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Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi\u2019s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particularly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite\u2019s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.<\/jats:p>","DOI":"10.3390\/pathogens10111493","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T02:42:28Z","timestamp":1637116948000},"page":"1493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-3669","authenticated-orcid":false,"given":"Germ\u00e1n J.","family":"Medina-Rinc\u00f3n","sequence":"first","affiliation":[{"name":"School of Medicine and Health Sciences, Universidad del Rosario, 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