{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:04:02Z","timestamp":1774526642601,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Background: There is no consensus for the best treatment of complex cutaneous leishmaniasis (CL). We aimed to describe a cohort of CL, focusing on liposomal amphotericin B (L-AmB) treatment outcome. Methods: We performed a retrospective study in Vall d\u2019Hebron University Hospital (Barcelona, Spain). All patients with parasitologically proven CL diagnosed from 2012 to 2018 were included. Results: The analysis included 41 patients with CL. The median age was 39 years (IQR 12- 66); 12 (29%) were children, and 29 (71%) were men. Regarding treatment, 24 (59%) received local treatment, whereas 17 (41%) had complex CL and were offered intravenous systemic treatment. Sixteen patients received L-AmB; eight (50%) had adverse events, and three (19%) discontinued treatment for safety reasons. All cases were considered cured within the first year post-treatment. Conclusions: L-AmB for complex CL showed no treatment failures, offering an alternative treatment option for patients with complex CL. Clinicians should pay close attention to the potential adverse events of L-AmB and adopt an active drug safety surveillance scheme to rapidly detect reversible side effects.<\/jats:p>","DOI":"10.3390\/pathogens10101253","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:38:09Z","timestamp":1632865089000},"page":"1253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of Complex Cutaneous Leishmaniasis with Liposomal Amphotericin B"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-197X","authenticated-orcid":false,"given":"Maria","family":"Ubals","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"},{"name":"Doctoral Programme in Medicine and Translational Research: International Health Track, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7435-1829","authenticated-orcid":false,"given":"Pau","family":"Bosch-Nicolau","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitari Vall d\u2019Hebron, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-5447","authenticated-orcid":false,"given":"Adri\u00e1n","family":"S\u00e1nchez-Montalv\u00e1","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitari Vall d\u2019Hebron, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Universitari Vall d\u2019Hebron, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Aparicio-Espa\u00f1ol","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"},{"name":"Facultat de Medicina, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-6060","authenticated-orcid":false,"given":"Elena","family":"Sulleiro","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Universitari Vall d\u2019Hebron, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aroa","family":"Silgado","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Universitari Vall d\u2019Hebron, PROSICS Barcelona, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9613-7228","authenticated-orcid":false,"given":"Antoni","family":"Soriano-Arandes","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-7649","authenticated-orcid":false,"given":"Maria","family":"Espiau","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berta","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-6241","authenticated-orcid":false,"given":"Diana","family":"Pou","sequence":"additional","affiliation":[{"name":"Tropical Medicine and International Health Unit, Drassanes-Vall d\u2019Hebron, PROSICS Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-8288","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Trevi\u00f1o","sequence":"additional","affiliation":[{"name":"Tropical Medicine and International Health Unit, Drassanes-Vall d\u2019Hebron, PROSICS Barcelona, 08035 Barcelona, 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