{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:02:20Z","timestamp":1787320940222,"version":"build-2736575974"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71764011"],"award-info":[{"award-number":["71764011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860371"],"award-info":[{"award-number":["81860371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Province Focus on Research and Development Plan","award":["20202BBGL73047"],"award-info":[{"award-number":["20202BBGL73047"]}]},{"name":"Jiangxi Province Focus on Research and Development Plan","award":["20181BBG70033"],"award-info":[{"award-number":["20181BBG70033"]}]},{"name":"Key Laboratory Plan of Jiangxi Province","award":["20192BCD40006"],"award-info":[{"award-number":["20192BCD40006"]}]},{"name":"Jiangxi Province Natural Sciences Foundation","award":["20202BABL206118"],"award-info":[{"award-number":["20202BABL206118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>China has had a long history against schistosomiasis japonica. The most serious prognosis of chronic schistosome infection is hepatic fibrosis, which develops into advanced schistosomiasis if the process is not effectively controlled. After a more than seven decades endeavor, China has gained remarkable achievements in schistosomiasis control and achieved transmission control nationwide (infection rate of schistosomes in residents and domestic animals both less than 1%) by 2015. However, new advanced schistosomiasis cases emerge annually in China, even in areas where the transmission of schistosomiasis had been interrupted. In the present study, the residents (&gt;5 years old) in a schistosomiasis endemic village were examined for schistosomiasis every year during 1995\u20132019 by the modified Kato\u2013Katz thick smear method and\/or miracidium hatching technique. Residents who were identified to have an active infection method were treated with praziquantel at a dose of 40 mg\/kg body weight. Ultrasonography was carried out to assess the liver morbidity related to schistosomiasis in 1995 and 2019, respectively. The prevalence of schistosomiasis among residents presented a downward trend annually, from 17.89% (175\/978) in 1995 to 0 (0\/475) in 2019. Among 292 residents who received ultrasound scan both in 1995 and 2019, 141 (48.29%) presented stable liver damage, while liver fibrosis was developed severely in 86 (29.45%) and reversed in 65 (22.26%) residents. Univariate and multivariate analysis showed that anti-fibrosis treatment was the protective factor against schistosomiasis hepatic fibrosis. Males, residents aged 38 and above, fishermen, and people who did not receive anti-fibrosis treatment were groups with higher risk of liver fibrosis development. Our results revealed that although the infection rate of schistosome dropped significantly in endemic areas, liver fibrosis was still developing among some residents, even though they had received deworming treatment. Liver protection\/anti-fibrosis treatment should be administered in endemic regions and regions with historically uncontrolled transmission to slow down the deterioration of hepatic fibrosis among patients in schistosomiasis endemic areas.<\/jats:p>","DOI":"10.3390\/pathogens10121532","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:22:56Z","timestamp":1638314576000},"page":"1532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Dynamics of Hepatic Fibrosis Related to Schistosomiasis and Its Risk Factors in a Cohort of China"],"prefix":"10.3390","volume":"10","author":[{"given":"Fei","family":"Hu","sequence":"first","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yuan","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-Lu","family":"Gao","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ming","family":"Lan","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Tropical Diseases, Chinese Center for Tropical Disease Research, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Dan","family":"Lin","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases, Jiangxi Province Key Laboratory of Schistosomiasis Prevention and Control, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2019, September 10). Schistosomiasis. Updated 17 April 2019. Available online: https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/schistosomiasis."},{"key":"ref_2","unstructured":"WHO (2012). A Roadmap for Implementation: Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases, World Health Organization. Available online: https:\/\/www.who.int\/neglected_diseases\/NTD_RoadMap_2012_Fullversion.pdf."},{"key":"ref_3","first-page":"1","article-title":"Remain true to our original aspiration for farewell to the God of Plague, compose the new chapter for the national schistosomiasis control programme scientifically-Commemoration of 60th anniversary of publishing Chairman Mao Zedong\u2019s two poems \u201cFarewell to the God of Plague\u201d","volume":"30","author":"Zhou","year":"2018","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_4","first-page":"605","article-title":"Progress and challenges of schistosomiasis elimination in China","volume":"30","author":"Xu","year":"2018","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_5","first-page":"551","article-title":"Endemic status of schistosomiasis in People\u2019s Republic of China in 2019","volume":"32","author":"Zhang","year":"2020","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1086\/588826","article-title":"Regulatory Role of interleukin-10 and interferon-\u03b3 in severe hepatic central and peripheral fibrosis in uumans infected with Schistosoma japonicum","volume":"198","author":"Arnaud","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_7","first-page":"477","article-title":"Survey on newly-developed advanced schistosomiasis patients in schistosomiasis transmission-interrupted areas","volume":"25","author":"Yin","year":"2013","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1590\/0037-8682-0110-2013","article-title":"Treatment and education reduce the severity of schistosomiasis periportal fibrosis","volume":"46","author":"Silva","year":"2013","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0035-9203(03)00018-X","article-title":"Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence","volume":"98","author":"Booth","year":"2004","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0001-706X(00)00117-0","article-title":"Histological assessment of tissue repair after treatment of human schistosomiasis","volume":"77","author":"Abdel","year":"2000","journal-title":"Acta Trop."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0035-9203(93)90133-B","article-title":"Schistosomiasis japonica on Jishan Island, Jiangxi Province, People\u2019s Republic of China: Persistence of hepatic fibrosis after reduction of the prevalence of infection with age","volume":"87","author":"Wiest","year":"1993","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_12","first-page":"138","article-title":"Observation on changes of liver fibrosis due to schistotoma japonicum after treatment with praziquantel","volume":"12","author":"Qiu","year":"2000","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_13","first-page":"235","article-title":"Understanding of hepatic fibrosis and acvanced schistosomiasis in the past and future","volume":"20","author":"Cai","year":"2008","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_14","first-page":"31","article-title":"Utrasonographical characters of liver and spleen of residents due to schistosoma japonicum infection and their changes in Poyang Lake region, Jiaangxi Province","volume":"22","author":"Liu","year":"2010","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_15","unstructured":"Department of Health Disease Control of Health Ministry of the People\u2019s Republic of China (2000). Schistosomiasis Control Manual, (In Chinese)."},{"key":"ref_16","first-page":"629","article-title":"Changing trends of schistosome infection and live fibrosis among residents in the Poyang Lake region","volume":"39","author":"Hu","year":"2021","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.apar.2016.02.001","article-title":"Chapter One\u2014Evolution of the National Schistosomiasis Control Programmes in The People\u2019s Republic of China","volume":"92","author":"Xu","year":"2016","journal-title":"Adv. Parasitol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.actatropica.2013.11.028","article-title":"Integrated control programmes for schistosomiasis and other helminth infections in P.R. China","volume":"141","author":"Xu","year":"2015","journal-title":"Acta Trop."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.parint.2008.04.005","article-title":"Routine Kato\u2013Katz technique underestimates the prevalence of Schistosoma japonicum: A case study in an endemic area of the People\u2019s Republic of China","volume":"57","author":"Lin","year":"2008","journal-title":"Parasitol Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.3390\/ijerph10072799","article-title":"A Bayesian approach to estimate the prevalence of Schistosomiasis japonica infection in the Hubei Province Lake regions, China","volume":"10","author":"Xin","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_21","first-page":"20","article-title":"Comparison of the miracidium hatching test and modified Kato-Katz method for detecting Schistosoma japonicum in low prevalence areas of China","volume":"45","author":"Zhu","year":"2014","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"Wilson","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhou, S., Jin, X., Chen, X.J., Zhu, J.F., Xu, Z.P., Wang, X.F., Liu, F., Hu, W., Zhou, L., and Su, C. (2015). Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis Japonica. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139133"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Duan, Y.N., Pan, J., Chen, J.L., Zhu, D.D., Wang, J.X., Sun, X.L., Chen, L.T., and Wu, L.T. (2016). Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a\/SKP2\/P27 Pathway. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0005268"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Song, L.G., Zhang, B.B., Liu, J.H., Wang, M., Ma, X.H., Wang, L.F., Wu, X.Y., Wu, Z.D., and Wang, T.P. (2019). Reversal of liver fibrosis after splenectomy in a patient with advanced schistosomiasis japonica: A case report with 4-year follow-up. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007174"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1007\/s00436-018-5972-x","article-title":"Sorafenib and praziquantel synergistically attenuate Schistosoma japonicum-induced liver fibrosis in mice","volume":"117","author":"Ma","year":"2018","journal-title":"Parasitol. Res."},{"key":"ref_27","unstructured":"National Health and Family Planning Commission, the People\u2019s Republic of China (2019, September 15). Guideline for Providing Medical Assistance to Advanced Schistosomiasis Patients, Available online: http:\/\/www.nhc.gov.cn\/wjw\/zcjd\/201304\/9f4a98c0137b42b9951a685eef87458e.shtml."},{"key":"ref_28","first-page":"591","article-title":"Endemic status of schistosomiasis in People\u2019s Republic of China in 2013","volume":"26","author":"Lei","year":"2014","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_29","first-page":"563","article-title":"Endemic status of schistosomiasis in People\u2019s Republic of China in 2014","volume":"27","author":"Lei","year":"2015","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_30","first-page":"611","article-title":"Endemic status of schistosomiasis in People\u2019s Republic of China in 2015","volume":"28","author":"Zhang","year":"2016","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_31","first-page":"669","article-title":"Endemic status of schistosomiasis in People\u2019s Republic of China in 2016","volume":"29","author":"Zhang","year":"2017","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1007\/s00436-015-4616-7","article-title":"Advanced schisto somiasis reappeared after curing seemingly being cured for over 20 years and without known history of reexposure to Schistosoma japonicum","volume":"114","author":"Hua","year":"2015","journal-title":"Parasitol. Res."},{"key":"ref_33","first-page":"93","article-title":"Survey on know ledge and attitude of schistosomiasis control among villages in susceptible zones in Pongyang Lake area","volume":"23","author":"Tang","year":"2011","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.actatropica.2005.07.016","article-title":"The role of health education and health promotion in the control of schistosomiasis: Experiences from a 12-year intervention study in the Poyang Lake area","volume":"96","author":"Hu","year":"2005","journal-title":"Acta Trop."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1574-695X.2009.00640.x","article-title":"Factors controlling the effect of praziquantel on liver fibrosis in Schistosoma mansoni-infected patients","volume":"58","author":"Rahoud","year":"2010","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.exppara.2018.01.013","article-title":"Impact of treatment with a Protein Tyrosine Kinase Inhibitor (Genistein) on acute and chronic experimental Schistosoma mansoni infection","volume":"185","author":"Sobhy","year":"2018","journal-title":"Exp. Parasitol."},{"key":"ref_37","unstructured":"National Health Commission of the People\u2019s Republic of China (2006). Diagnostic Criteria for Schistosomiasis, WS 261-2006S."},{"key":"ref_38","unstructured":"Niamey Working Group (2000). Ultrasound in Schistosomiasis: A Practical Guide to the Standardized Use of Ultrasonography for the Assessment of Schistosomiasis-Related Morbidity, World Health Organization. TDR\/STR\/SCH\/00.1."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Agbota, G., Polman, K., Wieringa, F.T., Campos-Ponce, M., Accrombessi, M., Yovo, E., Roucher, C., Ezinm\u00e8gnon, S., Marcos, J.Y., and Vachot, L. (2019). Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222864"}],"container-title":["Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/12\/1532\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:34:48Z","timestamp":1760168088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-0817\/10\/12\/1532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["pathogens10121532"],"URL":"https:\/\/doi.org\/10.3390\/pathogens10121532","relation":{},"ISSN":["2076-0817"],"issn-type":[{"value":"2076-0817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}