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Moreover, the absence of a vaccine against these diseases and drug resistance in mosquitoes necessitates the development of new control strategies for vector-borne diseases. ABC transporters that play a vital role in immunity and other cellular processes in different organisms may act as non-canonical immune molecules against arboviruses, however, their role in mosquito immunity remains unexplored. This study comprehensively analyzed various genetic features of putative ABC transporters and classified them into A-H subfamilies based on their evolutionary relationships. Existing RNA-sequencing data analysis indicated higher expression of cytosolic ABC transporter genes (E &amp; F Subfamily) throughout the mosquito development, while members of other subfamilies exhibited tissue and time-specific expression. Furthermore, comparative gene expression analysis from the microarray dataset of mosquito infected with dengue, yellow fever and West Nile viruses revealed 31 commonly expressed ABC transporters suggesting a potentially conserved transcriptomic signature of arboviral infection. Among these, only a few transporters of ABCA, ABCC and ABCF subfamily were upregulated, while most were downregulated. This indicates the possible involvement of ABC transporters in mosquito immunity.<\/jats:p>","DOI":"10.3390\/pathogens10091127","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T23:05:12Z","timestamp":1630623912000},"page":"1127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Delineating the Role of Aedes aegypti ABC Transporter Gene Family during Mosquito Development and Arboviral Infection via Transcriptome Analyses"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-6808","authenticated-orcid":false,"given":"Vikas","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani Campus, Pilani 333031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology and Science (BITS), Pilani Campus, Pilani 333031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Zoology, Chaudhary Bansi Lal University, Bhiwani 127021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-0495","authenticated-orcid":false,"given":"Kuldeep","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, School of Medicine, 470 Cancer Research Building-II, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-4934","authenticated-orcid":false,"given":"Cheikh Tidiane","family":"Diagne","sequence":"additional","affiliation":[{"name":"MIVEGEC, Univ. 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