{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:33:30Z","timestamp":1760236410668,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova","award":["26\/17c\/2021"],"award-info":[{"award-number":["26\/17c\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Tuberculosis (TB) is an important opportunistic infection in HIV-positive people. We are reporting a case of a 31-year-old HIV-infected patient who was hospitalized in July 2021 for dyspnea, cough with mucopurulent sputum and asthenia. He was confirmed to have Serratia liquefaciens pneumonia and acute respiratory failure. The evolution was unfavorable despite the antibiotic, pathogenic and symptomatic treatment. Because the patient had severe immunosuppression (CD4 count = 37 cell\/mm3), we used QuantiFERON-TB Gold Plus for the detection of the Mycobacterium tuberculosis infection. The antituberculosis therapy was initiated, which resulted in a significant improvement of the general condition and the patient was discharged with the recommendation to continue antiretroviral therapy, antituberculosis treatment and Trimethoprim\/Sulfamethoxazole\u2014single tablet daily for the prophylaxis of Pneumocystis pneumonia.<\/jats:p>","DOI":"10.3390\/pathogens10111523","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T21:00:50Z","timestamp":1637528450000},"page":"1523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of QuantiFERON-TB Gold Plus in Mycobacterium Tuberculosis Detection in a Severe HIV Immunocompromised Patient\u2014Case Report"],"prefix":"10.3390","volume":"10","author":[{"given":"Florentina","family":"Dumitrescu","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u0103t\u0103lina-Gabriela","family":"Pisoschi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-5689","authenticated-orcid":false,"given":"Vlad","family":"P\u0103dureanu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea Cristina","family":"Stoian","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Dragonu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucian","family":"Giubelan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,21]]},"reference":[{"key":"ref_1","unstructured":"(2021, September 03). Global Tuberculosis Report. Available online: https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports."},{"key":"ref_2","first-page":"100223","article-title":"Evaluation of the Performance of QuantiFERON\u00ae-TB Gold plus Test in Active Tuberculosis Patients","volume":"23","author":"Orman","year":"2021","journal-title":"J. Clin. Tuberc. Mycobact. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ramos, J.M., Robledano, C., Masi\u00e1, M., Belda, S., Padilla, S., Rodr\u00edguez, J.C., and Gutierrez, F. (2012). Contribution of Interferon Gamma Release Assays Testing to the Diagnosis of Latent Tuberculosis Infection in HIV-Infected Patients: A Comparison of QuantiFERON-TB Gold In Tube, T-SPOT.TB and Tuberculin Skin Test. BMC Infect. 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Lung Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1183\/09031936.00170913","article-title":"6-Year Follow-up of 522 HIV-Positive Individuals Screened for Mycobacterium Tuberculosis Infection in Denmark","volume":"44","author":"Soborg","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.diagmicrobio.2010.09.005","article-title":"Detection of Latent Tuberculosis by the Tuberculin Skin Test and a Whole-Blood Interferon-\u03b3 Release Assay, and the Development of Active Tuberculosis in HIV-Seropositive Persons","volume":"69","author":"Santin","year":"2011","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kabeer, B.S.A., Sikhamani, R., Swaminathan, S., Perumal, V., Paramasivam, P., and Raja, A. (2009). Role of Interferon Gamma Release Assay in Active TB Diagnosis among HIV Infected Individuals. 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