title":"Antifungal activities of Origanum vulgare subsp. hirtum, Mentha spicata, Lavandula angustifolia, and Salvia fruticosa essential oils against human pathogenic fungi","volume":"46","author":"Adam","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.5897\/AJMR12.1149","article-title":"Essential oils against Candida spp.: In vitro antifungal activity of Origanum vulgare","volume":"7","author":"Cleff","year":"2013","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5219\/554","article-title":"Antifungal activity of lemon, eucalyptus, thyme, oregano, sage and lavender essential oils against Aspergillus niger and Aspergillus tubingensis isolated from grapes","volume":"10","author":"Medo","year":"2016","journal-title":"Potravinarstvo"},{"key":"ref_46","first-page":"14","article-title":"Antifungal activity of essential oil of oregano (Origanum vulgare), marjoram (Origanum majorana) and synergy of two essential oils against Candida albicans","volume":"3","author":"Lakhrissi","year":"2016","journal-title":"Int. J. Res. Stud. Sci. Eng."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/cbdv.201200219","article-title":"Biomolecular characterization of wild sicilian oregano: Phytochemical screening of essential oils and extracts, and evaluation of their antioxidant activities","volume":"10","author":"Tuttolomondo","year":"2013","journal-title":"Chem. Biodivers."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.indcrop.2015.03.079","article-title":"Oregano and lavender essential oils as antioxidant and antimicrobial additives of biogenic gelatin films","volume":"71","author":"Martucci","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"ref_49","first-page":"56","article-title":"Thymus vulgaris essential oil: Chemical composition and antimicrobial activity","volume":"7","author":"Jianu","year":"2014","journal-title":"J. Med. Life"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"270","DOI":"10.15421\/011936","article-title":"Antimicrobial, antibiofilm and biochemichal properties of Thymus vulgaris essential oil against clinical isolates of opportunistic infections","volume":"27","author":"Kryvtsova","year":"2019","journal-title":"Biosyst. Divers."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.foodchem.2013.07.058","article-title":"Fabrication, characterization, and antimicrobial activity of thymol-loaded zein nanoparticles stabilized by sodium caseinate\u2013chitosan hydrochloride double layers","volume":"142","author":"Zhang","year":"2014","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1515\/hepo-2017-0015","article-title":"Antibacterial activity of Zataria multiflora essential oil and its main components against Pseudomonas aeruginosa","volume":"63","author":"Mahboubi","year":"2017","journal-title":"Herba Pol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.phymed.2009.11.004","article-title":"Antistaphylococcal activity of Zataria multiflora essential oil and its synergy with vancomycin","volume":"17","author":"Mahboubi","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.fct.2010.03.025","article-title":"Chemical composition of essential oils in Zataria multiflora Boiss. from different parts of Iran and their radical scavenging and antimicrobial activity","volume":"48","author":"Tajik","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_55","first-page":"S43","article-title":"Antibacterial activity of Zataria multiflora Boiss essential oil against extended spectrum \u03b2 lactamase produced by urinary isolates of Klebsiella pneumoniae","volume":"4","author":"Eftekhar","year":"2011","journal-title":"Jundishapur J. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/14786419.2010.543422","article-title":"Biopreservation of hamburgers by essential oil of Zataria multiflora","volume":"26","author":"Samadi","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"ref_57","first-page":"238","article-title":"Application of Zataria multiflora Boiss. and Cinnamon zeylanicum essential oils as two natural preservatives in cake","volume":"3","author":"Kordsardouei","year":"2013","journal-title":"Avicenna J. Phytomed."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12944-017-0487-5","article-title":"Citrus lemon essential oil: Chemical composition, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in minced beef meat","volume":"16","author":"Hsouna","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12560-019-09367-3","article-title":"Antiviral activity of essential oils against hepatitis A virus in soft fruits","volume":"11","author":"Battistini","year":"2019","journal-title":"Food Environ. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e37103","DOI":"10.15171\/ijep.2016.13","article-title":"Evaluation of antibacterial activities of Citrus limon, Citrus reticulata, and Citrus grandis against pathogenic bacteria","volume":"4","author":"Saeb","year":"2016","journal-title":"Int. J. Enteric Pathog."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Man, A., Santacroce, L., Jacob, R., Mare, A., and Man, L. (2019). Antimicrobial activity of six essential oils against a group of human pathogens: A comparative study. Pathogens, 8.","DOI":"10.3390\/pathogens8010015"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1021\/jf5006148","article-title":"Antifungal activity of citrus essential oils: A review","volume":"62","author":"Jing","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40538-019-0160-5","article-title":"Bioactivity of Citrus essential oils (CEOs) against microorganisms associated with spoilage of some fruits","volume":"6","author":"Ogidi","year":"2019","journal-title":"Chem. Biol. Technol. Agric."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Dosoky, N.S., and Setzer, W.N. (2018). Biological activities and safety of Citrus spp. essential oils. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071966"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.foodcont.2010.06.008","article-title":"Determination of bactericidal efficacy of essential oil extracted from orange peel on the food contact surfaces","volume":"21","author":"Lin","year":"2010","journal-title":"Food Control"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Bourgou, S., Zohra, F., Ourghemmi, I., and Saidani, M. (2012). Changes of peel essential oil composition of four Tunisian citrus during fruit maturation. Sci. World J., 528593.","DOI":"10.1100\/2012\/528593"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.foodcont.2012.01.050","article-title":"Inhibition of foodborne pathogen bacteria by essential oils extracted from citrus fruits cultivated in Sicily","volume":"26","author":"Settani","year":"2012","journal-title":"Food Control"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.micres.2006.06.009","article-title":"Effects of Citrus sinensis (L.) Osbeck epicarp essential oil on growth and morphogenesis of Aspergillus niger (L.) Van Tieghem","volume":"163","author":"Sharma","year":"2008","journal-title":"Microbiol. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.foodcont.2007.12.003","article-title":"Antifungal activity of lemon (Citrus limon L.), mandarin (Citrus reticulata L.), grapefruit (Citrus paradisi L.) and orange (Citrus sinensis L.) essential oils","volume":"19","year":"2008","journal-title":"Food Control"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.fct.2010.04.001","article-title":"Chemical profile, antifungal, antiaflatoxigenic and antioxidant activity of Citrus maxima Burm. and Citrus sinensis (L.) Osbeck essential oils and their cyclic monoterpene, dl-limonene","volume":"48","author":"Singh","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.2174\/13852728113179990122","article-title":"Current and potential use of citrus essential oils","volume":"17","author":"Palazzolo","year":"2013","journal-title":"Curr. Org. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ptr.5964","article-title":"Citrus essential oils inhalation by mice: Behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation","volume":"32","author":"Zamboni","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_73","first-page":"16","article-title":"Antibacterial activity of Citrus paradisi essential oil","volume":"8","author":"Vasek","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1111\/j.1365-2621.2011.02640.x","article-title":"Essential oil composition and antibacterial activity of the grapefruit (Citrus paradisi L.) peel essential oils obtained by solvent-free microwave extraction: Comparison with hydrodistillation","volume":"46","author":"Uysal","year":"2011","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Deng, W., Liu, K., Cao, S., Sun, J., Zhong, B., and Chun, J. (2020). Chemical composition, antimicrobial, antioxidant, and antiproliferative properties of grapefruit essential oil prepared by molecular distillation. Molecules, 25.","DOI":"10.3390\/molecules25010217"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1515\/znc-2020-0126","article-title":"Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume)","volume":"76","author":"Teneva","year":"2021","journal-title":"Z. Naturforsch."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/1082013219883465","article-title":"Grapefruit essential oils inhibit quorum sensing of Pseudomonas aeruginosa","volume":"26","author":"Luciardi","year":"2019","journal-title":"Food Sci. Technol. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9334","DOI":"10.3390\/molecules18089334","article-title":"The potential of use Basil and Rosemary essential oils as effective antibacterial agents","volume":"18","author":"Sienkiewicz","year":"2013","journal-title":"Molecules"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijfoodmicro.2004.03.022","article-title":"Essential oils: Their antibacterial properties and potential applications in foods\u2014A review","volume":"94","author":"Burt","year":"2004","journal-title":"Int. J. Food Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1590\/S1517-83822010000400027","article-title":"Rosmarinus officinalis essential oil: Antiproliferative, antioxidant and antibacterial activities","volume":"41","author":"Hussain","year":"2010","journal-title":"Braz. J. Microbiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5455\/njppp.2017.7.7021513102016","article-title":"In vitro antifungal effect of Rosmarinus officinalis essential oil on Aspergillus niger","volume":"7","author":"Baghloul","year":"2017","journal-title":"Natl. J. Physiol. Pharm. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/19440049.2019.1678771","article-title":"Antifungal and antiaflatoxigenic activity of rosemary essential oil (Rosmarinus officinalis L.) against Aspergillus flavus","volume":"37","author":"Kohiyama","year":"2020","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1515\/biol-2020-0045","article-title":"Antifungal activity of selected volatile essential oils against Penicillium sp","volume":"15","author":"Vukovic","year":"2020","journal-title":"Open Life Sci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Nieto, G., Ros, G., and Castillo, J. (2018). Antioxidant and antimicrobial properties of rosemary (Rosmarinus officinalis L.): A review. Medicines, 5.","DOI":"10.3390\/medicines5030098"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4167\/jbv.2009.39.2.61","article-title":"Chemical composition and antimicrobial activity of the essential oil of Chrysanthemum indicum against oral bacteria","volume":"39","author":"Jung","year":"2009","journal-title":"J. Bacteriol. Virol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jep.2004.08.031","article-title":"Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum","volume":"96","author":"Shunying","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.15666\/aeer\/1706_1335513369","article-title":"A review of chrysanthemum, the eastern queen in traditional chinese medicine with healing power in modern pharmaceutical sciences","volume":"17","author":"Shahrajabian","year":"2019","journal-title":"Appl. Ecol. Environ. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bse.2017.07.001","article-title":"Variation in morphological characters, chemical composition, and anthocyanin content of different Chrysanthemum morifolium cultivars from Iran","volume":"74","author":"Hodaei","year":"2017","journal-title":"Biochem. System. Ecol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7","DOI":"10.22270\/jddt.v10i2-s.4015","article-title":"Chemical composition, antibacterial activity of essential oil and anatomical study of Chrysanthemum morifolium","volume":"10","author":"Boukhebti","year":"2020","journal-title":"J. Drug Deliv. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Zhang, K., Jiang, Y., Zhao, H., K\u00f6llner, T.G., Chen, S., Chen, F., and Chen, F. (2020). Diverse terpenoids and their associated antifungal properties from roots of different cultivars of Chrysanthemum morifolium Ramat. Molecules, 25.","DOI":"10.3390\/molecules25092083"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/2225-4110.124335","article-title":"Antiviral natural products and herbal medicines","volume":"4","author":"Lin","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Youssef, F.S., Eid, S.Y., Alshammari, E., Ashour, M.L., Wink, M., and El-Readi, M.Z. (2020). Chrysanthemum indicum and Chrysanthemum morifolium: Chemical composition of their essential oils and their potential use as natural preservatives with antimicrobial and antioxidant activities. Foods, 9.","DOI":"10.3390\/foods9101460"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12560-015-9181-9","article-title":"Evaluation of natural compounds of plant origin for inactivation of enteric viruses","volume":"7","author":"Sanchez","year":"2015","journal-title":"Food Environ. Virol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.indcrop.2014.05.055","article-title":"A Status Review on the Medicinal Properties of Essential Oils","volume":"62","author":"Raut","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Behl, T., Rocchetti, G., Chadha, S., Zengin, G., Bungau, S., Kumar, A., Mehta, V., Uddin, M.S., Khullar, G., and Setia, D. (2021). Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview. Pharmaceuticals, 14.","DOI":"10.3390\/ph14040381"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.fm.2017.04.018","article-title":"Effect of green tea extract on enteric viruses and its application as natural sanitizer","volume":"66","author":"Randazzo","year":"2017","journal-title":"Food Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.foodchem.2004.01.070","article-title":"Biological and anti-microbial activity of irradiated green tea polyphenols","volume":"88","author":"An","year":"2004","journal-title":"Food Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1750-3841.2008.00899.x","article-title":"Evaluation of antibacterial activity of whey protein isolate coating incorporated with nisin, grape seed extract, malic acid, and EDTA on a turkey frankfurter system","volume":"73","author":"Gadang","year":"2008","journal-title":"J. Food Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tifs.2005.10.005","article-title":"Novel uses of catechins in foods","volume":"17","author":"Yilmaz","year":"2006","journal-title":"Trends Food Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"108809","DOI":"10.1016\/j.ijfoodmicro.2020.108809","article-title":"Green tea extract assisted low-temperature pasteurization to inactivate enteric viruses in juices","volume":"334","author":"Randazzo","year":"2020","journal-title":"Int. J. Food Microbiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0963-9969(01)00129-6","article-title":"Anthocyanin and antioxidant capacity in Roselle (Hibiscus sabdariffa L.) extract","volume":"35","author":"Tsai","year":"2002","journal-title":"Food Res. Int."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1021\/jf4020735","article-title":"Polyphenols of Hibiscus sabdariffa improved diabetic nephropathy via attenuating renal epithelial mesenchymal transition","volume":"61","author":"Yang","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3945\/jn.109.115097","article-title":"Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults","volume":"140","author":"McKay","year":"2010","journal-title":"J. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/ptr.1760","article-title":"In vitro antibacterial activity of roselle calyx and protocatechuic acid","volume":"19","author":"Liu","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12560-015-9209-1","article-title":"Aqueous Extracts of Hibiscus sabdariffa Calyces Decrease Hepatitis A Virus and Human Norovirus Surrogate Titers","volume":"7","author":"Joshi","year":"2015","journal-title":"Food Environ. Virol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"El-Shiekh, R.A., Abdelmohsen, U.R., Ashour, H.M., and Ashour, R.M. (2020). Novel Antiviral and Antibacterial Activities of Hibiscus schizopetalus. Antibiotics, 9.","DOI":"10.3390\/antibiotics9110756"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12560-016-9247-3","article-title":"Reduction of Enteric Viruses by Blueberry Juice and Blueberry Proanthocyanidins","volume":"8","author":"Joshi","year":"2016","journal-title":"Food Environ. Virol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coviro.2013.12.006","article-title":"Phytocompounds for the control of human enteric viruses","volume":"4","year":"2014","journal-title":"Curr. Opin. Virol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0963-9969(02)00116-3","article-title":"Antibacterial and antioxidant activities of grape (Vitis vinifera) seed extracts","volume":"36","author":"Jayaprakasha","year":"2003","journal-title":"Food Res. Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fm.2015.05.011","article-title":"Antiviral effects of grape seed extract against feline calicivirus, murine norovirus, and hepatitis A virus in model food systems and under gastric conditions","volume":"52","author":"Joshi","year":"2015","journal-title":"Food Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1128\/AEM.00193-11","article-title":"Grape seed extract for control of human enteric viruses","volume":"77","author":"Su","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12560-016-9235-7","article-title":"Efficacy of cinnamaldehyde against enteric viruses and its activity after incorporation into biodegradable multilayer systems of interest in food packaging","volume":"8","author":"Fabra","year":"2016","journal-title":"Food Environ. Virol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5142\/jgr.2011.35.4.429","article-title":"Antiviral effect of korean red ginseng extract and ginsenosides on murine norovirus and feline calicivirus as surrogates for human norovirus","volume":"35","author":"Lee","year":"2011","journal-title":"J. Ginseng Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/1750-3841.12205","article-title":"Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides","volume":"78","author":"Lee","year":"2013","journal-title":"J. Food Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fm.2013.02.009","article-title":"Inactivation of food-borne viruses using natural biochemical substances","volume":"35","author":"Li","year":"2013","journal-title":"Food Microbiol."},{"key":"ref_116","first-page":"291","article-title":"Bioactive phenolic compounds from the Egyptian Red Sea seagrass Thalassodendron ciliatum","volume":"67","author":"Hamdy","year":"2012","journal-title":"Z. Nat. C"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ptr.2295","article-title":"Antiviral effects of Glycyrrhiza species","volume":"22","author":"Fiore","year":"2008","journal-title":"Phytother. 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