{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:32:17Z","timestamp":1788809537109,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Over the past few decades, several publications have investigated the role of Epstein-Barr virus (EBV) in head and neck squamous cell carcinomas, and an increasing number of them have shown its presence in laryngeal tumors. The purpose of this meta-analysis was to evaluate the association of EBV with laryngeal carcinoma. The search was carried out in two databases, Scopus and PubMed, using the following terms: \u201cEpstein-Barr virus\u201d and \u201claryngeal carcinoma\u201d. A total of 187 records were found, of which 31 were selected for meeting the inclusion and exclusion criteria. The meta-analysis yielded an overall pooled prevalence of 43.72% (95% confidence interval (CI): 34.35\u201353.08). Studies carried out in Europe and Eurasia had slightly higher pooled prevalence than other subgroups, while the prevalence of studies performed in developed countries was higher than in developing countries (46.37% vs. 34.02%). Furthermore, laryngeal carcinoma occurred almost three times as often among EBV-infected individuals compared to those without EBV infection (odds ratio = 2.86 (95% CI: 1.18\u20136.90); Begg\u2019s test, p = 0.843 and Egger\u2019s test, p = 0.866). Our findings support the idea that EBV is related to laryngeal carcinoma. However, further studies are needed before recognizing a definitive etiological role of EBV in the development and\/or progression of laryngeal carcinomas.<\/jats:p>","DOI":"10.3390\/pathogens10111429","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T22:25:54Z","timestamp":1636064754000},"page":"1429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Epstein-Barr Virus-Associated Carcinoma of the Larynx: A Systematic Review with Meta-Analysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-7308","authenticated-orcid":false,"given":"Marcos Antonio Pereira","family":"de Lima","sequence":"first","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"},{"name":"Cear\u00e1 Cancer Institute, ICC, Fortaleza 60430-230, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1life Di\u00eago Lima","family":"Silva","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Carlos Silva","family":"do Nascimento Filho","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Lima","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro de Souza","family":"Bezerra","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aline Barroso","family":"Rocha","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally de Fran\u00e7a Lacerda","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Fl\u00e1vio Fontenelle","family":"Pinheiro Junior","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Socorro Vieira","family":"Gadelha","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio Gleidiston Lima","family":"da Silva","sequence":"additional","affiliation":[{"name":"School of Medicine, Federal University of Cariri, UFCA, Barbalha 63180-000, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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