{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:13:10Z","timestamp":1791951190846,"version":"4.3.4"},"reference-count":125,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Vancomycin is frequently prescribed in pediatrics, especially in intensive care unit settings, to treat Gram-positive bacterial infections. This work aims to collect the top-cited articles of pediatric and infectious diseases areas to gather the current evidence and gaps of knowledge on the use of vancomycin in these populations. The most relevant journals reported in the \u201cpediatrics\u201d and \u201cinfectious diseases\u201d categories of the 2019 edition of Journal Citation Reports were browsed. Articles with more than 30 citations and published over the last three decades were collected. A bibliometric analysis was performed and 115 articles were retrieved. They were published in 21 journals, with a median impact factor of 4.6 (IQR 2.9\u20135.4). Sixty-eight of them (59.1%) belonged to \u201cinfectious diseases\u201d journals. The most relevant topic was \u201cbloodstream\/complicated\/invasive infections\u201d, followed by \u201cantibiotic resistance\/MRSA treatment\u201d. As for population distribution, 27 articles were on children only and 27 on neonates, most of which were from intensive care unit (ICU) settings. The current literature mainly deals with vancomycin as a treatment for severe infections and antibiotic resistance, especially in neonatal ICU settings. Lately, attention to new dosing strategies in the neonatal and pediatric population has become a sensible topic.<\/jats:p>","DOI":"10.3390\/pathogens10101343","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T03:01:13Z","timestamp":1634698873000},"page":"1343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vancomycin Use in Children and Neonates across Three Decades: A Bibliometric Analysis of the Top-Cited Articles"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-9952","authenticated-orcid":false,"given":"Chiara","family":"Minotti","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Women\u2019s and Children\u2019s Health, University of Padova, 35100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-8784","authenticated-orcid":false,"given":"Elisa","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Women\u2019s and Children\u2019s Health, University of Padova, 35100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Giaquinto","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Women\u2019s and Children\u2019s Health, University of Padova, 35100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Don\u00e0","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Women\u2019s and Children\u2019s Health, University of Padova, 35100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1086\/491712","article-title":"The pharmacokinetic and pharmacodynamic properties of vancomycin","volume":"42","author":"Rybak","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1128\/AAC.01674-10","article-title":"Refining vancomycin protein binding estimates: Identification of clinical factors that influence protein binding","volume":"55","author":"Butterfield","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1172\/JCI68834","article-title":"Mechanisms of vancomycin resistance in Staphylococcus aureus","volume":"124","author":"Gardete","year":"2014","journal-title":"J. Clin. Invest."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1128\/JCM.41.10.4660-4665.2003","article-title":"Decreased Vancomycin Susceptibility of Coagulase-Negative Staphylococci in a Neonatal Intensive Care Unit: Evidence of Spread of Staphylococcus warneri","volume":"41","author":"Center","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"ref_5","first-page":"269","article-title":"Vancomycin Resistance in Staphylococcus Aureus","volume":"90","author":"McGuinness","year":"2017","journal-title":"Yale J. Biol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1542\/peds.2005-2429","article-title":"Adverse Drug Reactions among Children over a 10-Year Period","volume":"118","author":"Le","year":"2006","journal-title":"Pediatrics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jac\/27.suppl_B.17","article-title":"Anaphylactoid reactions to glycopeptide antibiotics","volume":"27","author":"Polk","year":"1991","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0924-8579(98)00025-9","article-title":"Comparative safety of teicoplanin and vancomycin","volume":"10","author":"Wilson","year":"1998","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1001\/jamapediatrics.2016.1477","article-title":"Epidemiology and Mortality of Staphylococcus aureus Bacteremia in Australian and New Zealand Children","volume":"170","author":"McMullan","year":"2016","journal-title":"JAMA Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.clp.2007.11.014","article-title":"Hospital-Acquired Infections in the NICU: Epidemiology for the New Millennium","volume":"35","author":"Carey","year":"2008","journal-title":"Clin. Perinatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1053\/j.semperi.2012.06.004","article-title":"Methicillin-Resistant Staphylococcus aureus in the Neonatal Intensive Care Unit","volume":"36","author":"Nelson","year":"2012","journal-title":"Semin. Perinatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e794","DOI":"10.1542\/peds.2011-3886","article-title":"Antibiotic Exposure and IBD Development among Children: A Population-Based Cohort Study","volume":"130","author":"Kronman","year":"2012","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"F221","DOI":"10.1136\/fn.81.3.F221","article-title":"Pharmacokinetics and dose requirements of vancomycin in neonates","volume":"81","author":"Grimsley","year":"1999","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1093\/jac\/dkq257","article-title":"Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms","volume":"65","author":"Singh","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/acsinfecdis.7b00258","article-title":"Developments in Glycopeptide Antibiotics","volume":"4","author":"Blaskovich","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(05)70243-7","article-title":"Meticillin-resistant Staphylococcus aureus","volume":"5","author":"Boyce","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1086\/518452","article-title":"Counterpoint: Vancomycin and Staphylococcus aureus--An Antibiotic Enters Obsolescence","volume":"44","author":"Deresinski","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1294","DOI":"10.1542\/peds.2009-2867","article-title":"Antibiotic Management of Staphylococcus aureus Infections in US Children\u2019s Hospitals, 1999\u20132008","volume":"125","author":"Herigon","year":"2010","journal-title":"Pediatrics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1086\/520284","article-title":"Epidemiology, Appropriateness, and Cost of Vancomycin Use","volume":"26","author":"Jarvis","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1086\/491710","article-title":"Microbiological Features of Vancomycin in the 21st Century: Minimum Inhibitory Concentration Creep, Bactericidal\/Static Activity, and Applied Breakpoints to Predict Clinical Outcomes or Detect Resistant Strains","volume":"42","author":"Jones","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1086\/491714","article-title":"The Role of Vancomycin in the Treatment Paradigm","volume":"42","author":"Stevens","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1086\/491708","article-title":"Vancomycin: A 50-Year Reassessment","volume":"42","author":"Moellering","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1086\/518451","article-title":"Point: Vancomycin is not obsolete for the treatment of infection caused by methicillin-resistant Staphylococcus aureus","volume":"44","author":"Mohr","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/cid\/cir078","article-title":"Vancomycin: We Can\u2019t Get There From Here","volume":"52","author":"Patel","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1542\/peds.110.4.e42","article-title":"Evaluation and treatment of neonates with suspected late-onset sepsis: A survey of neonatologists\u2019 practices","volume":"110","author":"Rubin","year":"2002","journal-title":"Pediatrics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1086\/491709","article-title":"Vancomycin: A History","volume":"42","author":"Levine","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1086\/420939","article-title":"Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy","volume":"38","author":"Tice","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1086\/491711","article-title":"Vancomycin Resistance in Gram-Positive Cocci","volume":"42","author":"Courvalin","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1469-0691.2007.01912.x","article-title":"Heteroresistance: A concern of increasing clinical significance?","volume":"14","author":"Falagas","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1093\/cid\/cit613","article-title":"Methicillin-Resistant Staphylococcus aureus: An Evolving Pathogen","volume":"58","author":"Stryjewski","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1086\/425321","article-title":"Emergence of New Strains of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit","volume":"39","author":"Healy","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1086\/499406","article-title":"The Relationship between Antimicrobial Resistance and Patient Outcomes: Mortality, Length of Hospital Stay, and Health Care Costs","volume":"42","author":"Cosgrove","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1086\/321815","article-title":"Vancomycin-Resistant Enterococci: Mechanisms and Clinical Observations","volume":"33","author":"Gold","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1086\/317542","article-title":"Vancomycin-Intermediate and -Resistant Staphylococcus aureus: What the Infectious Disease Specialist Needs to Know","volume":"32","author":"Weinstein","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0163-4453(96)80003-X","article-title":"Mechanisms of glycopeptide resistance in enterococci","volume":"32","author":"Arthur","year":"1996","journal-title":"J. Infect."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.semperi.2007.01.004","article-title":"Antibiotic-Resistant Organisms in the Neonatal Intensive Care Unit","volume":"31","author":"Bizzarro","year":"2007","journal-title":"Semin. Perinatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1542\/peds.113.4.e347","article-title":"Community-Acquired Methicillin-Resistant Staphylococcus aureus in Southern New England Children","volume":"113","author":"Dietrich","year":"2004","journal-title":"Pediatrics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1086\/422002","article-title":"The Role of the Intestinal Tract as a Reservoir and Source for Transmission of Nosocomial Pathogens","volume":"39","author":"Donskey","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1086\/514910","article-title":"Enterococci and Vancomycin Resistance","volume":"27","author":"French","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0163-4453(96)91622-9","article-title":"Lactobacillus rhamnosus infection in a child following bone marrow transplant","volume":"32","author":"Kalima","year":"1996","journal-title":"J. Infect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1086\/519470","article-title":"Limitations of Vancomycin in the Management of Resistant Staphylococcal Infections","volume":"45","author":"Kollef","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/clind\/15.3.495","article-title":"Resistance of Enterococci to Aminoglycosides and Glycopeptides","volume":"15","author":"Leclercq","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/clind\/24.4.545","article-title":"Resistance to Glycopeptides in Enterococci","volume":"24","author":"Leclercq","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1093\/cid\/ciq146","article-title":"Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children","volume":"52","author":"Liu","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1086\/520283","article-title":"Vancomycin-Resistant Enterococci","volume":"26","author":"Moellering","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/cid\/cit020","article-title":"The Global Spread of Healthcare-Associated Multidrug-Resistant Bacteria: A Perspective From Asia","volume":"56","author":"Molton","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1086\/653518","article-title":"Staphylococcus aureus: Methicillin-SusceptibleS. aureusto Methicillin-ResistantS. aureusand Vancomycin-Resistant S. aureus","volume":"51","author":"Rehm","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1093\/cid\/cit614","article-title":"Methicillin-Resistant Staphylococcus aureus Therapy: Past, Present, and Future","volume":"58","author":"Rodvold","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S378","DOI":"10.1086\/533594","article-title":"Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus","volume":"46","author":"Rubinstein","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S368","DOI":"10.1086\/533593","article-title":"Skin and Soft-Tissue Infections Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus","volume":"46","author":"Stryjewski","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1086\/499819","article-title":"Bad Bugs Need Drugs: An Update on the Development Pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America","volume":"42","author":"Talbot","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1086\/655698","article-title":"Risk Factors and Predictors for Candidemia in Pediatric Intensive Care Unit Patients: Implications for Prevention","volume":"51","author":"Zaoutis","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0924-8579(98)00033-8","article-title":"The utility of aminoglycosides in an era of emerging drug resistance","volume":"10","author":"Zembower","year":"1998","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.siny.2004.10.004","article-title":"New dosing strategies for antibacterial agents in the neonate","volume":"10","author":"Mouton","year":"2005","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijantimicag.2013.11.006","article-title":"Dose optimisation of antibiotics in children: Application of pharmacokinetics\/pharmacodynamics in paediatrics","volume":"43","author":"Downes","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1001\/jamapediatrics.2015.132","article-title":"Drug Dosing and Pharmacokinetics in Children With Obesity A Systematic Review","volume":"169","author":"Hill","year":"2015","journal-title":"JAMA Pediatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.siny.2012.10.003","article-title":"Use of antibacterial agents in the neonate: 50 years of experience with vancomycin administration","volume":"18","author":"Zhao","year":"2013","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/archdischild-2014-306873","article-title":"Therapeutic guidelines for prescribing antibiotics in neonates should be evidence-based: A French national survey","volume":"100","author":"Leroux","year":"2015","journal-title":"Arch. Dis. Child."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/clinids\/18.4.544","article-title":"Editorial: Monitoring Serum Vancomycin Levels: Climbing the Mountain Because It Is There?","volume":"18","author":"Moellering","year":"1994","journal-title":"Clin. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"F365","DOI":"10.1136\/adc.2010.196402","article-title":"Vancomycin prescription in neonates and young infants: Toward a simplified dosage","volume":"96","author":"Oudin","year":"2011","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"F418","DOI":"10.1136\/adc.2007.128280","article-title":"Continuous-infusion vancomycin therapy for preterm neonates with suspected or documented Gram-positive infections: A new dosage schedule","volume":"93","author":"Plan","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1542\/peds.2010-1427","article-title":"Committee on Infectious Diseases and Section on Otolaryngology-Head and Neck Surgery Cochlear Implants in Children: Surgical Site Infections and Prevention and Treatment of Acute Otitis Media and Meningitis","volume":"126","author":"Rubin","year":"2010","journal-title":"Pediatrics"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/jac\/dkf212","article-title":"Vancomycin therapeutic drug monitoring: Is there a consensus view? The results of a UK National External Quality Assessment Scheme (UK NEQAS) for Antibiotic Assays questionnaire","volume":"50","author":"Tobin","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/archdischild-2012-302765","article-title":"Vancomycin continuous infusion in neonates: Dosing optimisation and therapeutic drug monitoring","volume":"98","author":"Zhao","year":"2013","journal-title":"Arch. Dis. Child."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1542\/peds.2004-2806","article-title":"Newborn Hearing Screening in the NICU: Profile of Failed Auditory Brainstem Response\/Passed Otoacoustic Emission","volume":"116","author":"Berg","year":"2005","journal-title":"Pediatrics"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1067\/mpd.2003.mpd037","article-title":"Newborn hearing screening: Tobramycin and vancomycin are not risk factors for hearing loss","volume":"142","author":"Hop","year":"2003","journal-title":"J. Pediatr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e173219","DOI":"10.1001\/jamapediatrics.2017.3219","article-title":"Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin\/Tazobactam Treatment Among Hospitalized Children","volume":"171","author":"Downes","year":"2017","journal-title":"JAMA Pediatr."},{"key":"ref_69","first-page":"666","article-title":"Systematic Review and Meta-Analysis of Acute Kidney Injury Associated with Concomitant Vancomycin and Piperacillin\/tazobactam","volume":"64","author":"Hammond","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jpeds.2010.08.019","article-title":"Incidence and risk factors influencing the development of vancomycin nephrotoxicity in children","volume":"158","author":"McKamy","year":"2011","journal-title":"J. Pediatr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"F207","DOI":"10.1136\/fn.85.3.F207","article-title":"Nephrocalcinosis in preterm babies","volume":"85","author":"Narendra","year":"2001","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00467-008-0997-5","article-title":"Human renal function maturation: A quantitative description using weight and postmenstrual age","volume":"24","author":"Rhodin","year":"2009","journal-title":"Pediatr. Nephrol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s00467-014-2837-0","article-title":"Acute kidney injury in preterm infants admitted to a neonatal intensive care unit","volume":"29","author":"Barisic","year":"2014","journal-title":"Pediatr. Nephrol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1086\/653519","article-title":"Serious Infections Caused by Methicillin-Resistant Staphylococcus aureus","volume":"51","author":"Boucher","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1086\/376637","article-title":"Vancomycin versus Placebo for Treating Persistent Fever in Patients with Neutropenic Cancer Receiving Piperacillin-Tazobactam Monotherapy","volume":"37","author":"Cometta","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/PCC.0b013e3181988798","article-title":"Severe invasive community-associated methicillin-resistant Staphylococcus aureus infections in previously healthy children *","volume":"10","author":"Creel","year":"2009","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/infdis\/170.3.720","article-title":"Vancomycin Penetration Into Biofilm Covering Infected Prostheses And Effect On Bacteria","volume":"170","author":"Darouiche","year":"1994","journal-title":"J. Infect. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/MPG.0b013e31816fee95","article-title":"Long-term Treatment of Primary Sclerosing Cholangitis in Children With Oral Vancomycin: An Immunomodulating Antibiotic","volume":"47","author":"Davies","year":"2008","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jinf.2005.11.185","article-title":"Staphylococcus aureus bacteraemia in children and neonates: A 10 year retrospective review","volume":"53","author":"Denniston","year":"2006","journal-title":"J. Infect."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1542\/peds.2007-3070","article-title":"Invasive Kingella kingae Infections in Children: Clinical and Laboratory Characteristics","volume":"122","author":"Scheuerman","year":"2008","journal-title":"Pediatrics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1473-3099(07)70312-2","article-title":"Linezolid versus glycopeptide or \u03b2-lactam for treatment of Gram-positive bacterial infections: Meta-analysis of randomised controlled trials","volume":"8","author":"Falagas","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1542\/peds.2004-2674","article-title":"A Vancomycin-Heparin Lock Solution for Prevention of Nosocomial Bloodstream Infection in Critically Ill Neonates With Peripherally Inserted Central Venous Catheters: A Prospective, Randomized Trial","volume":"116","author":"Garland","year":"2005","journal-title":"Pediatrics"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/jac\/40.1.135","article-title":"Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility","volume":"40","author":"Hiramatsu","year":"1997","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0022-3476(94)70207-1","article-title":"Prevention of gram-positive sepsis in neonates weighing less than 1500 grams","volume":"125","author":"Kacica","year":"1994","journal-title":"J. Pediatr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1542\/peds.106.6.1387","article-title":"Fulminant Late-Onset Sepsis in a Neonatal Intensive Care Unit, 1988-1997, and the Impact of Avoiding Empiric Vancomycin Therapy","volume":"106","author":"Karlowicz","year":"2000","journal-title":"Pediatrics"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1542\/peds.107.1.61","article-title":"Review of 49 neonates with acquired fungal sepsis: Further characterization","volume":"107","author":"Makhoul","year":"2001","journal-title":"Pediatrics"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jac\/44.suppl_1.19","article-title":"Optimal treatment of complicated skin and skin structure infections","volume":"44","author":"Nichols","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1203\/PDR.0b013e318232a984","article-title":"Farnesol Decreases Biofilms of Staphylococcus epidermidis and Exhibits Synergy With Nafcillin and Vancomycin","volume":"70","author":"Pammi","year":"2011","journal-title":"Pediatr. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0022-3476(95)70276-8","article-title":"A randomized, controlled trial of the efficacy ofheparin and vancomycin solution in preventing central venous catheter infections in children","volume":"127","author":"Rackoff","year":"1995","journal-title":"J. Pediatr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1086\/505976","article-title":"Use of Vancomycin-Containing Lock or Flush Solutions for Prevention of Bloodstream Infection Associated with Central Venous Access Devices: A Meta-Analysis of Prospective, Randomized Trials","volume":"43","author":"Safdar","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/infdis\/167.2.487","article-title":"A Prospective Study of the Catheter Hub as the Portal of Entry for Microorganisms Causing Catheter-Related Sepsis in Neonates","volume":"167","author":"Salzman","year":"1993","journal-title":"J. Infect. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1473-3099(05)70113-4","article-title":"Management of anthrax meningitis","volume":"5","author":"Sejvar","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e566","DOI":"10.1542\/peds.2010-2117","article-title":"Microbiology and Antibiotic Management of Orbital Cellulitis","volume":"127","author":"Seltz","year":"2011","journal-title":"Pediatrics"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.jinf.2013.09.011","article-title":"Neonatal sepsis: Progress towards improved outcomes","volume":"68","author":"Shane","year":"2014","journal-title":"J. Infect."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"F105","DOI":"10.1136\/fn.79.2.F105","article-title":"Double blind, randomised, placebo controlled study of oral vancomycin in prevention of necrotising enterocolitis in preterm, very low birthweight infants","volume":"79","author":"Siu","year":"1998","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0022-3476(94)70208-X","article-title":"Prevention of central venous catheter-related coagulase-negative staphylococcal sepsis in neonates","volume":"125","author":"Spafford","year":"1994","journal-title":"J. Pediatr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1093\/cid\/ciw861","article-title":"2017 Infectious Diseases Society of America\u2019s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis *","volume":"64","author":"Tunkel","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000226604","article-title":"Long-Term Trends in the Epidemiology of Neonatal Sepsis and Antibiotic Susceptibility of Causative Agents","volume":"97","author":"Gerards","year":"2010","journal-title":"Neonatology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1093\/cid\/cit178","article-title":"Is It Time to Replace Vancomycin in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections?","volume":"56","author":"Fowler","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/599346","article-title":"Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut","volume":"49","author":"Tissing","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1542\/peds.2010-3081","article-title":"A Randomized Study of a Monoclonal Antibody (Pagibaximab) to Prevent Staphylococcal Sepsis","volume":"128","author":"Weisman","year":"2011","journal-title":"Pediatrics"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/adc.87.4.312","article-title":"Clinical and radiographic spectrum of septic pulmonary embolism","volume":"87","author":"Wong","year":"2002","journal-title":"Arch. Dis. Child."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.jpeds.2013.07.029","article-title":"Intestinal Inflammatory Biomarkers and Outcome in Pediatric Clostridium difficile Infections","volume":"163","author":"Stauber","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1093\/clinids\/18.Supplement_4.S265","article-title":"Clostridium difficile: History of Its Role as an Enteric Pathogen and the Current State of Knowledge About the Organism","volume":"18","author":"Bartlett","year":"1994","journal-title":"Clin. Infect. Dis."},{"key":"ref_106","first-page":"S63","article-title":"Clostridium difficile Infections: Emerging Epidemiology and New Treatments","volume":"2","author":"Cohen","year":"2009","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1469-0691.12418","article-title":"European Society of Clinical Microbiology and Infectious Diseases: Update of the treatment guidance document for Clostridium difficile infection","volume":"20","author":"Debast","year":"2014","journal-title":"Clin. Microbiol. Infect"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cix1085","article-title":"Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)","volume":"66","author":"McDonald","year":"2018","journal-title":"Clin Infect Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MPG.0b013e3181f97209","article-title":"Clostridium difficile Infection and Treatment in the Pediatric Inflammatory Bowel Disease Population","volume":"52","author":"Mezoff","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1086\/501126","article-title":"Management and Outcomes of a First Recurrence of Clostridium difficile-Associated Disease in Quebec, Canada","volume":"42","author":"Routhier","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1542\/peds.2009-3363","article-title":"Fecal Bacteriotherapy for Relapsing Clostridium difficile Infection in a Child: A Proposed Treatment Protocol","volume":"126","author":"Russell","year":"2010","journal-title":"Pediatrics"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1542\/peds.2012-2992","article-title":"Clostridium difficile Infection in Infants and Children","volume":"131","author":"Schutze","year":"2013","journal-title":"Pediatrics"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/cid\/ciu135","article-title":"Fecal Microbiota Transplant for Relapsing Clostridium difficile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study","volume":"58","author":"Youngster","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1097\/PCC.0b013e31828a846d","article-title":"Point Prevalence Survey of Antimicrobial Utilization in the Cardiac and Pediatric Critical Care Unit","volume":"14","author":"Blinova","year":"2013","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1542\/peds.2005-1707","article-title":"Reported Medication Use in the Neonatal Intensive Care Unit: Data From a Large National Data Set","volume":"117","author":"Clark","year":"2006","journal-title":"Pediatrics"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1086\/510393","article-title":"Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship","volume":"44","author":"Dellit","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1542\/peds.2014-2579","article-title":"Antimicrobial Stewardship Programs in Freestanding Children\u2019s Hospitals","volume":"135","author":"Hersh","year":"2014","journal-title":"Pediatrics"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1086\/513203","article-title":"The Rationale for Revising the Clinical and Laboratory Standards Institute Vancomycin Minimal Inhibitory Concentration Interpretive Criteria for Staphylococcus aureus","volume":"44","author":"Tenover","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/cid\/cir935","article-title":"The Clinical Significance of Vancomycin Minimum Inhibitory Concentration in Staphylococcus aureus Infections: A Systematic Review and Meta-analysis","volume":"54","author":"Lodise","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/INF.0b013e3181906e40","article-title":"Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate","volume":"28","author":"Frymoyer","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/jac\/dky525","article-title":"Development and external evaluation of a population pharmacokinetic model for continuous and intermittent administration of vancomycin in neonates and infants using prospectively collected data","volume":"74","author":"Germovsek","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/PRS.0b013e318219c171","article-title":"The Levels of Evidence and Their Role in Evidence-Based Medicine","volume":"128","author":"Burns","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jac\/dkr442","article-title":"Continuous versus intermittent infusion of vancomycin for the treatment of Gram-positive infections: Systematic review and meta-analysis","volume":"67","author":"Cataldo","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijantimicag.2015.10.019","article-title":"Continuous versus intermittent infusion of vancomycin in adult patients: A systematic review and meta-analysis","volume":"47","author":"Hao","year":"2016","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Costenaro, P., Minotti, C., Cuppini, E., Barbieri, E., Giaquinto, C., and Don\u00e0, D. (2020). Optimizing Antibiotic Treatment Strategies for Neonates and Children: Does Implementing Extended or Prolonged Infusion Provide any Advantage?. 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