{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:45:38Z","timestamp":1790070338958,"version":"4.0.1"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e1 Pesquisa do Estado do Rio de Janeiro","award":["E262013302016"],"award-info":[{"award-number":["E262013302016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Dengue (DENV) and chikungunya viruses (CHIKV) cause severe neurological complications, sometimes undiagnosed. Therefore, the use of more accessible neuroinflammatory biomarkers can be advantageous considering their diagnostic and prognostic potential for aggravated clinical outcomes. In this study, we aimed to evaluate neopterin and C-X-C motif chemokine ligand 10 (CXCL-10) in cerebrospinal fluid (CSF) for the diagnosis of neuroinvasive DENV and CHIKV. We analyzed the CSF of 66 patients with neurological disorders, comprising 12 neuroinvasive DENV\/CHIKV, 20 inflammatory control (viral, bacterial, and fungal meningitis, and autoimmune disorders), and 24 noninflammatory control (cerebrovascular disease, dementia, neoplasm). There was no difference between the concentration of CSF neopterin in the neuroinvasive DENV\/CHIKV and control groups. However, there was a significant difference in the CXCL-10 level when comparing the neuroinvasive DENV\/CHIKV group and the non-inflammatory control (p &lt; 0.05). Furthermore, we found a linear correlation between neopterin and CXCL-10 CSF levels in the three groups. For the DENV\/CHIKV neuroinvasive diagnosis, the ROC curve showed the best cut-off values for CSF neopterin at 11.23 nmol\/L (sensitivity of 67% and specificity of 63%), and for CSF CXCL-10 at 156.5 pg\/mL (91.7% sensitivity and specificity). These results show that CXCL-10 in CSF represents an accurate neuroinflammatory biomarker that may contribute to neuroinvasive DENV\/CHIKV diagnosis.<\/jats:p>","DOI":"10.3390\/pathogens10121626","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T21:47:36Z","timestamp":1639604856000},"page":"1626","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neopterin and CXCL-10 in Cerebrospinal Fluid as Potential Biomarkers of Neuroinvasive Dengue and Chikungunya"],"prefix":"10.3390","volume":"10","author":[{"given":"Marzia","family":"Puccioni-Sohler","sequence":"first","affiliation":[{"name":"Post-Graduation Programme in Infectious and Parasitic Diseases, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil"},{"name":"Cerebrospinal Fluid Laboratory, Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil"},{"name":"School of Medicine and Surgery, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20271-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samya J.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Post-Graduation Programme in Infectious and Parasitic Diseases, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz C. S.","family":"Faria","sequence":"additional","affiliation":[{"name":"Cerebrospinal Fluid Laboratory, Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-4336","authenticated-orcid":false,"given":"David C. B. I.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21942-959, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-999X","authenticated-orcid":false,"given":"Mauro J.","family":"Cabral-Castro","sequence":"additional","affiliation":[{"name":"Cerebrospinal Fluid Laboratory, Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil"},{"name":"Paulo de G\u00f3es Institute of Microbiology, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"ref_1","unstructured":"Minist\u00e9rio da Sa\u00fade (2021, September 10). Dengue. 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